Increased use of malaria rapid diagnostic tests improves targeting of anti-malarial treatment in rural Tanzania: implications for nationwide rollout... (Publications)
Health Organization recommends parasitological confirmation of all malaria cases. Tanzania is implementing a phased rollout of malaria rapid diagnostic tests (RDTs) for routine use in all levels of care [...] confirmation of malaria diagnosis. This study was carried out to evaluated artemisinin combination therapy (ACT) prescribing patterns in febrile patients with and without uncomplicated malaria in one pre-RDT [...] and low malaria transmission seasons in 2010 in both areas. Clinical...
Geographical patterns and predictors of malaria risk in Zambia: Bayesian geostatistical modelling of the 2006 Zambia national malaria indicator survey... (Publications)
BACKGROUND: The Zambia Malaria Indicator Survey (ZMIS) of 2006 was the first nation-wide malaria survey, which combined parasitological data with other malaria indicators such as net use, indoor residual [...] parasitaemia risk and environmental/climatic predictors of malaria. A number of models were fitted to capture the (potential) non-linearity in the malaria-environment relation and to identify the elapsing time [...] overview of the malaria situation in Zambia. These maps can assist to...
Constructing a malaria-related health service readiness index and assessing its association with child malaria mortality: an analysis of the Burkina... (Publications)
services. We constructed a readiness index related to malaria services and determined the association between health facility malaria readiness and malaria mortality in children under the age of 5 years in [...] l models with variable selection were fitted to malaria mortality data. The most important facility readiness indicators related to general and malaria-specific services were determined. Multiple corr [...] the low readiness group. Medical centres readiness was not related to malaria...
Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a... (Publications)
BACKGROUND: The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization [...] compared to control. According to protocol population, vaccine efficacy against multiple episodes of malaria disease was 50.7% (95% CI: -6.5 to 77.1, p = 0.072) and 26.7% (95% CI: -33.1 to 59.6, p = 0.307) [...] to Treat population, over the 20-month follow up, vaccine efficacy against...
The incidence of malaria in travellers to South-East Asia: is local malaria transmission a useful risk indicator? (Publications)
strategy of using malaria transmission in a local population was an accurate estimate of the malaria threat faced by travellers and a correlate of malaria in returning travellers. METHODS: Malaria endemicity [...] the period 2003-2008 from regionally reported cases to WHO offices. Travel acquired malaria was collated from malaria surveillance reports from the USA and 12 European countries over the same period. The [...] countries, mean malaria rates in endemic countries ranged between 0.01 in...
Potential for reduction of burden and local elimination of malaria by reducing <em>Plasmodium falciparum</em> malaria transmission: a mathematical... (Publications)
a mathematical model of the transmission of Plasmodium falciparum malaria to explore the potential effect on case incidence and malaria mortality rates from 2015 to 2030 of five different intervention [...] BACKGROUND: Rapid declines in malaria prevalence, cases, and deaths have been achieved globally during the past 15 years because of improved access to first-line treatment and vector control. We aimed [...] with a switch from quinine to injectable artesunate for management of severe disease...
Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research Network (Publications)
and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network [...] network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second [...] methods commonly used in malaria epidemiology and population genetics....
Spatially explicit burden estimates of malaria in Tanzania: Bayesian geostatistical modeling of the malaria indicator survey data (Publications)
A national HIV/AIDS and malaria parasitological survey was carried out in Tanzania in 2007-2008. In this study the parasitological data were analyzed: i) to identify climatic/environmental, socio-economic [...] omic and interventions factors associated with child malaria risk and ii) to produce a contemporary, high spatial resolution parasitaemia risk map of the country. Bayesian geostatistical models were fitted [...] association between parasitaemia risk and its determinants. Bayesian kriging...