The interspecific competition between larvae of <em>Aedes aegypti</em> and major african malaria vectors in a semi-field system in Tanzania (Publications)
potentially reducing disease transmission. It also influences population dynamics, and cannibalistic and predatory behaviors. However, knowledge of interspecific competition between Ae. aegypti and Anopheles [...] involved density combinations of 100:100, 200:0, and 0:200 (Ae. aegypti: Anopheles), reared with and without food, in small habitats (8.5 cm height × 15 cm diameter) with 0.5 liters of water and large habitats [...] compared to Ae. aegypti. The mean wing lengths of all species were...
Click coupling of flavylium dyes with plasmodione analogues: towards new redox-sensitive pro-fluorophores (Publications)
and electrochemical properties of these probes were evaluated, focusing on their fluorogenic responses. The influence of both the redox status of the quinone and the length of the PEG chain separating the [...] development of redox-sensitive molecular fluorescent probes for the detection of redox changes in Plasmodium falciparum-parasitized red blood cells remains of interest due to the limitations of current g [...] screening and synthesis of new pro-fluorophores based on flavylium azido dyes...
Resurgence of HIV infection among men who have sex with men in Switzerland: mathematical modelling study (Publications)
(cART). The objectives of this mathematical modelling study were: to describe the dynamics of the HIV epidemic in MSM in Switzerland using national data; to explore the effects of hypothetical prevention [...] observed data well. By the end of 2010, an estimated 13.5% (95% CI 12.5, 14.6%) of all HIV-infected MSM were undiagnosed and accounted for 81.8% (95% CI 81.1, 82.4%) of new HIV infections. The transmission [...] greatest influence on estimates of the net transmission...
Resurgence of HIV infection among men who have sex with men in Switzerland: mathematical modelling study (Publications)
(cART). The objectives of this mathematical modelling study were: to describe the dynamics of the HIV epidemic in MSM in Switzerland using national data; to explore the effects of hypothetical prevention [...] observed data well. By the end of 2010, an estimated 13.5% (95% CI 12.5, 14.6%) of all HIV-infected MSM were undiagnosed and accounted for 81.8% (95% CI 81.1, 82.4%) of new HIV infections. The transmission [...] greatest influence on estimates of the net transmission...
The Evolution and Ecology of Drug-Resistant MTBC (Page)
https://www.swisstph.ch/de/about/mpi/tuberculosis-ecology-and-evolution/the-evolution-and-ecology-of-drug-resistant-mtbc
Evolution and Ecology of Drug-resistant MTBC Fitness Effect of Drug Resistance We use a combination of experimental evolution, molecular epidemiology, comparative genome sequencing of clinical strains and [...] in the relative abundance of each mutation in the clinic. Compensation and Other Epistatic Interactions In recent years, it has become clear that the molecular mechanisms of resistance to antibiotics are [...] mutations and the strain genetic background influence the fitness of...
Effects of smoking bans on passive smoking exposure at work and at home. The European Community Respiratory Health Survey (Publications)
ECHRS wave, the odds of passive smoking at work was markedly reduced after global smoking bans (OR=0.45, 95%CI 0.25-0.81), particularly among non-smokers, while the protective effect of global smoking bans [...] This longitudinal study investigated whether smoking bans influence passive smoking at work and/or at home in the same subjects. Passive smoking at work and/or at home was investigated in random population [...] workplaces were effective in reducing passive smoking at work in Europe....
Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission (Publications)
almost 90% of urban population growth will occur in regions predicted to be most burdened by the AMR crisis, there is an urgent need to build effective, evidence-based policies that could influence massive [...] burden lower- and middle-income countries (LMICs) in the coming decades. Although the contributions of human and veterinary antibiotic misuse to this crisis are well-recognized, environmental transmission [...] or food contaminated with human and animal faeces) has been given less...
Quantitative structure: antiprotozoal activity relationships of sesquiterpene lactones (Publications)
properties. The observed variance in the biological data can be explained in terms of subtle variations in the relative influences of various molecular descriptors [...] Prompted by results of our previous studies where we found high activity of some sesquiterpene lactones (STLs) against Trypanosoma brucei rhodesiense (which causes East African sleeping sickness), we have [...] set of 40 STLs against T. brucei rhodesiense, T. cruzi, Leishmania donovani and Plasmodium falciparum. Furthermore,...
Mapping and prediction of schistosomiasis in Nigeria using compiled survey data and Bayesian geospatial modelling (Publications)
database for the generation of point prevalence maps. This exercise revealed that the disease is endemic in 35 of the country's 36 states, including the federal capital territory of Abuja, and found in 462 [...] The estimated prevalence of S. haematobium, based on Bayesian geospatial predictive modelling with a set of bioclimatic variables, ranged from 0.2% to 75% with a mean prevalence of 23% for the country as [...] 462 unique locations out of 833 different survey locations. Schistosoma...
Prediction of MS disability by multimodal evoked potentials: investigation during relapse or in the relapse-free interval? (Publications)
known about optimal timing of multimodal evoked potential (EP)-investigations regarding prediction of MS disability. The aim of this study was to investigate whether timing of EP-investigations during a [...] remnants of relapses are a better predictor for development of medium-term disability than is the extent of impulse propagation impairment measured during relapse. SIGNIFICANCE: This suggests a role of multimodal [...] a relapse or in the relapse-free interval influences prediction of MS...