Publications |
2010
Dong Y, Chollet J, Vargas M, Mansour NR, Bickle Q, Alnouti Y, Huang J, Keiser J & Vennerstrom JL (2010) Praziquantel analogs with activity against juvenile Schistosoma mansoni. Bioorg Med Chem Lett 20, 2481-2484. PM:20303754
Duthaler U, Rinaldi L, Maurelli MP, Vargas M, Utzinger J, Cringoli G & Keiser J (2010) Fasciola hepatica: Comparison of the sedimentation and FLOTAC techniques for the detection and quantification of faecal egg counts in rats. Exp Parasitol 126, 161-166. PM:20434442
Duthaler U, Smith TA & Keiser J (2010) In vivo and in vitro sensitivity of Fasciola hepatica to combinations of triclabendazole and artesunate, artemether or OZ78. Antimicrob Agents Chemother 54, 4596-4604. PM:20733042
Keiser J & Utzinger J (2010) The drugs we have and the drugs we need against major helminth infections. Adv Parasitol 73, 197-230. PM:20627144
Keiser J & Vargas M (2010) Effect of artemether, artesunate, OZ78, praziquantel, and tribendimidine alone or in combination chemotherapy on the tegument of Clonorchis sinensis. Parasitol Int 59, 472-476. PM:20416396
Keiser J (2010) In vitro and in vivo trematode models for chemotherapeutic studies. Parasitology 137, 589-603. PM:19961653
Keiser J, Duthaler U & Utzinger J (2010) Update on the diagnosis and treatment of food-borne trematode infections. Curr Opin Infect Dis 23, 513-520. PM:20683264
Keiser J, Kirchhofer C, Haschke M, Huwyler J, Dong Y, Vennerstrom JL, Vanhoff K, Kaminsky R & Malikides N (2010) Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep. Vet Parasitol 173, 228-235. PM:20674178
Keiser J, N'Guessan NA, Adoubryn KD, Silué KD, Vounatsou P, Hatz C, Utzinger J & N'Goran EK (2010) Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial. Clin Infect Dis 50, 1205-1213. PM:20350194
Keiser J, Vargas M & Doenhoff MJ (2010) Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice. Am J Trop Med Hyg 82, 112-114. PM:20065004
Keiser J, Vargas M & Vennerstrom JL (2010) Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice. J Antimicrob Chemother 65, 1991-1995. PM:20576641
Keiser J, Veneziano V, Rinaldi L, Mezzino L, Duthaler U & Cringoli G (2010) Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep. Res Vet Sci 88, 107-110. PM:19501379
Kirchhofer C, Keiser J & Huwyler J (2010) Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate. J Chromatogr B Analyt Technol Biomed Life Sci 878, 2770-2774. PM:20829125
Manneck T, Braissant O, Ellis W & Keiser J (2010) Schistosoma mansoni: antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo. Exp Parasitol 127, 260-269. PM:20732321
Manneck T, Haggenmüller Y & Keiser J (2010) Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni. Parasitology 137, 85-98. PM:19814844
Rufener L, Keiser J, Kaminsky R, Mäser P & Nilsson D (2010) Phylogenomics of ligand-gated ion channels predicts monepantel effect. PLoS Pathog 6, e1001091. PM:20838602
Saric J, Li JV, Utzinger J, Wang Y, Keiser J, Dirnhofer S, Beckonert O, Sharabiani MT, Fonville JM, Nicholson JK & Holmes E (2010) Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain. Mol Syst Biol 6, 396. PM:20664642
Utzinger J, Tanner M & Keiser J (2010) ACTs for schistosomiasis: do they act? Lancet Infect Dis 10, 579-581. PM:20705514
Wang Y, Li JV, Saric J, Keiser J, Wu J, Utzinger J & Holmes E (2010) Advances in metabolic profiling of experimental nematode and trematode infections. Adv Parasitol 73, 373-404. PM:20627148
Xiao SH, Keiser J, Chen MG, Tanner M & Utzinger J (2010) Research and development of antischistosomal drugs in the People's Republic of China a 60-year review. Adv Parasitol 73, 231-295. PM:20627145
2009
Caffrey CR, Williams DL, Todd MJ, NelsonDL, Keiser J, Utzinger J (2009) Chemotherapeutic development strategies for schistosomiasis In: Antiparasitic and Antibacterial drug discovery ed. Selzer PM. Weinheim: Wiley-Blackwell, 301-321.
Erlanger TE, Weiss S, Keiser J, Utzinger J & Wiedenmayer K (2009) Past, present, and future of Japanese encephalitis. Emerg Infect Dis 15, 1-7. PM:19116041
Halferty L, O'Neill JF, Brennan GP, Keiser J & Fairweather I (2009) Electron microscopical study to assess the in vitro effects of the synthetic trioxolane OZ78 against the liver fluke, Fasciola hepatica. Parasitology 136, 1325-1337. PM:19660154
Hodel EM, Zanolari B, Mercier T, Biollaz J, Keiser J, Olliaro P, Genton B & Decosterd LA (2009) A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 877, 867-886. PM:19249251
Keiser J (2009) In vitro and in vivo trematode models for chemotherapeutic studies. Parasitology 137, 589-603. PM:19961653
Keiser J, Chollet J, Xiao SH, Mei JY, Jiao PY, Utzinger J & Tanner M (2009) Mefloquine-an aminoalcohol with promising antischistosomal properties in mice. PLoS Negl Trop Dis 3, e350. Fulltext
Keiser J, Gruyer MS, Perrottet N, Zanolari B, Mercier T & Decosterd L (2009) Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica. J Antimicrob Chemother 63, 543-549. PM:19168863
Keiser J, Odermatt P & Tesana S (2009) Dose-response relationships and tegumental surface alterations in Opisthorchis viverrini following treatment with mefloquine in vivo and in vitro. Parasitol Res 105, 261-266. PM:19308455
Keiser J, Xiao SH, Smith TA & Utzinger J (2009) Combination chemotherapy against Clonorchis sinensis: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in the rat model. Antimicrob Agents Chemother 53, 3770-3776. PM:19581454
Kim TI, Yoo WG, Li S, Hong ST, Keiser J & Hong SJ (2009) Efficacy of artesunate and artemether against Clonorchis sinensis in rabbits. Parasitol Res 106, 153-160. PM:19802632
Li JV, Holmes E, Saric J, Keiser J, Dirnhofer S, Utzinger J & Wang Y (2009) Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy. Int J Parasitol 39, 547-558. PM:19068218
Lovis L, Mak TK, Phongluxa K, Soukhathammavong P, Sayasone S, Akkhavong K, Odermatt P, Keiser J & Felger I (2009) PCR Diagnosis of Opisthorchis viverrini and Haplorchis taichui Infections in a Lao Community in an area of endemicity and comparison of diagnostic methods for parasitological field surveys. J Clin Microbiol 47, 1517-1523. PM:19279176
O'Neill JF, Johnston RC, Halferty L, Brennan GP, Keiser J & Fairweather I (2009) Adult triclabendazole-resistant Fasciola hepatica: morphological changes in the tegument and gut following in vivo treatment with artemether in the rat model. J Helminthol 83, 151-163. PM:19368748
Saric J, Li JV, Wang Y, Holmes E, Utzinger J, Keiser J (2009) Use of Echinostoma spp. in studies on chemotherapy and metabolic profiling In: The Biology of Echinostomes eds. Fried B & Toledo R. New York: Springer, 295-325.
Saric J, Li JV, Wang Y, Keiser J, Veselkov KA, Dirnhofer S, Yap IK, Nicholson JK, Holmes E & Utzinger J (2009) Panorganismal metabolic response modelling of an experimental Echinostoma caproni infection in the mouse. J Proteome Res 8, 3899-3911. PM:19489577
Tchicaya ES, Koudou BG, Keiser J, Adja AM, Cisse G, Tanner M, Tano Y & Utzinger J (2009) Effect of repeated application of microbial larvicides on malaria transmission in central Cote d'Ivoire. J Am Mosq Control Assoc 25, 382-385. PM:19852233
Tritten L, Matile H, Brun R & Wittlin S (2009) A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity. Malar J 8, 226. PM:19821995
Xiao SH, Chollet J, Utzinger J, Mei JY, Jiao PY, Keiser J & Tanner M (2009) Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice. Parasitol Res 105, 853-861. PM:19458964
Xiao SH, Keiser J, Xue J, Tanner M, Morson G & Utzinger J (2009) Effect of single-dose oral artemether and tribendimidine on the tegument of adult Clonorchis sinensis in rats. Parasitol Res 104, 533-541. PM:18975004
2008
Erlanger TE, Keiser J & Utzinger J (2008) Effect of dengue vector control interventions on entomological parameters in developing countries: a systematic review and meta-analysis. Med Vet Entomol 22, 203-221. PM:18816269
Keiser J & Morson G (2008) Fasciola hepatica: surface tegumental responses to in vitro and in vivo treatment with the experimental fasciolicide OZ78. Exp Parasitol 119, 87-93. PM:18261730
Keiser J & Morson G (2008) Fasciola hepatica: tegumental alterations in adult flukes following in vitro and in vivo administration of artesunate and artemether. Exp Parasitol 118, 228-237. PM:17888906
Keiser J & Utzinger J (2008) Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299, 1937-1948. Fulltext
Keiser J, Rinaldi L, Veneziano V, Mezzino L, Tanner M, Utzinger J & Cringoli G (2008) Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep. Parasitol Res 3, 517-522. PM:18481085
Keiser J, Thiemann K, Endriss Y & Utzinger J (2008) Strongyloides ratti: In vitro and In vivo activity of tribendimidine. PLoS Negl Trop Dis 2, e136. Fulltext
Keiser J, Utzinger J, Xiao SH, Odermatt P & Tesana S (2008) Opisthorchis viverrini: efficacy and tegumental alterations following administration of tribendimidine in vivo and in vitro. Parasitol Res 102, 771-776. PM:18172689
Saric J, Li JV, Wang Y, Keiser J, Bundy JG, Holmes E & Utzinger J (2008) Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery. PLoS Negl Trop Dis 2, e254. Fulltext
Saric J, Wang Y, Li J, Coen M, Utzinger J, Marchesi JR, Keiser J, Veselkov K, Lindon JC, Nicholson JK & Holmes E (2008) Species variation in the fecal metabolome gives insight into differential gastrointestinal function. J Proteome Res 7, 352-360. PM:18052033
Spicher M, Roethlisberger C, Lany C, Stadelmann B, Keiser J, Ortega-Mora LM, Gottstein B & Hemphill A (2008) In vitro and in vivo treatments of Echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives. Antimicrob Agents Chemother 52, 3447-3450. Fulltext
Xiao SH, Jian X, Tanner M, Yong-Nian Z, Keiser J, Utzinger J & Hui-Qiang Q (2008) Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis: acomparative in vivo study. Acta Trop 106, 54-59. PM:18308285
Xiao SH, Xue J, Tanner M, Zhang YN, Keiser J, Utzinger J, Qiang HQ & Liu XY (2008) Effect of tribendimidine, artensunate, artemether and praziquantel, administered orally at single, mutiple or combines shots, to rats infected with Clonorchis sinensis. Chin J Parasitol Parasit Dis 26, 161-166.
Xiao SH, Xue J, Tanner M, Zhang YN, Keiser J, Utzinger J, Qiang HQ & Liu XY (2008) Effect of tribendimidine, artesunate,artemether and praziquantel, administered intragastrically at single, multiple or combined doses, to rats infected with Clonorchis sinensis. Chin J Parasitol Parasit Dis 26, 321-326.
Xue J, Utzinger J, Zhang YN, Tanner M, Keiser J & Xiao SH (2008) Artemether and tribendimidine lack activity in experimental treatment of Paragonimus westermani in the dog. Parasitol Res 102, 537-540. PM:18066711
2007
Keiser J & Utzinger J (2007) Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes. Trends Parasitol 23, 555-562. PM:17950667
Keiser J & Utzinger J (2007) Advances in the discovery and development of trematocidal drugs. Expert Opin Drug Discov 2, 9-23.
Keiser J, Utzinger J, Vennerstrom JL, Dong Y, Brennan G & Fairweather I (2007) Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica. Trans R Soc Trop Med Hyg 101, 1219-1222. PM:17905370
Keiser J, Xiao SH, Dong YX, Utzinger J & Vennerstrom JL (2007) Clonorchicidal properties of the synthetic trioxolane OZ78. J Parasitol 93, 1208-1213.
Utzinger J, Xiao SH, Tanner M, Keiser J (2007) Artemisinins for schistosomiasis and beyond. Curr Opin Investig Drugs 8, 105-116. PM:17328226
Xiao SH, Keiser J, Chollet J, Utzinger J, Dong Y, Endriss Y, Vennerstrom JL & Tanner M (2007) In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species. Antimicrob Agents Chemother 51, 1440-1445. Fulltext
2006
Keiser J, Brun R, Fried B, Utzinger J (2006 Feb ) Trematocidal activity of praziquantel and artemisinin derivatives: in vitro and in vivo investigations with adult Echinostoma caproni. Antimicrob Agents Chemother 50, 803-805. dx.doi.org/10.1128/AAC.50.2.803-805.2006
Utzinger J, Keiser J (2006) Urbanization and tropical health - then and now. Ann Trop Med Parasitol 100, 517-533. dx.doi.org/10.1179/136485906X97372