Association of long-term exposure to traffic-related PM10 with heart rate variability and heart rate dynamics in healthy subjects (Publications)
cal evidence on the influence of long-term exposure to traffic-related particulate matter (TPM10) on heart rate variability (HRV) is weak. OBJECTIVE: To evaluate the association of long-term exposure (10years) [...] appeared to be more susceptible to the effects of TPM10. CONCLUSION: This study suggests that long-term exposure to TPM10 triggers adverse changes in the regulation of the cardiovascular system. These adverse [...] (10years) with TPM10 on the regulation of the autonomic...
Effects of self-esteem and stress on self-assessed health: a Swiss study from adolescence to early adulthood (Publications)
PURPOSE: A large literature shows important effects of self-esteem and stress on mental and physical health in young adulthood. Negative life events are one type of stressor associated with poor health, but it [...] Education to Employment" (TREE) panel study, a nationally representative longitudinal survey of a cohort of Swiss young adults, using logistic regression analysis. The study includes eight waves over a [...] to their known influence on mental health, stress and self-esteem are...
The role of paternity acknowledgment in breastfeeding noninitiation (Publications)
States, less than a quarter of mothers breastfeed in accordance with national recommendations. To date, researchers have demonstrated that paternal support directly influences breastfeeding outcomes; however [...] adjusting for confounders, mothers who were not married but the paternity of the infant was acknowledged had 50% higher odds of breastfeeding noninitiation compared with mothers who were married and their [...] however, healthcare practitioners may not be able to quantify a lack of...
Safety and immunogenicity of tetanus/diphtheria vaccination in patients with rheumatic diseases - a prospective multi-centre cohort study (Publications)
SpA/PsA, 39 vasculitis) and 253 HCs. Of the patients, 89% were on immunosuppressive/immunomodulatory medication. Three months post-vaccination 100% of HCs vs 98% of patients were protected against tetanus [...] aimed to assess the safety and immunogenicity of a diphtheria/tetanus vaccine booster dose in three different patient groups with rheumatic diseases on a variety of immunosuppressive/immunomodulatory medications [...] factor negatively influencing tetanus immunogenicity, whereas only MTX...
<em>Staphylococcus aureus</em> in nasal lavage and biopsy of patients with chronic rhinosinusitis (Publications)
frequency of S. aureus and SASCV in CRS patients and S. aureus-related effects on the local immune response should be prospectively investigated. METHODS: Nasal lavages and mucosal biopsies of CRS patients [...] positivity did not influence biomarker concentrations in nasal lavages. Genes for T(H2) cytokines were not differentially transcribed. CONCLUSIONS: We could not observe a higher prevalence of S. aureus in CRS [...] suitable for detecting SASCV, real time PCR and fluorescence in situ...
The number of comorbidities as an important cofactor to ASA class in predicting postoperative outcome: an international multicentre cohort study (Publications)
considered. Thus, the aim of this study was to quantify the burden of comorbidities in perioperative patients and to assess, independent of ASA class, its potential influence on perioperative outcome. [...] quantify the high prevalence of multimorbidity in the surgical population and show that the number of comorbidities is predictive of negative postoperative outcomes, independent of ASA class. [...] study were of all ages, undergoing any type of in-hospital surgery and were followed up until...
Road traffic noise, blood pressure and heart rate: pooled analyses of harmonized data from 88,336 participants (Publications)
increase blood pressure and heart rate. It is unclear to what extent exposure to air pollution may influence this relationship. We investigated associations between noise, blood pressure and heart rate, with [...] pressure and heart rate were obtained by trained clinical professionals. Pooled cross-sectional analyses of harmonized data were conducted at the individual level and with random-effects meta-analyses. RESULTS: [...] associated with a 0.93 (95% CI 0.76;1.11) bpm increase in heart rate,...
Clinical markers of asthma and IgE assessed in parents before conception predicts asthma and hay fever in the offspring (Publications)
However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans. OBJECTIVE: We aimed to assess the associations of parental asthma severity [...] 13, 4.45] and 1.83[1.45, 2.31], respectively). This was confirmed in a sensitivity analysis of a subgroup of offspring aged 11-22 years with information on parental disease activity both before and after [...] 1991-1993, and data on 9100 offspring born 1972-2012. Adjusted relative risk...
The early development of wheeze: environmental determinants and genetic susceptibility at 17q21 (Publications)
environmental determinants of infections and wheeze in the 1st year of life, potential modifications of these associations by 17q21, and the implications for different trajectories of wheeze. Methods We followed [...] followed 983 children in rural areas of Europe from birth until age 6. Symptoms of wheeze, rhinitis, fever, and environmental exposures were documented with weekly diaries during year 1. Asthma at age 6 [...] Measurements and Main Results Early wheeze was positively associated with...
Pharmacokinetics of a pediatric tribendimidine dose-finding study to treat hookworm infection in African children (Publications)
and ratios of dADT to adADT. We did not detect an influence of Cmax or AUC0-22h of dADT or adADT on drug efficacy or adverse events. Since our study population was bearing hookworm infection of mainly low [...] (Cmax) and area under the blood concentration-time curve (AUC0-22h) as predictors of drug efficacy. Dried blood spot samples of 101 children were analyzed. We observed a less than proportional and proportional [...] children, the main target group for treatment programs, have not been...