Conformational aspects in the design of inhibitors for serine hydroxymethyltransferase (SHMT): biphenyl, aryl sulfonamide, and aryl sulfone motifs (Publications)
resolution. We observed an unprecedented influence of the torsion angle of ortho-substituted biphenyl moieties on cell-based efficacy. The peculiar lipophilic character of the sulfonyl moiety was highlighted [...] Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or [...] sulfone motifs were synthesized and tested towards serine...
'My wife, you are supposed to have a rest now': an analysis of norms influencing men's role in prenatal care in south-eastern Tanzania (Publications)
heads have a direct bearing on women's reproductive health. However, little is known about the influence of changing norms and values on men's role in ensuring women's health during pregnancy and childbirth [...] women's discussions on men's roles and responsibilities in prenatal care and links them to an analysis of norms and values at the household level and beyond. Data from eight focus group discussions with men [...] and women were consensually coded and analysed using a qualitative content...
'My wife, you are supposed to have a rest now': an analysis of norms influencing men's role in prenatal care in south-eastern Tanzania (Publications)
heads have a direct bearing on women's reproductive health. However, little is known about the influence of changing norms and values on men's role in ensuring women's health during pregnancy and childbirth [...] women's discussions on men's roles and responsibilities in prenatal care and links them to an analysis of norms and values at the household level and beyond. Data from eight focus group discussions with men [...] and women were consensually coded and analysed using a qualitative content...
Conformational aspects in the design of inhibitors for serine hydroxymethyltransferase (SHMT): biphenyl, aryl sulfonamide, and aryl sulfone motifs (Publications)
resolution. We observed an unprecedented influence of the torsion angle of ortho-substituted biphenyl moieties on cell-based efficacy. The peculiar lipophilic character of the sulfonyl moiety was highlighted [...] Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or [...] sulfone motifs were synthesized and tested towards serine...
What makes health systems resilient? A qualitative analysis of the perspectives of Swiss NGOs (Publications)
the advent of increasing and intensifying shocks on the health system and its amplified effects due to globalization. Using the example of non-state actors based in Switzerland, the aim of this study is [...] health systems of their partner countries and to reflect on the practical implications of resilience for the multiple actors involved. Consequently, this paper analyses the key attributes of resilience that [...] into the expected role of the governments, the role of the NGOs, and practical...
What makes health systems resilient? A qualitative analysis of the perspectives of Swiss NGOs (Publications)
the advent of increasing and intensifying shocks on the health system and its amplified effects due to globalization. Using the example of non-state actors based in Switzerland, the aim of this study is [...] health systems of their partner countries and to reflect on the practical implications of resilience for the multiple actors involved. Consequently, this paper analyses the key attributes of resilience that [...] into the expected role of the governments, the role of the NGOs, and practical...
Impact of population aging on future temperature-related mortality at different global warming levels (Publications)
projected to increase with global warming, the influence of population aging on these trends remains unclear. Here we show that at 1.5 °C, 2 °C, and 3 °C of global warming, heat-related mortality in 800
Disposition of mefloquine and enpiroline is highly influenced by a chronic <em>Schistosoma mansoni</em> infection (Publications)
destructions of the gut wall and liver and can influence drug disposition. This study aimed to investigate the impact of a chronic S. mansoni infection on pharmacokinetic (PK) parameters of two promising [...] onset of action, hepatic shift and worm burden reductions. Following mefloquine administration hepatic shifting and significant worm burden reductions (79.2%) were observed after 72 h. The majority of worms
Epigenome-wide meta-analysis of methylation in children related to prenatal NO2 air pollution exposure (Publications)
applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure
How can we achieve and maintain high-quality performance of health workers in low-resource settings? (Publications)
for the delivery of health interventions. However, inadequate health-worker performance is a very widespread problem. We present an overview of issues and evidence about the determinants of performance and [...] complex behaviours that have many potential influences. Reviews of intervention studies in low and middle income countries suggest that the simple dissemination of written guidelines is often ineffective, [...] knowledge about the true determinants of performance and about the...