Characterization of the population pharmacokinetics of moxidectin in adults infected with <em>Strongyloides stercoralis</em>: support for a fixed-dose... (Publications)
novel candidate for the treatment of helminth infections, including Strongyloides stercoralis. This study aims to characterize the population pharmacokinetics (PPK) of moxidectin in S. stercoralis-infected [...] lag-time best described the available PK data. Allometric scaling was applied to account for the influence of body weight. High clearance was found in the infected adults (4.47 L/h [95% confidence interval [...] phase IIa trial was conducted in NamBak, Laos. Eight micro blood samples...
Beyond antimalarial stock-outs: implications of health provider compliance on out-of-pocket expenditure during care-seeking for fever in south east... (Publications)
public sector health worker behaviour, both of which increase out-of-pocket health expenditure. Interventions are urgently needed to ensure a stable supply of ACT in the public sector and increase health [...] better understand how stock-outs of the first line antimalarial, Artemisinin-based Combination Therapy (ACT) and other non-compliant health worker behaviour, influence household expenditures during ca [...] depending on ACT availability in their nearest health facility. RESULTS:...
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase-2 genes on the metabolism of artemisinin-based... (Publications)
combination therapies, in different populations are needed to evaluate the influence of pharmacogenetic factors on the clearance of antimalarials [...] netics of antimalarials is poorly known, although its application might be critical to optimize treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the effect of single [...] patients treated with dihydroartemisinin-piperaquine. The frequency of SNPs varied with the enzyme and the population. Higher frequencies of...
The practical importance of permanent and semipermanent habitats for controlling aquatic stages of <em>Anopheles gambiae</em> <em>sensu lato</em>... (Publications)
About 70% of all available habitats were man-made, half of them representing cement-lined pits. On average, 67% of all aquatic habitats on a given sampling date were colonized by Anopheles larvae, of which [...] positively correlated with presence of tufts of low vegetation and negatively with non-matted algal content. The permanence of a habitat had no significant influence on larval productivity. We conclude [...] broadly distributed across a variety of habitat types, regardless of permanence....
Studies on the ecology of Bulinus globosus, the intermediate host of <em>Schistosoma haematobium</em> in the Ifakara area, Tanzania (Publications)
limits. No correlation of the distribution of B. globosus and other snail species was found. Rainfall patterns have a distinct influence on snail densities. They determine the duration of desiccation and affect [...] During a period of 2 years, the ecology of Bulinus globosus was studied in 8 habitats in two streams near Ifakara, SE-Tanzania. The relative Bulinus densities were followed monthly. Two different methods [...] affect the snails by fluctuations of the water level and by the fast...
Characterization of the population pharmacokinetics of moxidectin in adults infected with <em>Strongyloides stercoralis</em>: support for a fixed-dose... (Publications)
novel candidate for the treatment of helminth infections, including Strongyloides stercoralis. This study aims to characterize the population pharmacokinetics (PPK) of moxidectin in S. stercoralis-infected [...] lag-time best described the available PK data. Allometric scaling was applied to account for the influence of body weight. High clearance was found in the infected adults (4.47 L/h [95% confidence interval [...] phase IIa trial was conducted in NamBak, Laos. Eight micro blood samples...
"It is difficult for us to treat their pain": health professionals' perceptions of Somali pastoralists in the context of pain management: a conceptual... (Publications)
professionals' perceptions of pain-related care for Somali pastoralists. This study seeks to understand health professionals' perceptions of Somali pastoralists in the context of pain management in Eastern [...] Pain is one of the most neglected areas of care in sub-Saharan Africa. Access to adequate pain management is important, especially in marginalised populations, such as pastoralists. Little is known about [...] model of pastoralist-specific pain management. We gave voice to pastoralists...
Studies on the ecology of Bulinus globosus, the intermediate host of <em>Schistosoma haematobium</em> in the Ifakara area, Tanzania (Publications)
limits. No correlation of the distribution of B. globosus and other snail species was found. Rainfall patterns have a distinct influence on snail densities. They determine the duration of desiccation and affect [...] During a period of 2 years, the ecology of Bulinus globosus was studied in 8 habitats in two streams near Ifakara, SE-Tanzania. The relative Bulinus densities were followed monthly. Two different methods [...] affect the snails by fluctuations of the water level and by the fast...
Beyond antimalarial stock-outs: implications of health provider compliance on out-of-pocket expenditure during care-seeking for fever in south east... (Publications)
public sector health worker behaviour, both of which increase out-of-pocket health expenditure. Interventions are urgently needed to ensure a stable supply of ACT in the public sector and increase health [...] better understand how stock-outs of the first line antimalarial, Artemisinin-based Combination Therapy (ACT) and other non-compliant health worker behaviour, influence household expenditures during ca [...] depending on ACT availability in their nearest health facility. RESULTS:...
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase-2 genes on the metabolism of artemisinin-based... (Publications)
combination therapies, in different populations are needed to evaluate the influence of pharmacogenetic factors on the clearance of antimalarials [...] netics of antimalarials is poorly known, although its application might be critical to optimize treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the effect of single [...] patients treated with dihydroartemisinin-piperaquine. The frequency of SNPs varied with the enzyme and the population. Higher frequencies of...