Molecular Immunology | Research at Swiss TPH (Page)
https://www.swisstph.ch/de/about/med/molecular-immunology
vaccine development. Malaria P. falciparum: Developing a Synthetic Subunit Candidate Vaccine Malaria is one of the most serious infectious diseases of humans. New approaches to combat malaria are urgently needed [...] efficacy of therapeutic interventions. This research focuses primarily on three infectious diseases: malaria due to Plasmodium falciparum, bacterial meningitis caused by Neisseria meningitides and Streptococcus [...] developing synthetic peptide structures that induce...
Mathematical Epidemiology (Page)
https://www.swisstph.ch/de/about/eph/disease-modelling/mathematical-epidemiology
Correction: Testing and treatment for malaria elimination: a systematic review. Malar J . 2024;23:63. DOI: 10.1186/s12936-024-04861-x Related Topics Health Interventions Malaria Helminths Human African Trypanosomiasis [...] computational models to improve understanding of population, infection and disease dynamics, focusing on malaria and neglected tropical diseases. Nakul Chitnis PhD, PD Dr. Group Leader +41612848242 nakul.chitn [...] Hofer Lars Kamber Alexis Martin Louis Perriens Taru Singhal...
Drug Discovery Work (Page)
https://www.swisstph.ch/de/about/mpi/parasite-chemotherapy/drug-discovery-work
evaluation of new compounds. The Medicines for Malaria Venture (MMV) Foundation supports the project ‘Syntheticperoxides’ and the new projects ‘Oral diamidines for malaria’. With a master contract with the MMV [...] Drug Discovery Work Tropical parasitic diseases, as malaria, African sleeping sickness, Chagas disease or Leishmaniasis represent still a large health risk for a majority of the worlds population. These [...] trematodes. Links WHO/TDR European COST B22 Drugs for Neglected Diseases...
Ethnobotanical study of some of mosquito repellent plants in north-eastern Tanzania (Publications)
potential for malaria vector control requires evaluation in areas with different level of malaria endemicity. The essential oils of Ocimum suave and Ocimum kilimandscharicum were evaluated against malaria vectors [...] filter papers impregnated with Ocimum extracts, knockdown effects and mortality was investigated on malaria mosquito Anopheles arabiensis and Anopheles gambiae, including a nuisance mosquito, Culex quinqu
Modelling the impact of insecticide-based control interventions on the evolution of insecticide resistance and disease transmission (Publications)
threshold level of mosquitoes below which transmission of malaria is interrupted. It is based on a classic Ross-Macdonald derivation of the malaria basic reproductive number (R0) and may be used to assess [...] (iv) the impact of resistance once it has arisen and, in particular, whether it is sufficient for malaria transmission to resume. The model consists of a system of difference equations that tracks the immature [...] and easily generalizable to many scenarios using different calibrations...
Lack of associations of alpha(+) - thalassemia with the risk of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infection and disease in... (Publications)
unknown. An increase in risk of Plasmodium vivax malaria in early childhood resulting in a cross-species protection against severe P. falciparum malaria has been proposed as a possible mechanism in Melanesian [...] wild-type allele. No significant differences in the incidence of P. falciparum (Pf) or P. vivax (Pv) malaria were observed between alpha(+)-thalassemia homozygote (Pf: Incidence rate ratio (IRR) = 1.13, CI(95) [...] = 0.008). This study therefore failed to confirm an increased risk of...
Lack of associations of alpha(+) - thalassemia with the risk of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infection and disease in... (Publications)
unknown. An increase in risk of Plasmodium vivax malaria in early childhood resulting in a cross-species protection against severe P. falciparum malaria has been proposed as a possible mechanism in Melanesian [...] wild-type allele. No significant differences in the incidence of P. falciparum (Pf) or P. vivax (Pv) malaria were observed between alpha(+)-thalassemia homozygote (Pf: Incidence rate ratio (IRR) = 1.13, CI(95) [...] = 0.008). This study therefore failed to confirm an increased risk of...
Ethnobotanical study of some of mosquito repellent plants in north-eastern Tanzania (Publications)
potential for malaria vector control requires evaluation in areas with different level of malaria endemicity. The essential oils of Ocimum suave and Ocimum kilimandscharicum were evaluated against malaria vectors [...] filter papers impregnated with Ocimum extracts, knockdown effects and mortality was investigated on malaria mosquito Anopheles arabiensis and Anopheles gambiae, including a nuisance mosquito, Culex quinqu
Modelling the impact of insecticide-based control interventions on the evolution of insecticide resistance and disease transmission (Publications)
threshold level of mosquitoes below which transmission of malaria is interrupted. It is based on a classic Ross-Macdonald derivation of the malaria basic reproductive number (R0) and may be used to assess [...] (iv) the impact of resistance once it has arisen and, in particular, whether it is sufficient for malaria transmission to resume. The model consists of a system of difference equations that tracks the immature [...] and easily generalizable to many scenarios using different calibrations...
Disease Modelling and Intervention Dynamics | Swiss TPH (Page)
https://www.swisstph.ch/de/about/eph/disease-modelling/disease-modelling-and-intervention-dynamics
penny@unibas.ch Links Malaria Modelling Resource Centre Key Projects Shaping Next-Generation Interventions for Malaria Prevention Despite progress to reduce malaria burden, malaria parasites are becoming [...] Selected Projects All Projects Mathematical models to define new malaria immunotherapies and interventions to meet public health needs Core Malaria Modelling Mathematical modelling to examine disease, control [...] to address contemporary issues in infectious diseases and global health. We...