Global action for training in malaria elimination [Commentary] (Publications)
The Rethinking Malaria Leadership Forum, held at Harvard Business School in February 2017 with collaboration of the Barcelona Institute for Global Health and the Swiss Tropical and Public Health Institute [...] training gap as a high priority for both analysis and action. The gap in human resource training for malaria elimination needs to be addressed in order to assure continued progress. This paper identifies major [...] assist in filling the training gaps, and proposes global actions to...
Empowering rural communities for effective larval source management: a small-scale field evaluation of a community-led larviciding approach to control... (Publications)
source management, particularly larviciding, is mainly implemented in urban settings to control malaria and other mosquito-borne diseases. In Tanzania, the government has recently expanded larviciding [...] characterize and target larval habitats of Anopheles funestus mosquitoes, the dominant vector of malaria transmission in south-eastern Tanzania. Methods: A mixed-methods study was used. First, intervie [...] community-based volunteers were trained to identify and characterize aquatic habitats...
Forecasting malaria dynamics based on causal relations between control interventions, climatic factors, and disease incidence in western Kenya (Publications)
drivers and investigate their effects, interaction strength, and suitability ranges on malaria incidence. Monthly malaria cases were collected at St. Elizabeth Lwak Mission Hospital. Intervention coverage [...] Short-term forecasting of malaria incidence was performed using state-space reconstruction. RESULTS: We observed causal links between climatic drivers, bed net use, and malaria incidence. LSTD lagged over [...] BACKGROUND: Malaria remains one of the deadliest diseases worldwide,...
AnophelesModel: an R package to interface mosquito bionomics, human exposure and intervention effects with models of malaria intervention impact (Publications)
semi-field studies of malaria transmission have gathered geographic-specific information about mosquito ecology, behaviour and their sensitivity to interventions. Mathematical models of malaria transmission can [...] incorporate such data to infer the likely impact of vector control interventions and hence guide malaria control strategies in various geographies. To facilitate this process and make model predictions [...] addition, it offers formatted outputs ready to use in downstream analyses...
Malaria rapid tests, febrile illness management, and child mortality across sub-Saharan African countries (Publications)
IMPORTANCE: A prompt malaria diagnosis is crucial for the management of children with febrile illness in sub-Saharan African countries, where malaria remains a leading cause of mortality among children [...] distribution of point-of-care rapid diagnostic tests (RDTs) for malaria has transformed practice, but limited systematic evidence exists on how malaria RDTs have affected the management of febrile illness and [...] deaths per 1000 child-years). The effects of malaria RDT distribution on...
Potential impact of climatic factors on malaria in Rwanda between 2012 and 2021: a time-series analysis (Publications)
change and malaria dynamics, which hinders the development of effective national malaria response strategies. Addressing this critical gap, this study analyses how climatic factors influence malaria transmission [...] BACKGROUND: Malaria remains an important public health problem, particularly in sub-Saharan Africa. In Rwanda, where malaria ranks among the leading causes of mortality and morbidity, disease transmission [...] temperature and cumulative rainfall on malaria incidence in Rwanda from...
Spatio-temporal dynamics of malaria in Rwanda between 2012 and 2022: a demography-specific analysis (Publications)
eventually interrupt malaria transmission, the disease remains a pressing public health problem, especially in sub-Saharan Africa. This study presents a detailed spatio-temporal analysis of malaria transmission [...] insights into the evolving patterns of malaria and to inform and tailor effective public health strategies. METHODS: The study used yearly aggregated data of malaria cases from the Rwanda health management [...] temporal patterns of relative risks and to identify clusters of malaria...
Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage... (Publications)
BACKGROUND: The combination antimalarial artefenomel-piperaquine failed to achieve target efficacy in a phase 2b study in Africa and Vietnam. We retrospectively evaluated whether characterizing the ph