Human tuberculosis (TB) remains a global health emergency, causing 10 million new cases and 1.5 million deaths every year. TB manifests as a spectrum, ranging from self-cured or asymptomatic infection to active pulmonary and extra-pulmonary disease. Until recently, the common view was that only…

In a collaboration between teams in Lesotho and Zambia, Dr Klaus Reither (Swiss Tropical and Public Health Institute, BRCCH) and Dr Kwame Shanaube (Zambart, EDCTP) will investigate the effects of community-led interventions, rapid point-of-care diagnostics and swab self-collection in mitigating the…

The COVID-19 pandemic is straining health systems globally. Public health and primary care interventions implemented by high-income countries may be unsuccessful or infeasible in low- and middle-income countries (LMIC). Effective mitigation strategies need to be adapted to the specific…

Tuberculosis (TB) has historically been the most common infectious cause of death globally, surpassed only recently (and presumably temporarily) by the ongoing Covid-19 pandemic. TB treatment is lengthy and often unsuccessful. Even if cured, most patients are left with impaired lung function and…

Background:
Tuberculosis (TB) is a poverty-related disease which particularly affects vulnerable and underserved populations. Community-based TB triage testing as an integral part of multi-disease health campaigns has the potential to offer an impactful diagnostic strategy for people living in rural…

New, rapid, non-sputum-based point-of-care (POC) diagnostic solutions to detect TB are urgently needed. This is a prospective, multicentre cohort study (Sponsor: FIND) in which the accuracy and the diagnostic yield of the FujiLAM test will be assessed using a microbiological reference standard, an…

Tuberculosis (TB) still remains a major global challenge. In 2017, there were estimated10million new cases globally. Same year 16% of people with TB has died from the disease. In the same year, 6.4 million new cases were reported, accounting for only 64% of the total estimated incidence. Due to…

Swiss TPH is consortium member in the TB-CAPT project (Close the gap, increase Access, Provide adequate Therapy), which will help improve tuberculosis (TB) diagnosis and management at the point of care. A series of clinical trials will generate evidence to inform diagnostic strategies for TB and…

The PANACEA2 Consortium is testing new drugs and treatment regimens against tuberculisis (TB) in various African countries. Our role in this consortium is to use next-generation genome seqeuncing to study the mutations causing resistance to these drugs in Mycobacterium tuberculosis isolates…