Determinants of the cost-effectiveness of intermittent preventive treatment for malaria in infants and children (Publications)
seasonality, proportions of malaria fevers treated and drug characteristics. METHODS: We use a dynamic, individual-based simulation model of Plasmodium falciparum malaria epidemiology, antimalarial drug [...] preventive treatment in infants (IPTi) and children (IPTc) have shown promising results in reducing malaria episodes but with varying efficacy and cost-effectiveness. The effects of different intervention [...] g and more expensive drugs, high frequencies of drug resistance and high levels...
Safety of falciparum malaria diagnostic strategy based on rapid diagnostic tests in returning travellers and migrants: a retrospective study (Publications)
developed severe malaria while 6/137 of both RDT and BS positive did so. The use of RDT allowed a reduction of a median of 2.1 hours to get a first malaria test result.CONCLUSIONS: A malaria diagnostic strategy [...] tests for malaria (RDT) allow accurate diagnosis and prompt treatment. Validation of their usefulness in travellers with fever was needed. The safety of a strategy to diagnose falciparum malaria based on [...] those, 2/2028 (0.1%) developed uncomplicated malaria with both RDT and BS...
Experience and challenges from clinical trials with malaria vaccines in Africa (Publications)
clinical trials and malaria control programmes as part of the Global Malaria Action Plan (GMAP). GMAP outlined and support global strategies toward the elimination and eradication of malaria in many areas, [...] Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort [...] Despite this, there is currently no licensed malaria vaccine. Researchers,...
Reduced risk of <em>Plasmodium vivax</em> malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control... (Publications)
protection against P. vivax malaria by a mechanism that is independent of the Duffy antigen. P. vivax malaria may have contributed to shaping the unique host genetic adaptations to malaria in Asian and Oceanic [...] a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Delta27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is unknown whether this polymorphism also protects against
Malaria knowledge and long-lasting insecticidal net use in rural communities of central Côte d'Ivoire (Publications)
BACKGROUND: To improve effectiveness of malaria control interventions, it is essential to deepen the knowledge of contextual factors that govern people's practice for preventive and curative measures. [...] N'Dakonankro and Yoho) located in central Cote d'Ivoire. Indicators of socioeconomic position (SEP), malaria knowledge and practice, placing special emphasis on LLINs, were investigated during a cross-sectional [...] were used, as appropriate. RESULTS: Significant differences were found...
Ensemble modeling of the likely public health impact of a pre-erythrocytic malaria vaccine (Publications)
BACKGROUND: The RTS,S malaria vaccine may soon be licensed. Models of impact of such vaccines have mainly considered deployment via the World Health Organization's Expanded Programme on Immunization (EPI)
<em>Anopheles plumbeus</em> (Diptera: Culicidae) in Europe: a mere nuisance mosquito or potential malaria vector? (Publications)
of humans between Europe and malaria endemic countries and changes in environment and climate, these data strongly suggest that An. plumbeus could act as a vector for malaria and thus significantly contribute [...] to increasing the malaria transmission risk in Central-Western Europe. In locations showing high vulnerability to the presence of gametocyte carriers, the risk of transmission of malaria by An. plumbeus [...] ABSTRACT: BACKGROUND: Anopheles plumbeus has been recognized as a minor...
Efficacy and safety of dihydroartemisinin-piperaquine for treatment of <em>Plasmodium vivax</em> malaria in endemic countries: meta-analysis of... (Publications)
the efficacy of dihydroartemisinin-piperaquine (DHP) in treating uncomplicated Plasmodium vivax malaria in people living in endemic countries. METHODOLOGY AND PRINCIPAL FINDINGS: This is a meta-analysis [...] Findings document that DHP is more efficacious than CQ and AL in treating uncomplicated P. vivax malaria. The better safety profile of DHP and the once-daily dosage improves adherence, and its fixed co [...] the potential to become an alternative antimalarial drug for the treatment...
Orally active antischistosomal early leads identified from the open access malaria box (Publications)
drugs. METHODOLOGY: We studied the antischistosomal properties of the Medicines for Malaria Venture (MMV) malaria box containing 200 diverse drug-like and 200 probe-like compounds with confirmed in vitro [...] respectively. CONCLUSIONS/SIGNIFICANCE: The two candidates identified by investigating the MMV malaria box are characterized by good pharmacokinetic profiles, low cytotoxic potential and easy chemistry
Malaria case management in Papua New Guinea following the introduction of a revised treatment protocol (Publications)
fever or suspected malaria patients and via an interviewer administered questionnaire completed with the officer in charge of each participating health care facility. RESULTS: Malaria rapid diagnostic tests [...] 445) were tested for malaria by RDT and 39% prescribed an anti-malarial, inclusive of 98.2% of RDT positive patients and 19.8% of RDT negative cases. The availability and use of malaria RDTs was greater in [...] CONCLUSIONS: PNG has achieved high coverage of malaria RDTs and AL at the...