Impact of changes in detection effort on control of visceral leishmaniasis in the Indian subcontinent (Publications)
is not a reliable indicator of the performance of case detection programs. Duration of symptoms in detected cases can be used as an additional marker of the performance of case detection programs. [...] BACKGROUND: Control of visceral leishmaniasis (VL) on the Indian subcontinent relies on prompt detection and treatment of symptomatic cases. Detection efforts influence the observed VL incidence and how [...] Using a mathematical model for transmission and control of VL, we predict the impact of...
Modulation of host-parasite interactions with small molecules targeting <em>Schistosoma mansoni </em>microRNAs (Publications)
Parasites use different strategies of communication with their hosts. One communication channel that has been studied in recent years is the use of vesicle microRNAs to influence the host immune system by trematodes [...] sma-microRNA-10, secreted from Schistosoma mansoni, has been shown to influence the fate of host T-cells through manipulation of the NF-kappaB pathway. We have identified low molecular weight tool compounds [...] microRNA-mediated manipulation of the host immune system. We...
Modulation of host-parasite interactions with small molecules targeting <em>Schistosoma mansoni </em>microRNAs (Publications)
Parasites use different strategies of communication with their hosts. One communication channel that has been studied in recent years is the use of vesicle microRNAs to influence the host immune system by trematodes [...] sma-microRNA-10, secreted from Schistosoma mansoni, has been shown to influence the fate of host T-cells through manipulation of the NF-kappaB pathway. We have identified low molecular weight tool compounds [...] microRNA-mediated manipulation of the host immune system. We...
Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development (Publications)
development of antimalarial compounds. However, systematic and meaningful translation of drug efficacy and host-parasite dynamics between preclinical testing stages is missing. We developed an ensemble of mathematical [...] extensive data from four antimalarials with different modes of action, to assess host-parasite interactions in two preclinical drug testing systems of murine parasite P. berghei in mice, and human parasite [...] properties of the host-parasite system, namely resource...
Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development (Publications)
development of antimalarial compounds. However, systematic and meaningful translation of drug efficacy and host-parasite dynamics between preclinical testing stages is missing. We developed an ensemble of mathematical [...] extensive data from four antimalarials with different modes of action, to assess host-parasite interactions in two preclinical drug testing systems of murine parasite P. berghei in mice, and human parasite [...] properties of the host-parasite system, namely resource...
Informing new or improved vector control tools for reducing the malaria burden in Tanzania: a qualitative exploration of perceptions of mosquitoes and... (Publications)
BACKGROUND: The effectiveness of malaria prevention with long-lasting insecticidal nets and indoor residual spraying is limited by emerging insecticide resistance, evasive mosquito behaviours that include [...] perceived as a growing problem, directly attributed to widespread environmental deterioration and lack of effective mosquito control interventions. Malaria and nuisance biting were perceived as the main problem [...] window screens, and fumigation, while bed nets were most frequently...
Challenges of DHS and MIS to capture the entire pattern of malaria parasite risk and intervention effects in countries with different ecological... (Publications)
such as the level of mother's education, place of residence and the household welfare were captured by both surveys. CONCLUSION: Timing of the malaria survey influences estimates of the geographical d [...] malaria peak transmission season. This study compares estimates of the geographical distribution of malaria parasite risk and of the effects of interventions obtained from the DHS and MIS survey data. METHODS: [...] altitude as important predictors of the geographical distribution of the...
Development and validation of an LC-MS/MS method for the quantification of the anthelmintic drug moxidectin in a volumetric absorptive microsample,... (Publications)
gradient program of 6 min duration. Validation was performed with respect to accuracy, precision, sensitivity, selectivity, linearity, stability, recovery, and haematocrit influence with a limit of quantification [...] sampling strategies: e.g. identical time to reach maximal concentration of 4.0 h and a similar maximal concentration of 83.9-88.5 ng/mL of moxidectin. The simple and practical capillary procedure using Mitra(R) [...] quantification of moxidectin in human blood obtained by...
European community respiratory health survey II : final report of work package 5 : historic data of ambient air pollution in 37 European cities of... (Publications)
project is the assessment of the natural course of respiratory diseases, paying particular attention to asthma and the change in pulmonary function. The influence of long-term effects of outdoor air pollution [...] adult population of 29 of the original 41 (mostly) European centres of the former ECRHS I cross-sectional study (1989-92) is being re- investigated in a cohort study. The primary goal of the ECRHS II project [...] data is incomplete across Europe 2) several indicators of air pollution...
European community respiratory health survey II : final report of work package 5 : historic data of ambient air pollution in 37 European cities of... (Publications)
project is the assessment of the natural course of respiratory diseases, paying particular attention to asthma and the change in pulmonary function. The influence of long-term effects of outdoor air pollution [...] adult population of 29 of the original 41 (mostly) European centres of the former ECRHS I cross-sectional study (1989-92) is being re- investigated in a cohort study. The primary goal of the ECRHS II project [...] data is incomplete across Europe 2) several indicators of air pollution...