Cost-effectiveness of the introduction of a pre-erythrocytic malaria vaccine into the expanded program on immunization in Sub-Saharan Africa: analysis... (Publications)
OBJECTIVE: To evaluate the cost-effectiveness of introducing the RTS,S malaria vaccine into the Expanded Programme on Immunization (EPI) in Sub-Saharan Africa (SSA), the contributions of different sources
Distribution of malaria exposure in endemic countries in Africa considering country levels of effective treatment (Publications)
BACKGROUND: Malaria prevalence, clinical incidence, treatment, and transmission rates are dynamically interrelated. Prevalence is often considered a measure of malaria transmission, but treatment of clinical [...] clinical malaria reduces prevalence, and consequently also infectiousness to the mosquito vector and onward transmission. The impact of the frequency of treatment on prevalence in a population is generally [...] generally not considered. This can lead to potential underestimation of ma...
Artemether-lumefantrine treatment of uncomplicated <em>Plasmodium falciparum</em> malaria: a systematic review and meta-analysis of day 7 lumefantrine... (Publications)
BACKGROUND: Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well [...] data from patients treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria, to define therapeutic day 7 lumefantrine concentrations and identify patient factors that substantially [...] associated with > 98 % cure rates (if parasitemia /=200 ng/ml and high cure...
Assessment of parental perception of malaria vaccine in Tanzania (Publications)
and willingness to use malaria vaccines and to provide policy makers with evidence-based information on the best strategies to engage communities to manage the introduction of malaria vaccine in Tanzania [...] variables of interests were awareness and willingness to use a malaria vaccine. The main outcome measure was willingness to use a malaria vaccine. Logistic regression was used to examine the influence [...] BACKGROUND: Clinical trials of the RTS,S malaria vaccine have completed Phase III...
Spatial and temporal variation of malaria entomological parameters at the onset of a hydro-agricultural development in central Côte d'Ivoire (Publications)
e heterogeneity of malaria transmission is essential for the design of effective prevention, control and elimination interventions. The spatial and temporal distribution of malaria vectors was investigated [...] correlated with malaria transmission. CONCLUSION: In this study setting, located in the bioclimatic transition zone of Cote d'Ivoire, rice cultivation was not observed to increase malaria transmission. The [...] observed in two of the five villages located in close proximity to the dam...
Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo (Publications)
The Democratic Republic of the Congo (DRC) changed its national policy for the treatment of severe malaria in both children and adults in 2012 from intravenous quinine to injectable artesunate. The country [...] deploy nationwide injectable artesunate as the preferred treatment for the management of severe malaria. To support this process, the feasibility and acceptability of the use of injectable artesunate in [...] CONCLUSIONS: These findings show that the use of injectable artesunate for the...
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and... (Publications)
baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs). METHODS: A literature review in PubMed