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2021
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McCartney D.L, Min J.L, Richmond R.C, Lu A.T, Sobczyk M.K, Davies G, Broer L, Guo X, Jeong A, Jung J, Kasela S, Katrinli S, Kuo P.L, Matias-Garcia P.R, Mishra P.P, Nygaard M, Palviainen T, Patki A, Raffield L.M, Ratliff S.M, Richardson T.G, Robinson O, Soerensen M, Sun D, Tsai P.C, van der Zee M.D, Walker R.M, Wang X, Wang Y, Xia R, Xu Z, Yao J, Zhao W, Correa A, Boerwinkle E, Dugue P.A, Durda P, Elliott H.R, Gieger C, Genetics of DNA Methylation Consortium, de Geus E.J.C, Harris S.E, Hemani G, Imboden M, Kahonen M, Kardia S.L.R, Kresovich J.K, Li S, Lunetta K.L, Mangino M, Mason D, McIntosh A.M, Mengel-From J, Moore A.Z, Murabito J.M, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ollikainen M, Pankow J.S, Pedersen N.L, Peters A, Polidoro S, Porteous D.J, Raitakari O, Rich S.S, Sandler D.P, Sillanpaa E, Smith A.K, Southey M.C, Strauch K, Tiwari H, Tanaka T, Tillin T, Uitterlinden A.G, Van Den Berg D.J, van Dongen J, Wilson J.G, Wright J, Yet I, Arnett D, Bandinelli S, Bell J.T, Binder A.M, Boomsma D.I, Chen W, Christensen K, Conneely K.N, Elliott P, Ferrucci L, Fornage M, Hagg S, Hayward C, Irvin M, Kaprio J, Lawlor D.A, Lehtimaki T, Lohoff F.W, Milani L, Milne R.L, Probst-Hensch N, Reiner A.P, Ritz B, Rotter J.I, Smith J.A, Taylor J.A, van Meurs J.B.J, Vineis P, Waldenberger M, Deary I.J, Relton C.L, Horvath S, Marioni R.E. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biol. 2021;22:194. (TOPMed). DOI: 10.1186/s13059-021-02398-9

2021
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Probst-Hensch N, Jeong A, Stolz D, Pons M, Soccal P.M, Bettschart R, Jarvis D, Holloway J.W, Kronenberg F, Imboden M, Schindler C, Lovison G.F. Causal effects of body mass index on airflow obstruction and forced mid-expiratory flow: a mendelian randomization study taking interactions and age-specific instruments into consideration toward a life course perspective. Front Public Health. 2021;9:584955. DOI: 10.3389/fpubh.2021.584955

2021
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van Nunen E, Hoek G, Tsai M.Y, Probst-Hensch N, Imboden M, Jeong A, Naccarati A, Tarallo S, Raffaele D, Nieuwenhuijsen M, Vlaanderen J, Gulliver J, Amaral A.F.S, Vineis P, Vermeulen R. Short-term personal and outdoor exposure to ultrafine and fine particulate air pollution in association with blood pressure and lung function in healthy adults. Environ Res. 2021;194:110579. DOI: 10.1016/j.envres.2020.110579

2021
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Accordini S, Calciano L, Marcon A, Pesce G, Anto J.M, Beckmeyer-Borowko A.B, Carsin A.E, Corsico A.G, Imboden M, Janson C, Keidel D, Locatelli F, Svanes C, Burney P.G.J, Jarvis D, Probst-Hensch N.M, Minelli C. Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study. Sci Rep. 2020;10:3452. DOI: 10.1038/s41598-020-60478-5

2020
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Aebi N.J, Bringolf-Isler B, Schaffner E, Caviezel S, Imboden M, Probst-Hensch N. Patterns of cross-sectional and predictive physical activity in Swiss adults aged 52+: results from the SAPALDIA cohort. Swiss Med Wkly. 2020;150:w20266. DOI: 10.4414/smw.2020.20266

2020
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Amaral A.F.S, Imboden M, Wielscher M, Rezwan F.I, Minelli C, Garcia-Aymerich J, Peralta G.P, Auvinen J, Jeong A, Schaffner E, Beckmeyer-Borowko A, Holloway J.W, Jarvelin M.R, Probst-Hensch N.M, Jarvis D.L, ALEC consortium. Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study. BMC Pulm Med. 2020;20:171. DOI: 10.1186/s12890-020-01212-9

2020
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Carsin A.E, Keidel D, Fuertes E, Imboden M, Weyler J, Nowak D, Heinrich J, Pascual Erquicia S, Martinez-Moratalla J, Huerta I, Sanchez J.L, Schaffner E, Caviezel S, Beckmeyer-Borowko A, Raherison C, Pin I, Demoly P, Leynaert B, Cerveri I, Squillacioti G, Accordini S, Gislason T, Svanes C, Toren K, Forsberg B, Janson C, Jogi R, Emtner M, Gomez Real F, Jarvis D, Guerra S, Dharmage S.C, Probst-Hensch N, Garcia-Aymerich J. Regular physical activity levels and incidence of restrictive spirometry pattern: a longitudinal analysis of two population-based cohorts. Am J Epidemiol. 2020;89(12):1521-1528. DOI: 10.1093/aje/kwaa087

2020
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Cerletti P, Eze I.C, Schaffner E, Foraster M, Vienneau D, Cajochen C, Wunderli J.M, Röösli M, Stolz D, Pons M, Imboden M, Probst-Hensch N. The independent association of source-specific transportation noise exposure, noise annoyance and noise sensitivity with health-related quality of life. Environ Int. 2020;143:105960. DOI: 10.1016/j.envint.2020.105960

2020
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Cerletti P, Keidel D, Imboden M, Schindler C, Probst-Hensch N. The modifying role of physical activity in the cross-sectional and longitudinal association of health-related quality of life with physiological functioning-based latent classes and metabolic syndrome. Health Qual Life Outcomes. 2020;18:345. DOI: 10.1186/s12955-020-01557-z

2020
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Demetz E, Tymoszuk P, Hilbe R, Volani C, Haschka D, Heim C, Auer K, Lener D, Zeiger L.B, Pfeifhofer-Obermair C, Boehm A, Obermair G.J, Ablinger C, Coassin S, Lamina C, Kager J, Petzer V, Asshoff M, Schroll A, Nairz M, Dichtl S, Seifert M, von Raffay L, Fischer C, Barros-Pinkelnig M, Brigo N, Valente de Souza L, Sopper S, Hirsch J, Graber M, Gollmann-Tepekoylu C, Holfeld J, Halper J, Macheiner S, Gostner J, Vogel G.F, Pechlaner R, Moser P, Imboden M, Marques-Vidal P, Probst-Hensch N.M, Meiselbach H, Strauch K, Peters A, Paulweber B, Willeit J, Kiechl S, Kronenberg F, Theurl I, Tancevski I, Weiss G. The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development. Eur Heart J. 2020;41(40):3949-3959. DOI: 10.1093/eurheartj/ehaa140

2020
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Eze I.C, Foraster M, Schaffner E, Vienneau D, Pieren R, Imboden M, Wunderli J.M, Cajochen C, Brink M, Röösli M, Probst-Hensch N. Incidence of depression in relation to transportation noise exposure and noise annoyance in the SAPALDIA study. Environ Int. 2020;144:106014. DOI: 10.1016/j.envint.2020.106014

2020
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Eze I.C, Jeong A, Schaffner E, Rezwan F.I, Ghantous A, Foraster M, Vienneau D, Kronenberg F, Herceg Z, Vineis P, Brink M, Wunderli J.M, Schindler C, Cajochen C, Röösli M, Holloway J.W, Imboden M, Probst-Hensch N. Genome-wide DNA methylation in peripheral blood and long-term exposure to source-specific transportation noise and air pollution: the SAPALDIA study. Environ Health Perspect. 2020;128(6):67003. DOI: 10.1289/EHP6174

2020
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Fawcett K.A, Obeidat M, Melbourne C, Shrine N, Guyatt A.L, John C, Luan J, Richmond A, Moksnes M.R, Granell R, Weiss S, Imboden M, May-Wilson S, Hysi P, Boutin T.S, Portas L, Flexeder C, Harris S.E, Wang C.A, Lyytikainen L.P, Palviainen T, Foong R.E, Keidel D, Minelli C, Langenberg C, Bosse Y, Van den Berge M, Sin D.D, Hao K, Campbell A, Porteous D, Padmanabhan S, Smith B.H, Evans D.M, Ring S, Langhammer A, Hveem K, Willer C, Ewert R, Stubbe B, Pirastu N, Klaric L, Joshi P.K, Patasova K, Massimo M, Polasek O, Starr J.M, Karrasch S, Strauch K, Meitinger T, Rudan I, Rantanen T, Pietilainen K, Kahonen M, Raitakari O.T, Hall G.L, Sly P.D, Pennell C.E, Kaprio J, Lehtimaki T, Vitart V, Deary I.J, Jarvis D, Wilson J.F, Spector T, Probst-Hensch N, Wareham N.J, Volzke H, Henderson J, Strachan D.P, Brumpton B.M, Hayward C, Hall I.P, Tobin M.D, Wain L.V. Variants associated with HHIP expression have sex-differential effects on lung function. Wellcome Open Res. 2020;5:111. DOI: 10.12688/wellcomeopenres.15846.1

2020
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Hoang T.T, Sikdar S, Xu C.J, Lee M.K, Cardwell J, Forno E, Imboden M, Jeong A, Madore A.M, Qi C, Wang T, Bennett B.D, Ward J.M, Parks C.G, Beane-Freeman L.E, King D, Motsinger-Reif A, Umbach D.M, Wyss A.B, Schwartz D.A, Celedon J.C, Laprise C, Ober C, Probst-Hensch N, Yang I.V, Koppelman G.H, London S.J. Epigenome-wide association study of DNA methylation and adult asthma in the agricultural lung health study. Eur Respir J. 2020;56(3). DOI: 10.1183/13993003.00217-2020

2020
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Mancini F.R, Laine J.E, Tarallo S, Vlaanderen J, Vermeulen R, van Nunen E, Hoek G, Probst-Hensch N, Imboden M, Jeong A, Gulliver J, Chadeau-Hyam M, Nieuwenhuijsen M, de Kok T.M, Piepers J, Krauskopf J, Kleinjans J.C.S, Vineis P, Naccarati A. microRNA expression profiles and personal monitoring of exposure to particulate matter. Environ Pollut. 2020;263(Pt B):114392. DOI: 10.1016/j.envpol.2020.114392

2020
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Rezwan F.I, Imboden M, Amaral A.F.S, Wielscher M, Jeong A, Triebner K, Real F.G, Jarvelin M.R, Jarvis D, Probst-Hensch N.M, Holloway J.W. Association of adult lung function with accelerated biological aging. Aging. 2020;12(1):518-542. DOI: 10.18632/aging.102639

2020
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Schmidt J.C, Vogt S, Imboden M, Schaffner E, Grize L, Zemp E, Probst-Hensch N, Zitzmann N.U. Dental and periodontal health in a Swiss population-based sample of older adults: a cross-sectional study. Eur J Oral Sci. 2020;128:508-517. DOI: 10.1111/eos.12738

2020
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van Nunen E, Vermeulen R, Tsai M.Y, Probst-Hensch N, Ineichen A, Imboden M, Naccarati A, Tarallo S, Raffaele D, Ranzi A, Nieuwenhuijsen M, Jarvis D, Amaral A.F, Vlaanderen J, Meliefste K, Brunekreef B, Vineis P, Gulliver J, Hoek G. Associations between modeled residential outdoor and measured personal exposure to ultrafine particles in four European study areas. Atmos Environ. 2020;226:117353. DOI: 10.1016/j.atmosenv.2020.117353

2020
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West E.A, Anker D, Amati R, Richard A, Wisniak A, Butty A, Albanese E, Bochud M, Chiolero A, Crivelli L, Cullati S, d'Acremont V, Epure A.M, Fehr J, Flahault A, Fornerod L, Frank I, Frei A, Michel G, Gonseth S, Guessous I, Imboden M, Kahlert C.R, Kaufmann L, Kohler P, Mösli N, Paris D, Probst-Hensch N, Rodondi N, Stringhini S, Vermes T, Vollrath F, Puhan M.A, Corona Immunitas Research Group. Corona immunitas: study protocol of a nationwide program of SARS-CoV-2 seroprevalence and seroepidemiologic studies in Switzerland. Int J Public Health. 2020;65:1529–1548. DOI: 10.1007/s00038-020-01494-0

2020
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Carsin A.E, Fuertes E, Schaffner E, Jarvis D, Antó J.M, Heinrich J, Bellisario V, Svanes C, Keidel D, Imboden M, Weyler J, Nowak D, Martinez-Moratalla J, Gullón J.A, Sanchez Ramos J.L, Caviezel S, Beckmeyer-Borowko A, Raherison C, Pin I, Demoly P, Cerveri I, Accordini S, Gislason T, Toren K, Forsberg B, Janson C, Jogi R, Emtner M, Gómez Real F, Raza W, Leynaert B, Pascual S, Guerra S, Dharmage S.C, Probst-Hensch N, Garcia-Aymerich J. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. Respir Med. 2019;146:116-123. DOI: 10.1016/j.rmed.2018.11.017

2019
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Eze I.C, Essé C, Bassa F.K, Koné S, Acka F, Schindler C, Imboden M, Laubhouet-Koffi V, Kouassi D, N'Goran E.K, Utzinger J, Bonfoh B, Probst-Hensch N. Asymptomatic Plasmodium infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire. Diabetes Res Clin Pract. 2019;156:107845. DOI: 10.1016/j.diabres.2019.107845

2019
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Imboden M, Wielscher M, Rezwan F.I, Amaral A.F.S, Schaffner E, Jeong A, Beckmeyer-Borowko A, Harris S.E, Starr J.M, Deary I.J, Flexeder C, Waldenberger M, Peters A, Schulz H, Chen S, Sunny S.K, Karmaus W.J.J, Jiang Y, Erhart G, Kronenberg F, Arathimos R, Sharp G.C, Henderson A.J, Fu Y, Piirilä P, Pietiläinen K.H, Ollikainen M, Johansson A, Gyllensten U, de Vries M, van der Plaat D.A, de Jong K, Boezen H.M, Hall I.P, Tobin M.D, Jarvelin M.R, Holloway J.W, Jarvis D, Probst-Hensch N.M. Epigenome-wide association study of lung function level and its change. Eur Respir J. 2019;54:1900457. DOI: 10.1183/13993003.00457-2019

2019
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Jeong A, Imboden M, Ghantous A, Novoloaca A, Carsin A.E, Kogevinas M, Schindler C, Lovison G, Herceg Z, Cuenin C, Vermeulen R, Jarvis D, Amaral A.F.S, Kronenberg F, Vineis P, Probst-Hensch N. DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma. Int J Environ Res Public Health. 2019;16(4):600. DOI: 10.3390/ijerph16040600

2019
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Meier-Girard D, Delgado-Eckert E, Schaffner E, Schindler C, Künzli N, Adam M, Pichot V, Kronenberg F, Imboden M, Frey U, Probst-Hensch N. Association of long-term exposure to traffic-related PM10 with heart rate variability and heart rate dynamics in healthy subjects. Environ Int. 2019;125:107-116. DOI: 10.1016/j.envint.2019.01.031

2019
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Mostafavi N, Jeong A, Vlaanderen J, Imboden M, Vineis P, Jarvis D, Kogevinas M, Probst-Hensch N, Vermeulen R. The mediating effect of immune markers on the association between ambient air pollution and adult-onset asthma. Sci Rep. 2019;9:8818. DOI: 10.1038/s41598-019-45327-4

2019
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Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve N.F, Guyatt A.L, Jackson V.E, Shrine N, Qiao D, Bartz T.M, Kim D.K, Lee M.K, Latourelle J.C, Li X, Morrow J.D, Obeidat M, Wyss A.B, Bakke P, Barr R.G, Beaty T.H, Belinsky S.A, Brusselle G.G, Crapo J.D, de Jong K, DeMeo D.L, Fingerlin T.E, Gharib S.A, Gulsvik A, Hall I.P, Hokanson J.E, Kim W.J, Lomas D.A, London S.J, Meyers D.A, O'Connor G.T, Rennard S.I, Schwartz D.A, Sliwinski P, Sparrow D, Strachan D.P, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk J.M, Yim J.J, Zhou X, Bosse Y, Manichaikul A, Lahousse L, Silverman E.K, Boezen H.M, Wain L.V, Tobin M.D, Hobbs B.D, Cho M.H, SpiroMeta Consortium, International COPD Genetics Consortium. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019;51(3):494-505. DOI: 10.1038/s41588-018-0342-2

2019
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Shrine N, Guyatt A.L, Erzurumluoglu A.M, Jackson V.E, Hobbs B.D, Melbourne C.A, Batini C, Fawcett K.A, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve N.F, Obeidat M, Zhao J.H, Wielscher M, Understanding Society Scientific Group, Weiss S, Kentistou K.A, Cook J.P, Sun B.B, Zhou J, Hui J, Karrasch S, Imboden M, Harris S.E, Marten J, Enroth S, Kerr S.M, Surakka I, Vitart V, Lehtimäki T, Allen R.J, Bakke P.S, Beaty T.H, Bleecker E.R, Bossé Y, Brandsma C.A, Chen Z, Crapo J.D, Danesh J, DeMeo D.L, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell A.L, Hao K, Hoffman J.D, Hokanson J.E, Homuth G, Joshi P.K, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville J.C, Murray A, Nickle D.C, Packer R, Parker M.M, Paynton M.L, Porteous D.J, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin D.D, Smith B.H, Soler Artigas M, Sparrow D, Tal-Singer R, Timmers Prhj, Van den Berge M, Whittaker J.C, Woodruff P.G, Yerges-Armstrong L.M, Troyanskaya O.G, Raitakari O.T, Kähönen M, Polašek O, Gyllensten U, Rudan I, Deary I.J, Probst-Hensch N.M, Schulz H, James A.L, Wilson J.F, Stubbe B, Zeggini E, Jarvelin M.R, Wareham N, Silverman E.K, Hayward C, Morris A.P, Butterworth A.S, Scott R.A, Walters R.G, Meyers D.A, Cho M.H, Strachan D.P, Hall I.P, Tobin M.D, Wain L.V. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019;51(3):481-493. DOI: 10.1038/s41588-018-0321-7

2019
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Shrine N, Guyatt A.L, Erzurumluoglu A.M, Jackson V.E, Hobbs B.D, Melbourne C.A, Batini C, Fawcett K.A, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve N.F, Obeidat M, Zhao J.H, Wielscher M, Understanding Society Scientific Group, Weiss S, Kentistou K.A, Cook J.P, Sun B.B, Zhou J, Hui J, Karrasch S, Imboden M, Harris S.E, Marten J, Enroth S, Kerr S.M, Surakka I, Vitart V, Lehtimaki T, Allen R.J, Bakke P.S, Beaty T.H, Bleecker E.R, Bosse Y, Brandsma C.A, Chen Z, Crapo J.D, Danesh J, DeMeo D.L, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell A.L, Hao K, Hoffman J.D, Hokanson J.E, Homuth G, Joshi P.K, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville J.C, Murray A, Nickle D.C, Packer R, Parker M.M, Paynton M.L, Porteous D.J, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin D.D, Smith B.H, Artigas M.S, Sparrow D, Tal-Singer R, Timmers Prhj, Van den Berge M, Whittaker J.C, Woodruff P.G, Yerges-Armstrong L.M, Troyanskaya O.G, Raitakari O.T, Kahonen M, Polasek O, Gyllensten U, Rudan I, Deary I.J, Probst-Hensch N.M, Schulz H, James A.L, Wilson J.F, Stubbe B, Zeggini E, Jarvelin M.R, Wareham N, Silverman E.K, Hayward C, Morris A.P, Butterworth A.S, Scott R.A, Walters R.G, Meyers D.A, Cho M.H, Strachan D.P, Hall I.P, Tobin M.D, Wain L.V. Author correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019;51:1067-1068. DOI: 10.1038/s41588-019-0438-3

2019
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Accordini S, Calciano L, Marcon A, Pesce G, Anto J, Beckmeyer-Borowko A, Corsico A, Imboden M, Janson C, Keidel D, Locatelli F, Svanes C, Jarvis D, Probst-Hensch N, Minelli C. Incidence of airflow obstruction over 20 years in Europe. Eur Respir J, 2018;52(Suppl. 62):PA2267. DOI: 10.1183/13993003.congress-2018.PA2267

2018
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Amaral A.F.S, Imboden M, Wielscher M, Rezwan F.I, Minelli C, Garcia-Aymerich J, Peralta G.P, Auvinen J, Jeong A, Schaffner E, Beckmeyer-Borowko A, Holloway J.W, Jarvelin M.R, Probst-Hensch N, Jarvis D.L. Body mass index and lung function: a two-step epigenetic Mendelian randomization study. Eur Respir J, 2018;52(Suppl. 62):PA1276. DOI: 10.1183/13993003.congress-2018.PA1276

2018
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Beckmeyer-Borowko A, Imboden M, Rezwan F.I, Wielscher M, Amaral A.F.S, Jeong A, Schaffner E, Auvinen J, Sebert S, Karhunen V, Bettschart R, Turk A, Pons M, Stolz D, Kronenberg F, Arathimos R, Sharp G.C, Relton C, Henderson A.J, Jarvelin M.R, Jarvis D, Holloway J.W, Probst-Hensch N.M. SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts. Respir Res. 2018;19(1):156. DOI: 10.1186/s12931-018-0850-8

2018
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Carsin A.E, Keidel D, Fuertes E, Imboden M, Weyler J, Nowak D, Heinrich J, Urrutia I, Martinez-Moratalla J, Caviezel S, Beckmeyer-Borowko A, Raherison C, Pin I, Demoly P, Leynaert B, Cerveri I, Bono R, Accordini S, Amaral A, Gislason T, Svanes C, Toren K, Forsberg B, Janson C, Dharmage S, Jogi R, Anto J, Probst-Hensch N, Garcia-Aymerich J. Physical activity and incidence of restrictive spirometry pattern in adults. Eur Respir J, 2018;52(Suppl. 62):PA5289. DOI: 10.1183/13993003.congress-2018.PA5289

2018
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Curjuric I, Imboden M, Bettschart R, Caviezel S, Dratva J, Pons M, Rothe T, Schmidt-Trucksäss A, Stolz D, Thun G.A, Eckardstein A.V, Kronenberg F, Ferrarotti I, Probst-Hensch N.M. Alpha-1 antitrypsin deficiency: from the lung to the heart?. Atherosclerosis. 2018;270:166-172. DOI: 10.1016/j.atherosclerosis.2018.01.042

2018
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