Strain diversity and the evolution of antibiotic resistance (Publications)
future of tuberculosis control as well. In this chapter, we review our current understanding of the impact of genetic diversity in the broadest sense on the evolution of drug-resistant members of the M [...] context, genetic diversity can influence the rate and likelihood of resistance emerging; it can also modulate the net physiological impact of resistance and the propensity of an organism to improve any defects [...] Drug resistance is best thought of as an ongoing biological process....
Strain diversity and the evolution of antibiotic resistance (Publications)
future of tuberculosis control as well. In this chapter, we review our current understanding of the impact of genetic diversity in the broadest sense on the evolution of drug-resistant members of the M [...] context, genetic diversity can influence the rate and likelihood of resistance emerging; it can also modulate the net physiological impact of resistance and the propensity of an organism to improve any defects [...] Drug resistance is best thought of as an ongoing biological process....
Economic growth and energy use during different stages of development: an empirical analysis (Publications)
empirically investigates the effect of energy use on economic growth throughout different stages of development. Along with direct effects, energy is allowed to influence income growth indirectly by capital [...] measures aiming at restricting energy consumption should be evaluated against the background of a region's stage of economic development. [...] substantially with regard to the country's income level. For middle-income countries including the quintet of large emerging economies -...
Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines (Publications)
characterization of nine new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinoline derivatives are reported. These belong to a library whose rationale for the design was the previous knowledge of the biological [...] moderately active against Plasmodium falciparum. Of these, 3 and 9 can be considered as lead scaffolds for further optimization. The substituent on BS did not influence the 3D structure properties and the H-1 NMR [...] biological relevant properties of both structural moieties....
Landscape pattern analysis and Bayesian modeling for predicting <em>Oncomelania hupensis</em> distribution in Eryuan County, People's Republic of... (Publications)
Detailed knowledge of how local landscape patterns influence the distribution of Oncomelania hupensis, the intermediate host snail of Schistosoma japonicum, might facilitate more effective schistosomiasis [...] area of Eryuan County, Yunnan Province, People's Republic of China, and developed Bayesian geostatistical models to explore heterogeneities of landscape composition in relation to distribution of O. hupensis [...] However, the distribution of infected snails was not significantly...
A central role for GRB10 in regulation of islet function in man (Publications)
paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism [...] secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and [...] and imprinted in a parent-of-origin fashion in different tissues....
Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines (Publications)
characterization of nine new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinoline derivatives are reported. These belong to a library whose rationale for the design was the previous knowledge of the biological [...] moderately active against Plasmodium falciparum. Of these, 3 and 9 can be considered as lead scaffolds for further optimization. The substituent on BS did not influence the 3D structure properties and the H-1 NMR [...] biological relevant properties of both structural moieties....
A central role for GRB10 in regulation of islet function in man (Publications)
paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism [...] secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and [...] and imprinted in a parent-of-origin fashion in different tissues....
Economic growth and energy use during different stages of development: an empirical analysis (Publications)
empirically investigates the effect of energy use on economic growth throughout different stages of development. Along with direct effects, energy is allowed to influence income growth indirectly by capital [...] measures aiming at restricting energy consumption should be evaluated against the background of a region's stage of economic development. [...] substantially with regard to the country's income level. For middle-income countries including the quintet of large emerging economies -...
Landscape pattern analysis and Bayesian modeling for predicting <em>Oncomelania hupensis</em> distribution in Eryuan County, People's Republic of... (Publications)
Detailed knowledge of how local landscape patterns influence the distribution of Oncomelania hupensis, the intermediate host snail of Schistosoma japonicum, might facilitate more effective schistosomiasis [...] area of Eryuan County, Yunnan Province, People's Republic of China, and developed Bayesian geostatistical models to explore heterogeneities of landscape composition in relation to distribution of O. hupensis [...] However, the distribution of infected snails was not significantly...