Challenges in malaria management and a glimpse at some nanotechnological approaches (Publications)
formulate a potent malaria vaccine need to be addressed with new strategies to achieve the final goal of malaria eradication. Nanotechnology-researching and designing innovative structures at the nanoscale-is [...] the case of malaria, nanotechnology provides tools to design strategies to target drug molecules to specific stages of the parasite, treat drug-resistant parasites, resolve severe malaria, increase vaccine [...] vaccine efficacies and combinations thereof. This chapter introduces mala...
Identification of fast-acting 2,6-disubstituted imidazopyridines that are efficacious in the <em>In Vivo</em> humanized <em>Plasmodium falciparum</em>... (Publications)
Optimization of a chemical series originating from whole-cell phenotypic screening against the human malaria parasite, Plasmodium falciparum, led to the identification of two promising 2,6-disubstituted im [...] properties, translated to in vivo efficacy with clearance of parasites in the PfSCID mouse model for malaria within 48 h of treatment.
Appropriateness of malaria diagnosis and treatment for fever episodes according to patient history and anti-malarial blood measurement: a... (Publications)
survey took place between May and August 2015 in three regions of Tanzania with different levels of malaria endemicity. Interviews were conducted and blood samples were collected by dried blood spots through [...] testing when individuals attended care was defined as a patient with history of fever being tested for malaria and appropriate treatment as (i) having anti-malarial in the blood if the test result was positive [...] care and improve compliance to test result in order to target febrile...
Impact of climate variability on the transmission risk of malaria in northern Côte d'Ivoire (Publications)
climate patterns might affect the transmission of malaria. The purpose of this study was to analyze climate and environmental parameters associated with malaria transmission in Korhogo, a city in northern Cote [...] (95% CI: 0.1 to 6.7%) in clinical malaria episodes. A 0.1 unit increase in monthly NDVI was associated with a 7.3% (95% CI: 0.8 to 14.1%) increase in the monthly malaria count. There was a similar increase [...] 2.3% to 11.2%)). The study results can be used to establish a malaria...
Safety, immunogenicity, and protective efficacy against controlled human malaria infection of<em> Plasmodium falciparum</em> sporozoites vaccine in... (Publications)
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ) (PfSPZ Challenge) to try to reduce time [...] time and costs of developing PfSPZ Vaccine to prevent malaria in Africa. Immunization with five doses at 0, 4, 8, 12, and 20 weeks of 2.7 x 10(5) PfSPZ of PfSPZ Vaccine gave 65% vaccine efficacy (VE) at [...] and controls. Antibody responses to Pf circumsporozoite protein were...