Multiplex assay for species identification and monitoring of insecticide resistance in <em>Anopheles punctulatus</em> group populations of Papua New... (Publications)
complex [eight cryptic species]) are principal vectors of malaria and filariasis in the Southwest Pacific. Given significant effort to reduce malaria and filariasis transmission through insecticide-treated
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite Plasmodium falciparum (PfdUTPase)
Discovery and characterization of ACT-451840: an antimalarial drug with a novel mechanism of action (Publications)
More than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub-Saharan Africa, Central and South America, and Asia. Resistance to standard
Prodrugs of reverse fosmidomycin analogues (Publications)
biosynthesis that is essential in Plasmodium falciparum. The drug has been used successfully to treat malaria patients in clinical studies, thus validating IspC as an antimalarial target. However, improvement [...] compounds were also tested for their cytotoxicity toward HeLa cells and in vivo in a Plasmodium berghei malaria model as well as in the SCID mouse P. falciparum model
A novel multiple-stage antimalarial agent that inhibits protein synthesis (Publications)
There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug resistance. Here we describe [...] blocking and chemoprotection. DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which
Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines (Publications)
antiplasmodial activities in vitro and in vivo, even against chloroquine-resistant strains of the malaria pathogen. For the directed optimization of these activities, an investigation of the mode of action [...] their pharmacological potential as a valuable lead structure against the widespread tropical disease malaria
Systematic review of indoor residual spray efficacy and effectiveness against <em>Plasmodium falciparum</em> in Africa (Publications)
Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel [...] of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including
Expert Committee Memberships | Scientific and Policy Advice (Page)
https://www.swisstph.ch/de/about/memberships
Partnership to End Malaria (Coordinator) Multi Sectoral Action Working Group, RBM Partnership to End Malaria (Coordinator) Vector Control Working Group, RBM Partnership to End Malaria (Coordinator) Christian [...] Institute of Medical Research (BC) Fakultätsversammlung Phil Nat Uni Basel WHO Malaria Policy Advisory Committee (MPAG) Zanzibar Malaria Elimination Advisory Committee Jennifer Keiser WHO Advisory Group on So [...] international organisations such as the WHO on evidence-based health...
Medicines Development | Research at Swiss TPH (Page)
https://www.swisstph.ch/de/about/med/medicines-development
platforms, malaria drug resistance genotyping services and the development of vaccines and treatments for tropical infectious diseases. The MDU excels in providing global genotyping services for malaria resistance [...] on diseases such as malaria, respiratory viruses, Buruli ulcer and undifferentiated febrile diseases. Our Core Competencies Our core expertise is in molecular genotyping for malaria drug resistance testing [...] testing, diagnostic development of non-invasive and innovative...
Basic Research in Infection Biology | Swiss TPH (Page)
https://www.swisstph.ch/de/research/basic-research-in-infection-biology
are neglected tropical diseases that affect the poorest communities. Malaria A gametocyte - the sexual form of Plasmodium Malaria is caused by unicellular parasites of the genus Plasmodium , which are [...] Infection Biology conduct cutting-edge basic research on infectious diseases of poverty, including Malaria (caused by Plasmodium spp .) Tuberculosis (caused by Mycobacterium tuberculosis ) Buruli ulcer (caused [...] Mycobacterium ulcerans ) Sleeping sickness/African trypanosomiasis (caused...