Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and <em>in vivo</em> efficacy in a... (Publications)
Iterative medicinal chemistry optimization of an ester-containing astemizole (AST) analogue 1 with an associated metabolic instability liability led to the identification of a highly potent 3-trifluor
<em>Plasmodium falciparum</em> sexual commitment rate variation among clinical isolates and diverse laboratory-adapted lines (Publications)
Asexual blood-stage malaria parasites must produce sexual progeny to infect mosquitoes. It is important to understand the scope and causes of intraspecific variation in sexual commitment rates, partic
New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies (Publications)
MMV’s Malaria Box compound MMV030666 shows multi-stage activity against various strains of Plasmodium falciparum and lacks resistance development. To evaluate the importance of its diarylether partial
"It's the poverty": stakeholder perspectives on barriers to secondary education in rural Burkina Faso (Publications)
Universal primary and secondary education is a key target of the Sustainable Development Goals. While substantial gains have been made at the primary school level, progress towards universal secondary
Evaluation of the diagnostic performance of PanbioTM Abbott SARS-CoV-2 rapid antigen test for the detection of COVID-19 from suspects attending ALERT... (Publications)
BACKGROUND: The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially lethal disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing publi
Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by <em>Trypanosoma brucei gambiense</em>: a multicentre,... (Publications)
Summary Background Human African trypanosomiasis caused by Trypanosoma brucei gambiense (gambiense HAT) in patients with late-stage disease requires hospital admission to receive nifurtimox–eflornithi