Swiss TPH

Abiodun OO, Gbotosho GO, Ajaiyeoba EO, Happi CT, Hofer S, Wittlin S, Sowunmi A, Brun R & Oduola AMJ (2010) Comparison of SYBR Green I-, PicoGreen-, and [H-3]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine. Parasitol Res 106, 933-939.PM:20165881

Adams M, Christen M, Plitzko I, Zimmermann S, Brun R, Kaiser M & Hamburger M (2010) Antiplasmodial lanostanes from the Ganoderma lucidum mushroom
5. J Nat Prod 73, 897-900. PM:20384295

Allmendinger A, Spavieri J, Kaiser M, Casey R, Hingley-Wilson S, Lalvani A, Guiry M, Blunden G & Tasdemir D (2010) Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae. Phytother Res 24, 1099-1103. PM:20077438

Bakunov SA, Bakunova SM, Wenzler T, Ghebru M, Werbovetz KA, Brun R & Tidwell RR (2010) Synthesis and antiprotozoal activity of cationic 1,4-Diphenyl-1H-1,2,3-triazoles. J Med Chem 53, 254-272. PM:19928900

Bonazzi S, Barbaras D, Patiny L, Scopelliti R, Schneider P, Cole ST, Kaiser M, Brun R & Gademann K (2010) Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation. Bioorg Med Chem 18, 1464-1476. PM:20133138

Booker ML, Bastos CM, Kramer ML, Barker RH, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jimenez-Diaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R & Sybertz E (2010) Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem 285, 33054-33064. PM:20702404

Bringmann G, Bischof SK, Müller S, Gulder T, Winter C, Stich A, Moll H, Kaiser M, Brun R, Dreher J & Baumann K (2010) QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. Eur J Med Chem 45, 5370-5383. PM:20850207

Brun R & Stich A (2010) Afrikanische Trypanosomiasis oder Schlafkrankheit In: Tropenmedizin in Klinik und Praxis : mit Reise- und Migrationsmedizin. 4. Aufl., Stuttgart: Thieme, 617-629.

Brun R, Blum J, Chappuis F & Burri C (2010) Human African trypanosomiasis
21. Lancet 375, 148-159. PM:19833383

Burgess SJ, Kelly JX, Shomloo S, Wittlin S, Brun R, Liebmann K & Peyton DH (2010) Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. J Med Chem 53, 6477-6489. PM:20684562

Dong Y, McCullough KJ, Wittlin S, Chollet J & Vennerstrom JL (2010) The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone. Bioorg Med Chem Lett 20, 6359-6361. PM:20943385

Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo TJ, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R & Vennerstrom JL (2010) The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). J Med Chem 53, 481-491. PM:19924861

Faist J, Seebacher W, Kaiser M, Brun R, Saf R & Weis R (2010) Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities. Eur J Med Chem 45, 179-185. PM:19879671

Faist J, Seebacher W, Kaiser M, Brun R, Saf R & Weis R (2010) Dialkylaminoalkyl derivatives of bicyclic compounds with antiplasmodial activity. Bioorg Med Chem 18, 6796-6804. PM:20709557

Farahat AA, Kumar A, Say M, Barghash AEDM, Goda FE, Eisa HM, Wenzler T, Brun R, Liu Y, Mickelson L, Wilson WD & Boykin DW (2010) Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines. Bioorg Med Chem 18, 557-566. PM:20031421

Fotie J, Kaiser M, Delfin DA, Manley J, Reid CS, Paris JM, Wenzler T, Maes L, Mahasenan KV, Li C & Werbovetz KA (2010) Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. J Med Chem 53, 966-982. PM:20047276

Gachet MS, Kunert O, Kaiser M, Brun R, Munoz RA, Bauer R & Schuhly W (2010) Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum. J Nat Prod 73, 553-556.  PM:20307077

Gachet MS, Lecaro JS, Kaiser M, Brun R, Navarrete H, Munoz RA, Bauer R & Schuhly W (2010) Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. J Ethnopharmacol 128, 184-197. PM:20064594

Ge JF, Arai C, Yang M, Bakar MA, Lu J, Ismail NSM, Wittlin S, Kaiser M, Brun R, Charman SA, Nguyen T, Morizzi J, Itoh I & Ihara M (2010) Discovery of novel benzo[a]phenoxazine SSJ-183 as a drug candidate for malaria. ACS Med Chem Lett 1, 360-364.

Gigante F, Kaiser M, Brun R & Gilbert IH (2010) Design and preparation of sterol mimetics as potential antiparasitics. Bioorg Med Chem 18, 7291-7301. PM:20846867