Lipidomics and genomics of <em>Mycobacterium tuberculosis</em> reveal lineage-specific trends in mycolic acid biosynthesis (Publications)
and lineages. MA patterns of "ancient" lineages contrasted those from "modern" lineages, with a lower representation of alpha-mycolates among Lineage 6 strains and an inversion of the methoxy: keto-mycolates [...] abundance in the cell envelope of the Mycobacterium tuberculosis complex (MTBC). MAs form an efficient permeability barrier, modulate host innate immune responses, and are the targets of several anti-tuberculosis [...] sis drugs. Using mass spectrometry, we measured the relative...
Gut microbiota targeted approach in the management of chronic liver diseases (Publications)
portal vein, which enables the gut microbiota and gut-derived products to influence liver health. There is accumulating evidence of decreased gut flora diversity and alcohol sensitivity in patients with various [...] ip between the gut and the liver, and explained the mechanisms of how the gut microbiota ecosystem alteration affects the pathogenesis of chronic liver diseases. We presented gut-microbiota targeted i
A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries (Publications)
There is conflicting evidence on the influence of weather on COVID-19 transmission. Our aim is to estimate weather-dependent signatures in the early phase of the pandemic, while controlling for socio-economic [...] little evidence of meteorological conditions having influenced the early stages of local epidemics and conclude that population behaviour and government interventions are more important drivers of transmission [...] cities in 26 countries, with a decrease of 0.087 (95% CI: 0.025;...
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation (Publications)
present a database of > 270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15-17% of the additive genetic variance of DNAm. We show that [...] Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative [...] that the genetic architecture of DNAm levels is highly polygenic....
Synthesis of bicyclic amines and their activities against <em>Trypanosoma brucei rhodesiense</em> and <em>Plasmodium falciparum</em> K1 (Publications)
antiprotozoal 4-dialkylaminobicyclo[2.2.2]octan-2-imines to investigate the influence of several functional groups in position 2 of the ring skeleton on the antitrypanosomal and antiplasmodial activities. [...] compared to their parent oximes and to formerly synthesized 4-amino-2-azabicyclo[3.2.2]nonanes. Some of the 4-aminobicyclo[2.2.2]oct-2-ylamines exhibit moderate in vivo activity in mice against Trypanosoma
Non-stationary partition modeling of geostatistical data for malaria risk mapping (Publications)
modeling of malaria is stationarity, that is spatial correlation is a function of the separation vector between locations. However, local factors (environmental or human-related activities) may influence ge [...] non-stationarity. Ignoring this characteristic in malaria spatial modeling may lead to inaccurate estimates of the standard errors for both the covariate effects and the predictions. In this paper, a model based [...] within each tile and between-tile correlation was taken into account....
Gut microbiota targeted approach in the management of chronic liver diseases (Publications)
portal vein, which enables the gut microbiota and gut-derived products to influence liver health. There is accumulating evidence of decreased gut flora diversity and alcohol sensitivity in patients with various [...] ip between the gut and the liver, and explained the mechanisms of how the gut microbiota ecosystem alteration affects the pathogenesis of chronic liver diseases. We presented gut-microbiota targeted i
A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries (Publications)
There is conflicting evidence on the influence of weather on COVID-19 transmission. Our aim is to estimate weather-dependent signatures in the early phase of the pandemic, while controlling for socio-economic [...] little evidence of meteorological conditions having influenced the early stages of local epidemics and conclude that population behaviour and government interventions are more important drivers of transmission [...] cities in 26 countries, with a decrease of 0.087 (95% CI: 0.025;...
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation (Publications)
present a database of > 270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15-17% of the additive genetic variance of DNAm. We show that [...] Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative [...] that the genetic architecture of DNAm levels is highly polygenic....
Synthesis of bicyclic amines and their activities against <em>Trypanosoma brucei rhodesiense</em> and <em>Plasmodium falciparum</em> K1 (Publications)
antiprotozoal 4-dialkylaminobicyclo[2.2.2]octan-2-imines to investigate the influence of several functional groups in position 2 of the ring skeleton on the antitrypanosomal and antiplasmodial activities. [...] compared to their parent oximes and to formerly synthesized 4-amino-2-azabicyclo[3.2.2]nonanes. Some of the 4-aminobicyclo[2.2.2]oct-2-ylamines exhibit moderate in vivo activity in mice against Trypanosoma