MistraL - Mitigation strategies for communities with COVID-19 transmission in Lesotho using artificial intelligence on chest x-rays and novel rapid diagnostic tests

The COVID-19 pandemic is straining health systems globally. Public health and primary care interventions implemented by high-income countries may be unsuccessful or infeasible in low- and middle-income countries (LMIC). Effective mitigation strategies need to be adapted to the specific...

Ongoing
01.06.2020 - 31.05.2022
Intervention Study
Clinical TB
Klaus Reither
VITAL - Assessment of a viral load result-driven automated Differentiated Service Delivery Model for participants taking antiretroviral therapy in Lesotho

To sustainably provide good quality care to over 16.4 million people living with HIV on antiretroviral therapy in sub-Saharan Africa, care delivery has to shift from a “one-size-fits-all” approach to differentiated service delivery models. Such models should reallocate resources from patients who...

Ongoing
31.03.2020 - 01.04.2023
Clinical Trial
Clinical Research Unit
Nadine Bachmann , Niklaus Labhardt
GIVE MOVE - Genotype-Informed Versus Empiric Management of VirEmia: A Randomised Clinical Trial

Background: HIV-1-positive children and adolescents receiving antiretroviral therapy (ART) suffer high rates of treatment failure, predominantly caused by poor adherence to therapy and/or viral drug resistance. While high-income countries routinely use genotypic resistance testing (GRT), this...

Ongoing
01.10.2019 - 30.09.2022
Clinical Trial, Intervention Study, Research project, PhD project
Clinical Research Unit
Jennifer Brown , Niklaus Labhardt
DO-REAL - Observational Assessment of the Nation-Wide Roll-Out of Dolutegravir in Lesotho (Dolutegravir in Real Life 'DO-REAL study')

Background: Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor with low side-effects and superior treatment outcomes for people living with HIV-1 when compared to other antiretroviral drugs currently in use in low-income countries. Though some cases have been described,...

Ongoing
01.01.2019 -
Observational study, PhD project, Research project
Swiss National and Science Foundation (SNSF) / Career Eccellenza
Clinical Research Unit
Jennifer Brown , Niklaus Labhardt
PEBRA trial - Peer-Educator-coordinated vs nurse-coordinated ART refill for adolescents and young adults living with HIV in Lesotho – a cluster randomized clinical trial

 

Background

Despite tremendous progress in controlling the HIV epidemic in sub-Saharan Africa, HIV-related mortality continues to increase among adolescents and young people living with HIV (AYPLHIV). Globally, sub-Saharan Africa accounts for 85% of the AYPLHIV. Overall outcomes along the HIV care...

Ongoing
01.12.2018 - 30.11.2020
Clinical Trial
International AIDS Society (IAS) / Collaborative Initiative for Paediatric HIV Education and Research (CIPHER)
Clinical Research Unit
Alain Amstutz , Niklaus Labhardt
SESOTHO trial - SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: a multicenter, open-label, randomized clinical trial

 

Background

The World Health Organization (WHO) recommends viral load (VL) measurement as the preferred monitoring strategy for HIV-infected individuals on antiretroviral therapy (ART) in resource-limited settings. The new WHO guidelines 2016 continue to define virologic failure as two consecutive...

Ongoing
01.12.2017 -
Clinical Trial, PhD project
Swiss National and Science Foundation (SNSF) / Programme r4d , Swiss National and Science Foundation (SNSF) / Career MD-PhD programme
Clinical Research Unit
Niklaus Labhardt , Alain Amstutz
VIBRA trial (GET ON project) – Effect of village-based refill of ART following home-based same-day ART initiation vs clinic-based ART refill on viral suppression among individuals living with HIV: a cluster-randomized clinical trial in rural Lesotho

The VIBRA trial is linked to another trial, the HOSENG trial, together they constitute the GET ON (GETing tOwards Ninety) research project.

     

  • The VIBRA trial (VIllage-Based Refill of ART) is a cluster-randomized clinical trial conducted in two districts in Lesotho, southern Africa. Clusters (i.e.,...

Ongoing
01.12.2017 -
Clinical Trial, PhD project
Clinical Research Unit
Niklaus Labhardt , Alain Amstutz , Tracy Glass
Improving the HIV care cascade in Lesotho: Towards 90-90-90 - A research collaboration with the Ministry of Health

 

Background

Despite enormous progress in the last decade, HIV/AIDS remains the most important cause of morbidity and mortality in most countries of Southern Africa and a central contributor to economic underdevelopment and poverty in many societies. The 2014 UNAIDS “90-90-90” targets for 2020...

Ongoing
01.02.2016 - 31.01.2019
Clinical Trial
Biostatistics Frequentist modelling
Niklaus Labhardt , Tracy Glass
Infectious and non-communicable health conditions among East African immigrants at arrival and post integration in Switzerland

Background and Rationale
East African immigrants comprise one of the most important groups among newly arriving immigrants in Switzerland. At arrival they may suffer from previously undiagnosed parasitic or viral infections as well as from mental health conditions. After arrival and eventual...

Ongoing
01.01.2016 - 31.12.2018
Research project