Swiss TPH

Ballif M, Hii J, Marfurt J, Crameri A, Fafale A, Felger I, Beck HP & Genton B (2010) Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology. Malar J 9, 270. PM:20925934

Hodel EM, Genton B, Zanolari B, Mercier T, Duong S, Beck HP, Olliaro P, Decosterd LA & Ariey F (2010) Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure. J Infect Dis 202, 1088-1094. PM:20726764

Kalmbach Y, Rottmann M, Kombila M, Kremsner PG, Beck HP & Kun JF (2010) Differential var gene expression in children with malaria and antidromic effects on host gene expression. J Infect Dis 202, 313-317. PM:20540611

Lim P, Wongsrichanalai C, Chim P, Khim N, Kim S, Chy S, Sem R, Nhem S, Yi P, Duong S, Bouth DM, Genton B, Beck HP, Gobert JG, Rogers WO, Coppee JY, Fandeur T, Mercereau-Puijalon O, Ringwald P, Le BJ & Ariey F (2010) Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007. Antimicrob Agents Chemother 54, 2135-2142. PM:20194689

Marfurt J, Smith TA, Hastings IM, Muller I, Sie A, Oa O, Baisor M, Reeder JC, Beck HP & Genton B (2010) Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance. Malar J  9, 8. PM:20053293

Nsanzabana C, Hastings IM, Marfurt J, Muller I, Baea K, Rare L, Schapira A, Felger I, Betschart B, Smith TA, Beck HP & Genton B (2010) Quantifying the evolution and impact of antimalarial drug resistance: drug use, spread of resistance, and drug failure over a 12-year period in Papua New Guinea. J Infect Dis 201, 435-443. PM:20047502

Pachlatko E, Rusch S, Müller A, Hemphill A, Tilley L, Hanssen E & Beck HP (2010) MAHRP2, an exported protein of Plasmodium falciparum, is an essential component of Maurer's cleft tethers. Mol Microbiol 77, 1136-1152. PM:20624222

Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, Gonzalez-Paez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA & Diagana TT (2010) Spiroindolones, a potent compound class for the treatment of malaria. Science 329, 1175-1180. PM:20813948

Schoepflin S, Lin E, Kiniboro B, DaRe JT, Mehlotra RK, Zimmerman PA, Mueller I & Felger I (2010) Treatment with coartem (artemether-lumefantrine) in Papua New Guinea. Am J Trop Med Hyg 82, 529-534. PM:20348494

Beck HP, Blake D, Darde ML, Felger I, Pedraza-Diaz S, Regidor-Cerrillo J, Gomez-Bautista M, Ortega-Mora LM, Putignani L, Shiels B, Tait A & Weir W (2009) Molecular approaches to diversity of populations of apicomplexan parasites. Int J Parasitol 39, 175-189. PM:18983997

Bongfen SE, Ntsama PM, Offner S, Smith T, Felger I, Tanner M, Alonso P, Nebie I, Romero JF, Silvie O, Torgler R & Corradin G (2009) The N-terminal domain of Plasmodium falciparum circumsporozoite protein represents a target of protective immunity. Vaccine 27, 328-335. PM:18984024

Falk N, Kaestli M, Qi W, Ott M, Baea K, Cortes A & Beck HP (2009) Analysis of Plasmodium falciparum var genes expressed in children from Papua New Guinea. J Infect Dis 200, 347-356. PM:19552523

Flueck C, Frank G, Smith T, Jafarshad A, Nebie I, Sirima SB, Olugbile S, Alonso P, Tanner M, Druilhe P, Felger I & Corradin G (2009) Evaluation of two long synthetic merozoite surface protein 2 peptides as malaria vaccine candidates. Vaccine 27, 2653-2661. PM:19428875

Hodel EM, Kabanywanyi AM, Malila A, Zanolari B, Mercier T, Beck HP, Buclin T, Olliaro P, Decosterd LA & Genton B (2009) Residual antimalarials in malaria patients from Tanzania: implications on drug efficacy assessment and spread of parasite resistance. PLoS One 4, e8184. Fulltext

Hodel EM, Ley SD, Qi W, Ariey F, Genton B & Beck HP (2009) A microarray-based system for the simultaneous analysis of single nucleotide polymorphisms in human genes involved in the metabolism of anti-malarial drugs. Malar J 8, 285. Fulltext

Koepfli C, Mueller I, Marfurt J, Goroti M, Sie A, Oa O, Genton B, Beck HP & Felger I (2009) Evaluation of Plasmodium vivax genotyping markers for molecular monitoring in clinical trials. J Infect Dis 199, 1074-1080. PM:19275476

Mugasa JP, Rottman M, Qi W, Mshinda H & Beck HP (2009) Analysis of Plasmodium falciparum var Gene Repertoire Expressed in Children with Severe Malaria from Tanzania. Infect Genet Evol 9, 378.

Steenkeste N, Dillies MA, Khim N, Sismeiro O, Chy S, Lim P, Crameri A, Bouchier C, Mercereau-Puijalon O, Beck HP, Imwong M, Dondorp AM, Socheat D, Rogier C, Coppee JY & Ariey F (2009) FlexiChip package: an universal microarray with a dedicated analysis software for high-thoughput SNPs detection linked to anti-malarial drug resistance. Malar J 8, 229. PM:19828052

Abdulla S, Oberholzer R, Juma O, Kubhoja S, Machera F, Membi C, Omari S, Urassa A, Mshinda H, Jumanne A, Salim N, Shomari M, Aebi T, Schellenberg DM, Carter T, Villafana T, Demoitie MA, Dubois MC, Leach A, Lievens M, Vekemans J, Cohen J, Ballou WR & Tanner M (2008) Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants. N Engl J Med 359, 2533-2544. PM:19064623

Abdulla S, Sagara I, Borrmann S, D'Alessandro U, Gonzalez R, Hamel M, Ogutu B, Martensson A, Lyimo J, Maiga H, Sasi P, Nahum A, Bassat Q, Juma E, Otieno L, Bjorkman A, Beck HP, Andriano K, Cousin M, Lefevre G, Ubben D & Premji Z (2008) Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial. Lancet 372, 1819-1827. PM:18926569

Beck HP & Ley S (2008) Monitoring of malaria drug resistance associated SNPs in P. falciparum on microarray In: Methods in Malaria Research 5th, eds. Ljungström I, Perlmann H, Schichtherle M, Scherf A, & Wahlgen M.  Manassas: MR4/ATCC, 248-257. Fulltext

Beck HP & Tetteh K (2008) Molecular approaches to field studies of malaria. Trends Parasitol 24, 585-589. PM:18938109

Chair: Beck, HP; Rapporteur: Felger, I (2008) Methods and techniques for clinical trials on antimalarial drug efficacy: genotyping to identify parasite population: informal consultation organized by the Medicines for Malaria Venture and cosponsored by the World Health Organization: 29-31 May 2007, Amsterdam, The Netherlands, Geneva: Medicines for Malaria Venture, 45. Fulltext

Felger I & Beck HP (2008) msp2 genotyping of Plasmodium falciparum by capillary electrophoresis and GeneMapper® Program In: Methods in Malaria Research 5th, eds. Ljungström I, Perlmann H, Schichtherle M, Scherf A, & Wahlgen M.  Manassas: MR4/ATCC, 243-247. Fulltext

Felger I, Beck HP (2008) Fitness costs of resistance to antimalarial drugs. Trends in Parasitol 24, 331-3. PM:18603474

Hodel EM, Marfurt J, Mueller D, Rippert A, Borrmann S, Mueller I, Reeder JC, Sibac P, Genton B, Beck HP (2008) Lack of multiple copies of pfmdr1 gene in Papua New Guinea. Trans R Soc Trop Med Hyg 102, 1151-3. PM:18599099

Kantele A, Marti H, Felger I, Muller D & Jokiranta TS (2008) Monkey malaria in a European traveler returning from Malaysia. Emerg Infect Dis 14, 1434-1436. PM:18760013

Marfurt J, de Monbrison F, Brega S, Barbollat L, Müller I, Reeder J, Beck HP, Picot S, Genton B (2008) Molecular markers of in vivo Plasmodium vivax resistance to amodiaquine plus sulphadoxine-pyrimethamine: mutations in pvdhfr and pvmdr1. J Inf Dis 198, 409-17. PM:18582193

Marfurt J, Müller I, Sie A, Oa O, Reeder JC, Smith TA, Beck HP, Genton B (2008) The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea. Malar J 7, 61. Fulltext

Marfurt J, Monbrison FD, Brega S, Barbollat L, Muller I, Sie A, Goroti M, Reeder JC, Beck HP, Picot S & Genton B (2008) Molecular markers of in vivo Plasmodium vivax resistance to amodiaquine plus sulfadoxine-pyrimethamine: mutations in pvdhfr and pvmdr1. J Infect Dis 198, 409-417. PM:18582193

Marfurt J, Muller I, Sie A, Oa O, Reeder JC, Smith TA, Beck HP & Genton B (2008) The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea. Malar J 7, 61. Fulltext

Müller J, Ley S, Felger I, Hemphill A, Müller N (2008) Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole. J Antimicrob Chemother 62, 72-82. PM:18408240

Schoepflin S, Marfurt J, Goroti M, Baisor M, Mueller I, Felger I (2008) Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population. Malar J 7, 78. Fulltext

Spycher C, Rug M, Pachlatko E, Hanssen E, Ferguson D, Cowman AF, Tilley L, Beck HP (2008) The Maurer's cleft protein MAHRP1 is essential for trafficking of PfEMP1 to the surface of Plasmodium falciparum-infected erythrocytes. Mol Microbiol 68, 1300-14. PM:18410498

Wentzinger L, Bopp S, Tenor H, Klar J, Brun R, Beck HP & Seebeck T (2008) Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein. Int J Parasitol 38, 1625-1637. PM:18590734

Crameri A, Marfurt J, Mugittu K, Maire N, Regös A, Coppee JY, Sismeiro O, Burki R,  Huber E, Laubscher D, Puijalon O, Genton B, Felger I, Beck HP (2007) Rapid microarray-based method for monitoring of all currently known single nucleotide polymorphisms associated with parasite resistance to antimalaria drugs. J Clin Microbiol 45, 3685-3691. Fulltext

Flück C, Schoepflin S, Smith T, Genton B, Alpers MP, Beck HP, Felger I (2007 Apr 26 ) Effect of the malaria vaccine combination B on merozoite surface antigen 2 diversity. Infect Genet Evol 7, 44-51. PM:16647307

Luginbühl A, Nikolic M, Beck HP, Wahlgren M, Lutz HU (2007) Complement factor D, albumin, and immunoglobulin G anti-band 3 protein antibodies mimic serum in promoting rosetting of malaria-infected red blood cells. Infect Immun 75, 1771-1777. Fulltext

Marfurt J, Müller I, Sie A, Maku P, Goroti M, Reeder JC, Beck HP, Genton B (2007) Low Efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea. Am J Trop Med Hyg 77, 947-954. Fulltext

Michon P, Cole-Tobian JL, Dabod E, Schoepflin S, Igu J, Susapu M, Tarongka N, Zimmerman PA, Reeder JC, Beeson JG, Schofield L, King CL, Mueller I (2007) The risk of malarial infections and disease in Papua New Guinean children. Am J Trop Med Hyg 76, 997-1008. Fulltext

Mugittu K, Priotto G, Guthmann JP, Kiguli J, Adjuik M, Snounou G, Beck HP, Mshinda H, Olliaro PL & Taylor WR (2007) Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment. Trop Med Int Health 12, 219-223. PM:17300628

Villard V, Agak GW, Frank G, Jafarshad A, Servis C, Nebie I, Sirima SB, Felger I, Arevalo-Herrera M, Herrera S, Heitz F, Backer V, Druilhe P, Kajava AV, Corradin G (2007) Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif. PLoS One 2, e645. Fulltext

Falk N, Maire N, Sama W, Owusu-Agyei S, Smith T, Beck HP, Felger I (2006) Comparison of PCR-RFLP and genescan-based genotyping for analyzing infection dynamics of Plasmodium falciparum. Am J Trop Med Hyg 74, 944-950.

Kaestli M, Cockburn IA, Cortés A, Baea K, Rowe JA, Beck HP (2006) Virulence of malaria is associated with differential expression of Plasmodium faciparum var gene subgroups in a case-control study. J Infect Dis 193, 1567-1574.

Mugittu K, Genton B, Mshinda H, Beck HP (2006) Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania1. Malar J 5, 126.

Mugittu K, Priotto G, Guthman JP, Kiguli J, Adjuik M, Snounou G, Beck HP, Mshinda H, Olliaro PL, Taylor WRJ (2006) Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of Plasmodium falciparum malaria conducted in Sub-Saharan Africa: adjustment of parasitological outcomes and assessment of genotyping effectiveness. Trop Med Int Health 11, 1350-1359.

Mugittu K, Priotto G, Guthman JP, Kiguli J, Adjuik M, Snounou G, Beck HP, Mshinda H, Olliaro PL, Taylor WRJ (2006) Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of Plasmodium falciparum malaria conducted in Sub-Saharan Africa: adjustment of parasitological outcomes and assessment of genotyping effectiveness. Trop Med Int Health 11, 1350-1359. PM:16930256

Rottmann M, Lavstsen T, Mugasa JP, Kaestli M, Jensen AT, Muller D, Theander T, Beck HP (2006 Jul ) Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian children. Infect Immun 74, 3904-3911.

Sama W, Owusu-Agyei S, Felger I, Dietz K, Smith T (2006 Jan ) Age and seasonal variation in the transition rates and detectability of Plasmodium falciparum malaria. Parasitology 132, 13-21.

Silué KD, Felger I, Utzinger J, Beck HP, Smith TA, Tanner M, N'Goran EK (2006) Prévalance, diversité antigénique et multiplicité d'infections de Plasmodium falciparum en milieu scolaire au centre de la Côte d'Ivoire. Méd Trop (Mars ) 66, 149-156.

Spielmann T, Gardiner DL, Beck HP, Trenholme K R, Kemp DJ (2006) Organization of ETRAMPs and EXP-1 at the parasite–host cell interface of malaria parasites. Mol Microbiol 59, 779-794. Fulltext

Spielmann T, Gardiner DL, Beck HP, Trenholme KR, Kemp DJ (2006) Organization of ETRAMPs and EXP-1 at the parasite–host cell interface of malaria parasites. Mol Microbiol 59, 779-794. dx.doi.org/10.1111/j.1365-2958.2005.04983.x

Spycher C, Rug M, Klonis N, Ferguson DJ, Cowman AF, Beck HP, Tilley L (2006 Jun ) Genesis of and trafficking to the Maurer's clefts of Plasmodium falciparum-infected erythrocytes. Mol Cell Biol 26, 4074-4085.