Barda B, Schindler C, Wampfler R, Ame S, Ali S.M, Keiser J. Comparison of real-time PCR and the Kato-Katz method for the diagnosis of soil-transmitted helminthiasis and assessment of cure in a randomized controlled trial. BMC Microbiol. 2020;20:298. DOI: 10.1186/s12866-020-01963-9

2020
Journal Article
PubMed (33008301)
Link

Buchter V, Ong Y.C, Mouvet F, Ladaycia A, Lepeltier E, Rothlisberger U, Keiser J, Gasser G. Multidisciplinary preclinical investigations on three oxamniquine analogues as novel drug candidates for schistosomiasis. Chemistry. 2020(in press). DOI: 10.1002/chem.202002856

2020
Journal Article
PubMed (32852116)

Buchter V, Priotti J, Leonardi D, Lamas M.C, Keiser J. Activity of novel oral formulations of albendazole and mebendazole against Heligmosomoides polygyrus in vitro and in vivo. J Pharm Sci. 2020;109(5):1819-1826. DOI: 10.1016/j.xphs.2020.02.002

2020
Journal Article
PubMed (32070702)

Buchter V, Priotti J, Leonardi D, Lamas M.C, Keiser J. Preparation, physicochemical characterization and In vitro and In vivo activity against Heligmosomoides polygyrus of novel oral formulations of albendazole and mebendazole. J Pharm Sci. 2020;109(5):1819-1826. DOI: 10.1016/j.xphs.2020.02.002

2020
Journal Article
PubMed (32070702)

De Rycker M, Horn D, Aldridge B, Amewu R.K, Barry C.E, Buckner F.S, Cook S, Ferguson M.A.J, Gobeau N, Herrmann J, Herrling P, Hope W, Keiser J, Lafuente-Monasterio M.J, Leeson P.D, Leroy D, Manjunatha U.H, McCarthy J, Miles T.J, Mizrahi V, Moshynets O, Niles J, Overington J.P, Pottage J, Rao S.P.S, Read K.D, Ribeiro I, Silver L.L, Southern J, Spangenberg T, Sundar S, Taylor C, Van Voorhis W, White N.J, Wyllie S, Wyatt P.G, Gilbert I.H. Setting our sights on infectious diseases. ACS Infect Dis. 2020;6(1):3-13. DOI: 10.1021/acsinfecdis.9b00371

2020
Journal Article
PubMed (31808676)
Link

Else K.J, Keiser J, Holland C.V, Grencis R.K, Sattelle D.B, Fujiwara R.T, Bueno L.L, Asaolu S.O, Sowemimo O.A, Cooper P.J. Whipworm and roundworm infections. Nat Rev Dis Primers. 2020;6(1):44. DOI: 10.1038/s41572-020-0171-3

2020
Journal Article
PubMed (32467581)

Keiser J, Koch V, Deckers A, Cheung H.T.A, Jung N, Brase S. Naturally occurring cardenolides affecting Schistosoma mansoni. ACS Infect Dis. 2020;6(7):1922-1927. DOI: 10.1021/acsinfecdis.0c00175

2020
Journal Article
PubMed (32364372)

Keller L, Palmeirim M.S, Ame S.M, Ali S.M, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuris trichiura in adolescents: a randomized controlled trial. Clin Infect Dis. 2020;70(6):1193-1201. DOI: 10.1093/cid/ciz326

2020
Journal Article
PubMed (31044235)

Levecke B, Cools P, Albonico M, Ame S, Angebault C, Ayana M, Behnke J.M, Bethony J.M, Cringoli G, Dana D, Guillard B, Viet Hoa N.T, Kang G, Kattula D, Keiser J, Kotze A.C, Matoso L.F, Maurelli M.P, McCarthy J.S, Mekonnen Z, Mirams G, Montresor A, Oliveira R.C, Periago M.V, Pinto S.A, Rinaldi L, Sayasone S, Sumo L, Tchuem-Tchuente L.A, Cam Thach D.T, Thomas E, Zeynudin A, Verweij J.J, Vlaminck J, Vercruysse J. Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR. PLoS Negl Trop Dis. 2020;14(7):e0008296. DOI: 10.1371/journal.pntd.0008296

2020
Journal Article
PubMed (32614828)
Link

Lin Y, Ong Y.C, Keller S, Karges J, Bouchene R, Manoury E, Blacque O, Müller J, Anghel N, Hemphill A, Häberli C, Taki A.C, Gasser R.B, Cariou K, Keiser J, Gasser G. Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole. Dalton Trans. 2020;49(20):6616-6626. DOI: 10.1039/d0dt01107j

2020
Journal Article
PubMed (32347259)

Moser W, Keiser J, Speich B, Sayasone S, Knopp S, Hattendorf J. One mean to rule them all? The arithmetic mean based egg reduction rate can be misleading when estimating anthelminthic drug efficacy in clinical trials. PLoS Negl Trop Dis. 2020;14(4):e0008185. DOI: 10.1371/journal.pntd.0008185

2020
Journal Article
PubMed (32267856)
Link

Olliaro P.L, Coulibaly J.T, Garba A, Halleux C, Keiser J, King C.H, Mutapi F, N'Goran E.K, Raso G, Scherrer A.U, Sousa-Figueiredo J.C, Stete K, Utzinger J, Vaillant M.T. Efficacy and safety of single 40 mg/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: an individual participant data meta-analysis. PLoS Negl Trop Dis. 2020;14(6):e0008277. DOI: 10.1371/journal.pntd.0008277

2020
Journal Article
PubMed (32569275)
Link

Palmeirim M.S, Bosch F, Ame S.M, Ali S.M, Hattendof J, Keiser J. Efficacy, safety and acceptability of a new chewable formulationversusthe solid tablet of mebendazole against hookworm infections in children: an open-label, randomized controlled trial. EClinicalMedicine. 2020(in press). DOI: 10.1016/j.eclinm.2020.100556

2020
Journal Article
Link

Palmeirim M.S, Ross A, Obrist B, Mohammed U.A, Ame S.M, Ali S.M, Keiser J. Informed consent procedure in a double blind randomized anthelminthic trial on Pemba Island, Tanzania: do pamphlet and information session increase caregivers knowledge?. BMC Med Ethics. 2020;21:1. DOI: 10.1186/s12910-019-0441-3

2020
Journal Article
PubMed (31906925)
Link

Patel C, Coulibaly J.T, Hofmann D, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of albendazole in hookworm-infected preschool-aged children, school-aged children and adults in Cote d'Ivoire: a phase II randomized controlled dose-finding trial. Clin Infect Dis. 2020(in press). DOI: 10.1093/cid/ciaa989

2020
Journal Article
PubMed (32668456)
Link

Patel C, Coulibaly J.T, Schulz J.D, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of albendazole against Trichuris trichiura in preschool-aged children, school-aged children and adults: a multi-cohort randomized controlled trial. EClinicalMedicine. 2020;22:100335. DOI: 10.1016/j.eclinm.2020.100335

2020
Journal Article
PubMed (32405623)
Link

Probst A, Häberli C, Siegel D, Huang J, Vigneron S, Ta A.P, Skinner D.E, El-Sakkary N, Momper J.D, Gangoiti J, Dong Y, Vennerstrom J.L, Charman S.A, Caffrey C.R, Keiser J. Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone. J Antimicrob Chemother. 2020:dkaa247. DOI: 10.1093/jac/dkaa247

2020
Journal Article
PubMed (32617557)

Ravaynia P.S, Lombardo F.C, Biendl S, Dupuch M.A, Keiser J, Hierlemann A, Modena M.M. Parallelized impedance-based platform for continuous dose-response characterization of antischistosomal drugs. Adv Biosyst. 2020;4(7):e1900304. DOI: 10.1002/adbi.201900304

2020
Journal Article
PubMed (32510834)

Vlaminck J, Cools P, Albonico M, Ame S, Ayana M, Dana D, Keiser J, Matoso L.F, Montresor A, Mekonnen Z, Correa-Oliveira R, Pinto S.A, Sayasone S, Vercruysse J, Levecke B. An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections. PLoS Negl Trop Dis. 2020;14(9):e0008625. DOI: 10.1371/journal.pntd.0008625

2020
Journal Article
PubMed (32956390)
Link

Vlaminck J, Cools P, Albonico M, Ame S, Chanthapaseuth T, Viengxay V, Do Trung D, Osei-Atweneboana M.Y, Asuming-Brempong E, Jahirul Karim M, Al Kawsar A, Keiser J, Khieu V, Faye B, Turate I, Mbonigaba J.B, Ruijeni N, Shema E, Lucianez A, Santiago Nicholls R, Jamsheed M, Mikhailova A, Montresor A, Mupfasoni D, Yajima A, Ngina Mwinzi P, Gilleard J, Prichard R.K, Verweij J.J, Vercruysse J, Levecke B. Piloting a surveillance system to monitor the global patterns of drug efficacy and the emergence of anthelmintic resistance in soil-transmitted helminth control programs: a Starworms study protocol. Gates Open Res. 2020;4:28. DOI: 10.12688/gatesopenres.13115.1

2020
Journal Article
PubMed (32266328)
Link

Wagner-Hattler L, Quebatte G, Keiser J, Schoelkopf J, Schleputz C.M, Huwyler J, Puchkov M. Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering. Int J Pharm. 2020;573:118827. DOI: 10.1016/j.ijpharm.2019.118827

2020
Journal Article
PubMed (31756443)

Wu J, Wang X, Chiu F.C.K, Häberli C, Shackleford D.M, Ryan E, Kamaraj S, Bulbule V.J, Wallick A.I, Dong Y, White K.L, Davis P.H, Charman S.A, Keiser J, Vennerstrom J.L. Structure-activity relationship of antischistosomal ozonide carboxylic acids. J Med Chem. 2020;63(7):3723-3736. DOI: 10.1021/acs.jmedchem.0c00069

2020
Journal Article
PubMed (32134263)

Zanolla D, Hasa D, Arhangelskis M, Schneider-Rauber G, Chierotti M.R, Keiser J, Voinovich D, Jones W, Perissutti B. Mechanochemical formation of racemic praziquantel hemihydrate with improved biopharmaceutical properties. Pharmaceutics. 2020;12(3):289. DOI: 10.3390/pharmaceutics12030289

2020
Journal Article
PubMed (32210129)
Link

Albertini B, Perissutti B, Bertoni S, Zanolla D, Franceschinis E, Voinovich D, Lombardo F, Keiser J, Passerini N. Combining mechanochemistry and spray congealing for new praziquantel pediatric formulations in schistosomiasis treatment. Int J Mol Sci. 2019;20(5):1233. DOI: 10.3390/ijms20051233

2019
Journal Article
PubMed (30870971)
Link

Bogoch I.I, Speich B, Lo N.C, Moser W, Croll D, Ali S.M, Ame S.M, Utzinger J, Andrews J.R, Keiser J. Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania. PLoS Negl Trop Dis. 2019;13(7):e0007581. DOI: 10.1371/journal.pntd.0007581

2019
Journal Article
PubMed (31306433)
Link

Brecht K, Kirchhofer C, Bouitbir J, Trapani F, Keiser J, Krähenbühl S. Exogenous iron increases fasciocidal activity and hepatocellular toxicity of the synthetic endoperoxides OZ78 and MT04. Int J Mol Sci. 2019;20(19):E4880. DOI: 10.3390/ijms20194880

2019
Journal Article
PubMed (31581457)
Link

Brussee J.M, Schulz J.D, Coulibaly J.T, Keiser J, Pfister M. Ivermectin dosing strategy to achieve equivalent exposure coverage in children and adults. Clin Pharmacol Ther. 2019;106(3):661-667. DOI: 10.1002/cpt.1456

2019
Journal Article
PubMed (30993667)

Cools P, Vlaminck J, Albonico M, Ame S, Ayana M, Jose Antonio B.P, Cringoli G, Dana D, Keiser J, Maurelli M.P, Maya C, Matoso L.F, Montresor A, Mekonnen Z, Mirams G, Correa-Oliveira R, Pinto S.A, Rinaldi L, Sayasone S, Thomas E, Verweij J.J, Vercruysse J, Levecke B. Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries. PLoS Negl Trop Dis. 2019;13(8):e0007446. DOI: 10.1371/journal.pntd.0007446

2019
Journal Article
PubMed (31369558)
Link

Coulibaly J.T, Hiroshige N, N'Gbesso Y.K, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of tribendimidine against hookworm infections in children: a randomized controlled trial. Clin Infect Dis. 2019;69(5):845-852. DOI: 10.1093/cid/ciy999

2019
Journal Article
PubMed (30496350)

Hürlimann E, Keiser J. A single dose of ivermectin is sufficient for strongyloidiasis. Lancet Infect Dis. 2019;19(11):1150-1151. DOI: 10.1016/S1473-3099(19)30519-5

2019
Journal Item
PubMed (31558377)

Karpstein T, Pasche V, Häberli C, Scandale I, Neodo A, Keiser J. Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections. Parasit Vectors. 2019;12:226. DOI: 10.1186/s13071-019-3476-x

2019
Journal Article
PubMed (31088525)
Link

Keiser J, Utzinger J. Community-wide soil-transmitted helminth treatment is equity-effective. Lancet. 2019;393(10185):2011-2012. DOI: 10.1016/S0140-6736(18)32981-7

2019
Journal Item
PubMed (31006574)
Link

Kyne G.M, Curtis M.P, Keiser J, Woods D.J. Soil-transmitted helminthiasis - challenges with discovery of novel anthelmintics. In: Swinney D.C,Pollastri M.P, eds. Neglected tropical diseases: drug discovery and development. 77, 227-251. Weinheim: Wiley, 2019. DOI: 10.1002/9783527808656.ch9

2019
Book Section

Le T.G, Kundu A, Ghoshal A, Nguyen N.H, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B.C.H, Garcia-Bustos J, Wells T.N.C, Palmer M.J, Jabbar A, Gasser R.B, Baell J.B. Structure–activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of Haemonchus contortus development. J Med Chem. 2019;62(2):1036-1053. DOI: 10.1021/acs.jmedchem.8b01789

2019
Journal Article
PubMed (30571110)

Le T.G, Kundu A, Ghoshal A, Nguyen N.H, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B.C.H, Garcia-Bustos J, Wells T.N.C, Palmer M.J, Jabbar A, Gasser R.B, Baell J.B. Novel 1-methyl-1 H-pyrazole-5-carboxamide derivatives with potent anthelmintic activity. J Med Chem. 2019;62(7):3367-3380. DOI: 10.1021/acs.jmedchem.8b01790

2019
Journal Article
PubMed (30875218)

Lombardo F.C, Pasche V, Panic G, Endriss Y, Keiser J. Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni. Nat Protoc. 2019;14(2):461-481. DOI: 10.1038/s41596-018-0101-y

2019
Journal Article
PubMed (30610241)

Lombardo F.C, Perissutti B, Keiser J. Activity and pharmacokinetics of a praziquantel crystalline polymorph in the Schistosoma mansoni mouse model. Eur J Pharm Biopharm. 2019;142:240-246. DOI: 10.1016/j.ejpb.2019.06.029

2019
Journal Article
PubMed (31265895)

Maccesi M, Aguiar P.H.N, Pasche V, Padilla M, Suzuki B.M, Montefusco S, Abagyan R, Keiser J, Mourao M.M, Caffrey C.R. Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery. Parasit Vectors. 2019;12:493. DOI: 10.1186/s13071-019-3747-6

2019
Journal Article
PubMed (31640761)
Link

Mayoka G, Keiser J, Häberli C, Chibale K. Structure–activity relationship and in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies of N-aryl 3-trifluoromethyl pyrido[1,2-a]benzimidazoles that are efficacious in a mouse model of schistos. ACS Infect Dis. 2019;5(3):418-429. DOI: 10.1021/acsinfecdis.8b00313

2019
Journal Article
PubMed (30580519)

Meister I, Assawasuwannakit P, Vanobberghen F, Penny M, Odermatt P, Sayasone S, Huwyler J, Tarning J, Keiser J. Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections. Antimicrob Agents Chemother. 2019;63(4):e01391-18. DOI: 10.1128/AAC.01391-18

2019
Journal Article
PubMed (30718244)
Link