Comparative performance of three experimental hut designs for measuring malaria vector responses to insecticides in Tanzania (Publications)
BACKGROUND: Experimental huts are simplified, standardized representations of human habitations that provide model systems to evaluate insecticides used in indoor residual spray (IRS) and long-lasting
Identification of new human malaria parasite <em>Plasmodium falciparum</em> dihydroorotate dehydrogenase inhibitors by pharmacophore and... (Publications)
Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway, which the Plasmodium falciparum relies on exclusively for survival, has emerg
Critical evaluation of molecular monitoring in malaria drug efficacy trials and pitfalls of length-polymorphic markers (Publications)
therefore calls for necessary amendments to the current WHO recommendations for PCR correction of malaria drug trial endpoints. Accuracy of genotyping outcomes could be improved by separate amplification
Assessing the effects of malaria interventions on the geographical distribution of parasitaemia risk in Burkina Faso (Publications)
nationally representative household malaria survey in 2010/2011. The survey collected among others, information on malaria interventions, treatment choices and malaria parasite prevalence in children aged [...] residual spray (IRS), artemisinin-based combination therapy (ACT) coverage associated with childhood malaria parasite risk at national and sub-national level, after taking into account geographical disparities [...] where interventions are being effective. These outputs are valuable tools...
Policy analysis for deciding on a malaria vaccine RTS,S in Tanzania (Publications)
stakeholders in Tanzania to assess malaria treatment policy changes and to draw lessons for malaria vaccine adoption. RESULTS: The decision-making process for adopting malaria interventions and new vaccines [...] policy makers and stimulate the decision-making process. In the case of the proposed introduction of malaria vaccines in Tanzania, a specific framework for decision-making will speed up the administrative process [...] Promoting factors include; epidemiological and intervention...
Operational strategies of anti-malarial drug campaigns for malaria elimination in Zambia's southern province: a simulation study (Publications)
strategies for parasite clearance in southern province. METHODS: OpenMalaria, a discrete-time, individual-based stochastic model of malaria, was parameterized for the study area to simulate anti-malarial drug [...] BACKGROUND: Malaria elimination requires reducing both the potential of mosquitoes to transmit parasites to humans and humans to transmit parasites to mosquitoes. To achieve this goal in Southern province
Mapping and predicting malaria transmission in the People's Republic of China, using integrated biology-driven and statistical models (Publications)
humidity, which thus determines the extent of malaria transmission. However, in regions with relative humidity > 60%, temperature is the major driver of malaria transmission intensity. By integrating bio [...] The purpose of this study was to deepen our understanding of Plasmodium vivax malaria transmission patterns in the People's Republic of China (P.R. China). An integrated modeling approach was employed [...] and statistical models. A Delphi approach was used to determine environmental...