Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
clinical malaria in which parasites matched the vaccine in the entire circumsporozoite protein C-terminal (139 infections), as compared with 33.4% (95% CI, 29.3 to 37.2) against mismatched malaria (1951 [...] age, the RTS,S vaccine has greater activity against malaria parasites with the matched circumsporozoite protein allele than against mismatched malaria. The overall vaccine efficacy in this age category [...] protein of Plasmodium falciparum and has partial protective efficacy against...
No fever, no malaria? A diagnostic challenge in an immunocompromised patient (Publications)
women with proven malaria tropicana. Fever was not reported with this patient. We conclude that the concept of using fever as a primary surrogate indicator for the presence of malaria should be used with
Cost-effectiveness of the introduction of a pre-erythrocytic malaria vaccine into the expanded program on immunization in Sub-Saharan Africa: analysis... (Publications)
OBJECTIVE: To evaluate the cost-effectiveness of introducing the RTS,S malaria vaccine into the Expanded Programme on Immunization (EPI) in Sub-Saharan Africa (SSA), the contributions of different sources
Accuracy of malaria diagnosis by microscopy, rapid diagnostic test, and PCR methods and evidence of antimalarial overprescription in non-severe... (Publications)
The study was aimed to evaluate the malaria over/underdiagnosis and over/underprescription of antimalarial drugs. Between February and March 2007 blood samples were collected from 336 non-severe febrile [...] Infectious Diseases Lazzaro Spallanzani (INMI), Rome, Italy. As a result of PCR, we identified 26 malaria cases out of 336 (7.7%) patients. Microscopy and RDT accuracies were 93.5% and 97.6%, respectively [...] were 29.3% and 30.8%, respectively. On-field training, clinical management of...
Comparison of the Paracheck-Pf test with microscopy, for the confirmation of <em>Plasmodium falciparum</em> malaria in Tanzania (Publications)
Tanzania, four of which experience frequent malaria outbreaks. The aim was to verify whether Paracheck-Pf could be a reliable tool for the confirmation of malaria outbreaks in such areas. The overall measurements [...] detection of malaria outbreaks. The cost of the assay (U.S.$0.62/test at the time of the present study) is sufficiently low that its routine use in the confirmation of P. falciparum malaria might also be [...] positive predictive value of 88.9%, and a negative predictive value of...