Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth (Publications)
Co-infection by multiple parasites is common within individuals. Interactions between co-infecting parasites include resource competition, direct competition and immune-mediated interactions and each
Metabolic characterization of <em>Leishmania major</em> infection in activated and nonactivated macrophages (Publications)
Infection with Leishmania spp. can lead to a range of symptoms in the affected individual, depending on underlying immune-metabolic processes. The macrophage activation state hereby plays a key role.
Metabolic, immune, and gut microbial signals mount a systems response to <em>Leishmania major</em> infection (Publications)
Parasitic infections such as leishmaniasis induce a cascade of host physiological responses, including metabolic and immunological changes. Infection with Leishmania major parasites causes cutaneous l
Metabolism of (<em>R</em>)-praziquantel versus the activation of a Parasite Transient Receptor Potential Melastatin ion channel (Publications)
Praziquantel (PZQ) is an essential anthelmintic drug recently established to be an activator of a Transient Receptor Potential Melastatin (TRPM(PZQ) ) ion channel in trematode worms. Bioinformatic, mu
Opportunities and challenges for decentralised clinical trials in sub-Saharan Africa: a qualitative study (Publications)
INTRODUCTION: Digital health has gained traction in research and development, and clinical decision support systems. The COVID-19 pandemic accelerated the adoption of decentralised clinical trials (DC
Antibody and B cell responses to SARS-CoV-2 infection and vaccination: the end of the beginning (Publications)
As the COVID-19 pandemic has evolved during the past years, interactions between human immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective vaccines have complicated
Reflections on the impact and response to the Peruvian 2017 coastal El Niño event: looking to the past to prepare for the future (Publications)
Climate-related phenomena in Peru have been slowly but continuously changing in recent years beyond historical variability. These include sea surface temperature increases, irregular precipitation pat
Farmers' valuation and willingness to pay for vaccines to protect livestock resources against priority infectious diseases in Ghana (Publications)
INTRODUCTION: Livestock vaccination coverage rates remain low in many lower and middle income countries despite effective vaccines being commonly available. Consequently, many preventable infectious l