Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of <em>Schistosoma... (Publications)
analysis of S. haematobium. The molecular resources and protocols described here advance the way researchers can perform multi locus-based population genetic analyses of S. haematobium as part of the evaluation [...] and regional elimination. The development of new high-throughput, cost-effective molecular tools and approaches are needed to monitor and evaluate the impact of control programs on the parasite populations [...] microsatellite analysis of S. haematobium larval stages stored on...
High prevalence of nonconvulsive and subtle status epilepticus in an ICU of a tertiary care center: a three-year observational cohort study (Publications)
duration, length of hospital stay, outcome and case fatality rate of status epilepticus in adults in relation to demographic and clinical variables. It was conducted in an intensive care unit of a tertiary care [...] three years. RESULTS: 111 status epilepticus episodes had a median duration of 48h. Hospitalization length was 18+/-15.3 days. 81% of the status epilepticus episodes were nonconvulsive and subtle. Case fatality [...] over 70 years had independent positive influence on status...
Health-related quality of life does not explain the protective effect of farming on allergies (Publications)
in these analyses. Methods: In order to assess the potential influence of health-related quality of life (HRQOL) on the protective effect of farming, 8259 school aged children from the European GABRIEL [...] ated quality of life does not explain the protective effect of farming on allergies. Pediatr Allergy Immunol 2012: 00. ABSTRACT: Background: Numerous studies report a protective effect of farming against [...] not modify the protective effect of farming against allergies. Children with...
Transposition of <em>HOPPLA</em> in siRNA-deficient plants suggests a limited effect of the environment on retrotransposon mobility in... (Publications)
powerful mutagens regarded as a major source of genetic novelty and important drivers of evolution. Yet, the uncontrolled and potentially selfish proliferation of LTR-RTs can lead to deleterious mutations [...] common in many species, the understanding of their dual role in evolution is limited. Here, we harness the genetic diversity of 320 sequenced natural accessions of the Mediterranean grass Brachypodium distachyon [...] environmental factors influence plant LTR-RT dynamics in the wild. When...
An explorative analysis of process and formulation variables affecting comilling in a vibrational mill: the case of praziquantel (Publications)
type) and process parameters (type of grinding media, grinding time and frequency) was carried out with the help of an experimental screening design. The influence of the above mentioned factors on three [...] treatment of schistosome infections, was coground in a vibrational mill with different polymers (linear and crosslinked povidone, copovidone and sodium starch glycolate). An explorative analysis of formulation [...] variation of carrier amount proved to be by far the most important...
Mapping of genotype-phenotype diversity amongst clinical isolates of <em>Mycobacterium tuberculosis</em> by sequence-based transcriptional profiling (Publications)
extensive repertoire of single nucleotide polymorphisms among clinical isolates of Mycobacterium tuberculosis, but the extent to which these differences influence phenotypic properties of the bacteria remains [...] advance our understanding of mycobacterial evolution, contribute to a systems level understanding of this important human pathogen, and more broadly demonstrate the application of state-of-the-art techniques [...] sequence of transcriptional regulators were associated with alterations...
Patterns of exposure to infectious diseases and social contacts in early life and risk of brain tumours in children and adolescents: an International... (Publications)
association with various measures of social contacts: daycare attendance, number of childhours at daycare, attending baby groups, birth order or living with other children.Cases of glioma and embryonal tumours [...] contacts influence childhood and adolescent brain tumour risk. The association between reported sick days due to infections and risk of glioma and embryonal tumour may reflect involvement of immune functions [...] tumours had more frequent sick days with infections in the first 6...
Mapping of genotype-phenotype diversity amongst clinical isolates of <em>Mycobacterium tuberculosis</em> by sequence-based transcriptional profiling (Publications)
extensive repertoire of single nucleotide polymorphisms among clinical isolates of Mycobacterium tuberculosis, but the extent to which these differences influence phenotypic properties of the bacteria remains [...] advance our understanding of mycobacterial evolution, contribute to a systems level understanding of this important human pathogen, and more broadly demonstrate the application of state-of-the-art techniques [...] sequence of transcriptional regulators were associated with alterations...
Patterns of exposure to infectious diseases and social contacts in early life and risk of brain tumours in children and adolescents: an International... (Publications)
association with various measures of social contacts: daycare attendance, number of childhours at daycare, attending baby groups, birth order or living with other children.Cases of glioma and embryonal tumours [...] contacts influence childhood and adolescent brain tumour risk. The association between reported sick days due to infections and risk of glioma and embryonal tumour may reflect involvement of immune functions [...] tumours had more frequent sick days with infections in the first 6...
Clinical trials in low-resource settings: the perspectives of caregivers of paediatric participants from Uganda, Tanzania and Kenya (Publications)
the setting and contextual factors which influence the decision process is necessary. This study investigates the experience of caregivers consenting on behalf of paediatric participants in a malaria vaccine [...] participation enables access to free, high-quality medical care. METHODS: We interviewed a total of 78 caregivers of paediatric participants previously enrolled in a phase II or III malaria vaccine clinical trial [...] focusing on the embodied caregiver in the political, economic and...