Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of beta-hematin formation (Publications)
identification of novel scaffolds for the development of effective and safe treatments to fight malaria is urgently needed. One of the main opportunities is the discovery of new molecules from natural
<em>Plasmodium vivax </em>molecular diagnostics in community surveys: pitfalls and solutions (Publications)
ial DNA-based assay increased prevalence from 4.9 to 6.5%. The usefulness of molecular tests in malaria epidemiological studies is widely recognized, especially when precise prevalence rates are desired
<em>Schistosoma</em>, other helminth infections, and associated risk factors in preschool-aged children in urban Tanzania (Publications)
and performed medical examinations. We performed full blood cell counts and screened for HIV and malaria. Point-of-care circulating cathodic antigen (POC-CCA), urine filtration, Kato-Katz, FLOTAC, and Baermann
Insecticide susceptibility of <em>Anopheles </em>mosquitoes changes in response to variations in the larval environment (Publications)
Insecticide resistance threatens the success achieved through vector control in reducing the burden of malaria. An understanding of insecticide resistance mechanisms would help to develop novel tools and strategies
Target product profile for a diagnostic assay to differentiate between bacterial and non-bacterial infections and reduce antimicrobial overuse in... (Publications)
group, and consensus characteristics were defined. The working group defined non-severely ill, non-malaria infected children as the target population for the desired assay. To provide access to the most patients
Assessing seasonal variations and age patterns in mortality during the first year of life in Tanzania (Publications)
trends. Mortality rates in Sub-Sahara Africa show seasonal patterns due to high infant and child malaria-related mortality which is influenced by seasonal features present in environmental and climatic
<em>In vitro</em> assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of <em>Plasmodium falciparum</em> (Publications)
OBJECTIVES: Using synchronous cultures of Plasmodium falciparum malaria, the stage sensitivity of the parasite to OZ277 (RBx-11160), the first fully synthetic antimalarial peroxide that has entered Phase
MAHRP2, an exported protein of <em>Plasmodium falciparum</em>, is an essential component of Maurer's cleft tethers (Publications)
Summary Upon invasion into erythrocytes, the malaria parasite Plasmodium falciparum must refurbish the host cell. The objective of this study was to elucidate the location and function of MAHRP2 in these
Antitrypanosomal activity of sesquiterpene lactones from <em>Helianthus tuberosus</em> L. including a new furanoheliangolide with an unusual structure (Publications)
(Chagas Disease), Leishmania donovani (Visceral Leishmaniasis) and Plasmodium falciparum (Tropical Malaria) as well as cytotoxicity against rat skeletal myoblasts (L6 cell line) was determined along with
Chemoproteomics validates selective targeting of <em>Plasmodium</em> M1 alanyl aminopeptidase as an antimalarial strategy (Publications)
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metal
