Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (Publications)
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of acti
Antimalarial <em>N</em>1,<em>N</em>3-dialkyldioxonaphthoimidazoliums: synthesis, biological activity, and structure-activity relationships (Publications)
Here we report the nanomolar potencies of N (1),N (3)-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant Plasmodium falciparum. Activity was dependent on the presence of
Impact of a complex gender-transformative intervention on maternal and child health outcomes in the eastern Democratic Republic of Congo: protocol of... (Publications)
BACKGROUND: In the eastern part of the Democratic Republic of Congo (DRC) Village Savings and Loan Associations (VSLAs) programs targeting women are implemented. In the context of the 'Mawe Tatu' prog
Leprosy post-exposure prophylaxis with single-dose rifampicin: toolkit for implementation (Publications)
lNLR, Amsterdam, NetherlandsmPrivate, UKnHealth Services, Dadra and Nagar Haveli, IndiaoNLR, Jakarta, IndonesiapAnti-Leprosy Campaign, Colombo, Sri LankaqUniversidade do Estado de Mato Grosso, Ca ́cer
Correlates and outcomes of low physical activity posttransplant: a systematic review and meta-analysis (Publications)
BACKGROUND: Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examin
High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania - a prospective cohort study (Publications)
BACKGROUND: Poor adherence to antiretroviral drugs and viral resistance are the main drivers of treatment failure in HIV-infected patients. In sub-Saharan Africa, avoidance of treatment failure on sec
The effects of medicines availability and stock-outs on household's utilization of healthcare services in Dodoma region, Tanzania (Publications)
Low- and middle-income countries have been undertaking health finance reforms to address shortages of medicines. However, data are lacking on how medicine availability and stock-outs influence access
Assessing the quality of cause of death data in six high-income countries: Australia, Canada, Denmark, Germany, Japan and Switzerland (Publications)
OBJECTIVES: To assess the policy utility of national cause of death (COD) data of six high-income countries with highly developed health information systems. METHODS: National COD data sets from Austr