Quantitative structure: antiprotozoal activity relationships of sesquiterpene lactones (Publications)
properties. The observed variance in the biological data can be explained in terms of subtle variations in the relative influences of various molecular descriptors [...] Prompted by results of our previous studies where we found high activity of some sesquiterpene lactones (STLs) against Trypanosoma brucei rhodesiense (which causes East African sleeping sickness), we have [...] set of 40 STLs against T. brucei rhodesiense, T. cruzi, Leishmania donovani and Plasmodium falciparum. Furthermore,...
Factors influencing the work efficiency of district health managers in low-resource settings: a qualitative study in Ghana (Publications)
timely release of district funds. CONCLUSIONS: Filling District Health Management Team vacancies, developing leadership and management skills of district health managers, ensuring a better flow of district funds [...] management practices have detrimental effects. The aim of the present study was to identify factors contributing to inefficient management practices of district health managers and ways to improve their overall [...] were conducted with district health managers in three districts o...
Mapping and prediction of schistosomiasis in Nigeria using compiled survey data and Bayesian geospatial modelling (Publications)
database for the generation of point prevalence maps. This exercise revealed that the disease is endemic in 35 of the country's 36 states, including the federal capital territory of Abuja, and found in 462 [...] The estimated prevalence of S. haematobium, based on Bayesian geospatial predictive modelling with a set of bioclimatic variables, ranged from 0.2% to 75% with a mean prevalence of 23% for the country as [...] 462 unique locations out of 833 different survey locations. Schistosoma...
Beijing sublineages of <em>Mycobacterium tuberculosis</em> differ in pathogenicity in the Guinea pig (Publications)
e from four of the five sublineages of lineage 2 in the guinea pig model and subjected these strains to comparative whole-genome sequencing. The results of these studies showed that all of the clinical [...] Beijing family of Mycobacterium tuberculosis strains is part of lineage 2 (also known as the East Asian lineage). In clinical studies, we have observed that isolates from the sublineage RD207 of lineage 2 were [...] strains were capable of growing and causing lung pathology in guinea pigs...
Effects of smoking bans on passive smoking exposure at work and at home. The European Community Respiratory Health Survey (Publications)
ECHRS wave, the odds of passive smoking at work was markedly reduced after global smoking bans (OR=0.45, 95%CI 0.25-0.81), particularly among non-smokers, while the protective effect of global smoking bans [...] This longitudinal study investigated whether smoking bans influence passive smoking at work and/or at home in the same subjects. Passive smoking at work and/or at home was investigated in random population [...] workplaces were effective in reducing passive smoking at work in Europe....
Effective coverage in health systems: evolution of a concept (Publications)
and evolution of the concept of effective coverage metrics to illuminate potential improvements in coherence, terminology, application, and visualizations, based on which a combination of approaches appears [...] hypertension. Nevertheless, despite decades of application of effective coverage concepts, there is considerable variability in the terminology used and the choices of effectiveness decay steps included in the [...] need is a critical dimension of health system performance. Intervention...
Heart rate and salivary cortisol as indicators of arousal and synchrony in clients, therapy horses and therapist in equine-assisted therapy (Publications)
mastering a challenge. Future research should investigate this potential benefit of EAT, considering the reciprocal influences and the relationship between client, therapist and horse. [...] observed between therapy sessions with or without a therapy horse, except during the challenge phase of the EAT protocol, where clients had a significantly lower HR when interacting with the therapy horse [...] relationship intensity is an important factor for the synchronization process. Moreover, the...
Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission (Publications)
almost 90% of urban population growth will occur in regions predicted to be most burdened by the AMR crisis, there is an urgent need to build effective, evidence-based policies that could influence massive [...] burden lower- and middle-income countries (LMICs) in the coming decades. Although the contributions of human and veterinary antibiotic misuse to this crisis are well-recognized, environmental transmission [...] or food contaminated with human and animal faeces) has been given less...
Social and cultural determinants of oral cholera vaccine uptake in Zanzibar (Publications)
examined the influence of local community views of cholera on oral cholera vaccine (OCV) uptake in a mass vaccination campaign in 2009 in peri-urban and rural areas of Zanzibar. It used data from interviews [...] determinants of anticipated OCV acceptance. OCV uptake was lower than the reported anticipated acceptance. Less than half of the 356 adult respondents (49.7%) drank the required two doses of OCV. Variables [...] l features of diarrheal illness that respondents identified with a cholera...
Comparative testing of a miniature diffusion size classifier to assess airbone ultrafine particles under field conditions (Publications)
the development of cardiovascular and pulmonary diseases; thus, detection and quantification of these particles are important for evaluating their potential health hazards. As part of the UFP exposure [...] a highway. Measurements with miniDiSC and P-TRAK correlated well (correlation of r = 0.84) but average particle numbers of the miniDiSC were 30%âeuro"60% higher. This difference was significantly increased [...] dependent effect led to very similar results across all counters.We did not...
