<em>Plasmodium falciparum</em>: malaria morbidity is associated with specific merozoite surface antigen 2 genotypes (Publications)
vaccine against blood stage malaria. In order to test if a specific genotype of the highly polymorphic MSA2 is associated with disease, we conducted a case-control study in a malaria endemic area of Papua New [...] as likely to be found in symptomatic malaria cases than in asymptomatic controls. Mixed genotype infections were significantly less frequent in symptomatic malaria infections. One individual allele (WOS10) [...] to lack of immunity to it. This study provides evidence that MSA2 is...
Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against <em>Plasmodium falciparum</em> and <em>P. vivax malaria</em> in... (Publications)
against uncomplicated malaria in 2000. The purpose of this study was to monitor in vivo efficacy of the current standard combination therapy against Plasmodium falciparum and P. vivax malaria. Studies were conducted [...] vivax malaria was 12%. Our results suggest that the current first-line treatment in Papua New Guinea is not sufficiently effective. According to the new WHO guidelines for the treatment of malaria, a rate [...] seven years of age with clinically overt and parasitologically...
Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment (Publications)
Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115) or three (n =
Complement factor D, albumin, and immunoglobulin G anti-band 3 protein antibodies mimic serum in promoting rosetting of malaria-infected red blood... (Publications)
blood cells (parasitized RBC [pRBC]) with uninfected RBC has been associated in many studies with malaria morbidity and is one form of cytoadherence observed with malarial parasites. Rosetting is serum dependent
Evidence of HLA class II association with antibody response against the malaria vaccine SPF66 in a naturally exposed population (Publications)
The antibody response against the malaria vaccine SPf66 and against circumsporozoite (CS) protein has been tested in immune adults from a malaria endemic area in Papua New Guinea. All individuals were
The contribution of health-care services to a sound and sustainable malaria-control policy (Publications)
efforts to control malaria and other diseases without taking into account health-system performance and sustainability. Even assuming that the Global Fund to Fight AIDS, Tuberculosis, and Malaria (GFATM)--a recent [...] HIV and AIDS, tuberculosis, and malaria, besides presenting a large mortality and morbidity burden in developing countries, are also responsible for poor economic development. In the past international
Insecticide-treated bednets and curtains for preventing malaria (Publications)
BACKGROUND: Malaria is an important cause of illness and death in many parts of the world, especially in Africa. There has been a renewed emphasis on preventive measures, both at community and at individual [...] of this review was to assess the effects of insecticide-treated bednets or curtains in preventing malaria SEARCH STRATEGY: We searched the Cochrane Infectious Diseases Group trials register, Medline, Embase [...] Insecticide-treated nets appear to be effective in reducing childhood...