Cretton S, Kaiser M, Karimou S, Ebrahimi S.N, Maser P, Cuendet M, Christen P. Pyridine-4(1H)-one alkaloids from Waltheria indica as antitrypanosomatid agents. J Nat Prod. 2020(in press). DOI: 10.1021/acs.jnatprod.0c00671

2020
Journal Article
PubMed (33095014)

Dawidowski M, Kalel V.C, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko I.V, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz G.M. Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity. J Med Chem. 2020;63(2):847-879. DOI: 10.1021/acs.jmedchem.9b01876

2020
Journal Article
PubMed (31860309)

Dickie E.A, Giordani F, Gould M.K, Mäser P, Burri C, Mottram J.C, Rao S.P.S, Barrett M.P. New drugs for human african trypanosomiasis: a twenty first century success story. Trop Med Infect Dis. 2020;5:29. DOI: 10.3390/tropicalmed5010029

2020
Journal Article
PubMed (32092897)
Link

Fesser A.F, Braissant O, Olmo F, Kelly J.M, Mäser P, Kaiser M. Non-invasive monitoring of drug action: a new live in vitro assay design for Chagas' disease drug discovery. PLoS Negl Trop Dis. 2020;14(7):e0008487. DOI: 10.1371/journal.pntd.0008487

2020
Journal Article
PubMed (32716934)
Link

Hoffelner M, Hassan U, Seebacher W, Dolensky J, Hochegger P, Kaiser M, Mäser P, Saf R, Weis R. New 2‑aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities. Monatsh Chem. 2020;151:1375–1385

2020
Journal Article
Link

Kaiser M, Mäser P. In vitro drug efficacy testing against Trypanosoma brucei. In: Michels P.A.M,Ginger M.L,Zilberstein D, eds. Trypanosomatids: methods and protocols. 2116, 781-789. New York: Springer, 2020. DOI: 10.1007/978-1-0716-0294-2_46

2020
Book Section
PubMed (32221955)

Mahmoud A.B, Danton O, Kaiser M, Han S, Moreno A, Abd Algaffar S, Khalid S, Oh W.K, Hamburger M, Mäser P. Lignans, amides, and saponins from Haplophyllum tuberculatum and their antiprotozoal activity. Molecules. 2020;25(12):2825. DOI: 10.3390/molecules25122825

2020
Journal Article
PubMed (32575379)
Link

Mahmoud A.B, Danton O, Kaiser M, Khalid S, Hamburger M, Mäser P. HPLC-based activity profiling for antiprotozoal compounds in Croton gratissimus and Cuscuta hyalina. Front Pharmacol. 2020;11:1246. DOI: 10.3389/fphar.2020.01246

2020
Journal Article
PubMed (32922290)
Link

Mahmoud A.B, Mäser P, Kaiser M, Hamburger M, Khalid S. Mining sudanese medicinal plants for antiprotozoal agents. Front Pharmacol. 2020;11:865. DOI: 10.3389/fphar.2020.00865

2020
Journal Article
PubMed (32581814)
Link

Petritsch M, Seebacher W, Mohsin N.U, Dolensky J, Hochegger P, Kaiser M, Maser P, Belaj F, Saf R, Kretschmer N, Alajlani M, Brantner A, Bauer R, Schuhly W, Weis R. Preparation of new 1,3-dibenzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. Eur J Med Chem. 2020(in press). DOI: 10.1016/j.ejmech.2020.112969

2020
Journal Article
PubMed (33148495)

Rao S.P.S, Lakshminarayana S.B, Jiricek J, Kaiser M, Ritchie R, Myburgh E, Supek F, Tuntland T, Nagle A, Molteni V, Maser P, Mottram J.C, Barrett M.P, Diagana T.T. Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of african trypanosomiasis. Trop Med Infect Dis. 2020;5:28. DOI: 10.3390/tropicalmed5010028

2020
Journal Article
PubMed (32079320)
Link

Vahekeni N, Neto P.M, Kayimbo M.K, Mäser P, Theophile J, da Costa E, Falquet J, van Eeuwijk P. Use of herbal remedies in the management of sleeping sickness in four northern provinces of Angola. J Ethnopharmacol. 2020;256:112382. DOI: 10.1016/j.jep.2019.112382

2020
Journal Article
PubMed (31743767)

Wiedemar N, Hauser D.A, Mäser P. One hundred years of Suramin. Antimicrob Agents Chemother. 2020;64(3):e01168-19. DOI: 10.1128/AAC.01168-19

2020
Journal Article
PubMed (31844000)

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig J.A, Pisco J.P, Peet C, Dranow D.M, Robinson D.A, Jansen C, Norcross N.R, Vinayak S, Anderson M, Brooks C.F, Cooper C.A, Damerow S, Delves M, Dowers K, Duffy J, Edwards T.E, Hallyburton I, Horst B.G, Hulverson M.A, Ferguson L, Jiménez-Díaz M.B, Jumani R.S, Lorimer D.D, Love M.S, Maher S, Matthews H, McNamara C.W, Miller P, O'Neill S, Ojo K.K, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz L.M, Scullion P, Sharma A, Shepherd S.M, Shishikura Y, Simeons F.R.C, Stebbins E.E, Stojanovski L, Straschil U, Tamaki F.K, Tamjar J, Torrie L.S, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo F.J, Mäser P, Kyle D.E, Winzeler E.A, Myler P.J, Wyatt P.G, Floyd D, Matthews D, Sharma A, Striepen B, Huston C.D, Gray D.W, Fairlamb A.H, Pisliakov A.V, Walpole C, Read K.D, Van Voorhis W.C, Gilbert I.H. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc Natl Acad Sci USA. 2019;116(14):7015-7020. DOI: 10.1073/pnas.1814685116

2019
Journal Article
PubMed (30894487)
Link

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker. Med Chem. 2019;15(4):409-416. DOI: 10.2174/1573406414666181015115101

2019
Journal Article
PubMed (30324885)

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. Bioorg Med Chem. 2019;27(10):2052-2065. DOI: 10.1016/j.bmc.2019.03.061

2019
Journal Article
PubMed (30962114)

Hoffelner M, Petritsch M, Ahmad S, Seebacher W, Dolensky J, Hochegger P, Kaiser M, Mäser P, Saf R, Weis R. New derivatives of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Monatsh Chem. 2019;150(11):1959-1972. DOI: 10.1007/s00706-019-02509-0

2019
Journal Article

Jourdan J, Walz A, Matile H, Schmidt A, Wu J, Wang X, Dong Y, Vennerstrom J.L, Schmidt R.S, Wittlin S, Mäser P. Stochastic protein alkylation by antimalarial peroxides. ACS Infect Dis. 2019;5(12):2067-2075. DOI: 10.1021/acsinfecdis.9b00264

2019
Journal Article
PubMed (31626733)

Mäser P. Parasiten machen Geschichte. In: Bregy C,Buschle M,Settelen-Trees D, eds. Gespräche im Garten: Kultur - Natur - Gutes Leben: , 127-131. Basel: Christoph Merian Verlag, 2019

2019
Book Section

Mohsin N.U.A, Seebacher W, Hochegger P, Faist J, Saf R, Kaiser M, Mäser P, Weis R. Synthesis of new 1-benzyl tetrahydropyridin-4-ylidene piperidinium salts and their antiplasmodial and antitrypanosomal activities. Med Chem Res. 2019;28(5):742-753. DOI: 10.1007/s00044-019-02331-7

2019
Journal Article

Rao S.P.S, Barrett M.P, Dranoff G, Faraday C.J, Gimpelewicz C.R, Hailu A, Jones C.L, Kelly J.M, Lazdins-Helds J.K, Mäser P, Mengel J, Mottram J.C, Mowbray C.E, Sacks D.L, Scott P, Spath G.F, Tarleton R.L, Spector J.M, Diagana T.T. Drug discovery for kinetoplastid diseases: future directions. ACS Infect Dis. 2019;5(2):152-157. DOI: 10.1021/acsinfecdis.8b00298

2019
Journal Article
PubMed (30543391)

Saccoliti F, Madia V.N, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet Alvarez C.M, Jennings G.K, Podust L.M, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista M.R, Summa V, Costi R, Di Santo R. Design, synthesis, and biological evaluation of new 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives as antiprotozoal agents. J Med Chem. 2019;62(3):1330-1347. DOI: 10.1021/acs.jmedchem.8b01464

2019
Journal Article
PubMed (30615444)

Walz A, Leroy D, Andenmatten N, Mäser P, Wittlin S. Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay. Malar J. 2019;18:427. DOI: 10.1186/s12936-019-3056-8

2019
Journal Article
PubMed (31849323)
Link

Wiedemar N, Zwyer M, Zoltner M, Cal M, Field M.C, Mäser P. Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei. FASEB Bioadv. 2019;1(10):595-608. DOI: 10.1096/fba.2019-00033

2019
Journal Article
PubMed (32123811)
Link

Grogg M, Hilvert D, Ebert M.O, Beck A.K, Seebach D, Kurth F, Dittrich P.S, Sparr C, Wittlin S, Rottmann M, Mäser P. Cell penetration, herbicidal activity, and in-vivo-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived from the biopolymer cyanophycin. Helvetica Chimica Acta. 2018;101(10):e1800112. DOI: 10.1002/hlca.201800112

2018
Journal Article
PubMed (30905972)

Gysin M, Braissant O, Gillingwater K, Brun R, Mäser P, Wenzler T. Isothermal microcalorimetry – a quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time. Int J Parasitol Drugs Drug Resist. 2018;8(2):159-164. DOI: 10.1016/j.ijpddr.2018.03.003

2018
Journal Article
PubMed (29587237)
Link

Kalel V.C, Mäser P, Sattler M, Erdmann R, Popowicz G.M. Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development. Curr Opin Microbiol. 2018;46:116-122. DOI: 10.1016/j.mib.2018.11.003

2018
Journal Article
PubMed (30481613)

Mäser P. Host-Microbe Interactions: Parasitology Vol 46. Curr Opin Microbiol. 2018;46:vi-viii. DOI: 10.1016/j.mib.2018.11.008

2018
Journal Item
PubMed (30553295)

Mohsin N.U.A, Seebacher W, Faist J, Hochegger P, Kaiser M, Mäser P, Belaj F, Saf R, Kretschmer N, Alajlani M, Turek I, Brantner A, Bauer R, Bucar F, Weis R. Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. Eur J Med Chem. 2018;143:97-106. DOI: 10.1016/j.ejmech.2017.11.025

2018
Journal Article
PubMed (29172086)

Mohsin N.U.A, Seebacher W, Faist J, Hochegger P, Kaiser M, Mäser P, Saf R, Weis R. The antiplasmodial and antitrypanosomal activities of novel piperazine derivatives of 3-azabicyclo[3.2.2]nonanes. Monatsh Chem. 2018;149(1):99-109. DOI: 10.1007/s00706-017-2109-3

2018
Journal Article

Mohsin N.U.A, Seebacher W, Faist J, Kretschmer N, Bauer R, Saf R, Kaiser M, Mäser P, Weis R. Modifications on tetrahydropyridin-4-ylidene ammonium salts and their antiprotozoal activities. Monatsh Chem. 2018;149(4):801-812. DOI: 10.1007/s00706-017-2111-9

2018
Journal Article

Oufir M, Gillingwater K, Hamburger M, Roditi I, Brun R, Mäser P, Wenzler T. Pharmacokinetic profiles reconcile in vitro and in vivo activities of novel trypanocidal compounds. Matters. 2018;Aug 14th:07000009. DOI: 10.19185/matters.201807000009

2018
Journal Article
Link

Saccoliti F, Madia V.N, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P. Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents. Eur J Med Chem. 2018;156:53-60. DOI: 10.1016/j.ejmech.2018.06.063

2018
Journal Article
PubMed (30006174)

Schmidt R.S, Macedo J.P, Steinmann M.E, Salgado A.G, Butikofer P, Sigel E, Rentsch D, Mäser P. Transporters of Trypanosoma brucei: phylogeny, physiology, pharmacology. FEBS J. 2018;285(6):1012-1023. DOI: 10.1111/febs.14302

2018
Journal Article
PubMed (29063677)

Subramaniam S, Schmid C.D, Guan X.L, Mäser P. Using yeast synthetic lethality to inform drug combination for malaria. Antimicrob Agents Chemother. 2018;62(4):e01533-17. DOI: 10.1128/AAC.01533-17

2018
Journal Article
PubMed (29358287)
Link

Wiedemar N, Graf F.E, Zwyer M, Ndomba E, Kunz Renggli C, Cal M, Schmidt R.S, Wenzler T, Mäser P. Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei. Mol Microbiol. 2018;107(1):57-67. DOI: 10.1111/mmi.13854

2018
Journal Article
PubMed (28963732)
Link

Baumgärtner F, Jourdan J, Scheurer C, Blasco B, Campo B, Mäser P, Wittlin S. In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate. Malar J. 2017;16:45. DOI: 10.1186/s12936-017-1696-0

2017
Journal Article
PubMed (28122617)
Link

Dawidowski M, Emmanouilidis L, Kalel V.C, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz G.M. Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science. 2017;355(6332):1416-1420. DOI: 10.1126/science.aal1807

2017
Journal Article
PubMed (28360328)

Faist J, Hinteregger C, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. New derivatives of 7-chloroquinolin-4-amine with antiprotozoal activity. Bioorg Med Chem. 2017;25(3):941-948. DOI: 10.1016/j.bmc.2016.12.006

2017
Journal Article
PubMed (28031151)

Guan X.L, Mäser P. Comparative sphingolipidomics of disease-causing trypanosomatids reveal unique lifecycle- and taxonomy-specific lipid chemistries. Sci Rep. 2017;7:13617. DOI: 10.1038/s41598-017-13931-x

2017
Journal Article
PubMed (29051559)
Link