Pharmacokinetics of a pediatric tribendimidine dose-finding study to treat hookworm infection in African children (Publications)
and ratios of dADT to adADT. We did not detect an influence of Cmax or AUC0-22h of dADT or adADT on drug efficacy or adverse events. Since our study population was bearing hookworm infection of mainly low [...] (Cmax) and area under the blood concentration-time curve (AUC0-22h) as predictors of drug efficacy. Dried blood spot samples of 101 children were analyzed. We observed a less than proportional and proportional [...] children, the main target group for treatment programs, have not been...
<em>Staphylococcus aureus</em> in nasal lavage and biopsy of patients with chronic rhinosinusitis (Publications)
frequency of S. aureus and SASCV in CRS patients and S. aureus-related effects on the local immune response should be prospectively investigated. METHODS: Nasal lavages and mucosal biopsies of CRS patients [...] positivity did not influence biomarker concentrations in nasal lavages. Genes for T(H2) cytokines were not differentially transcribed. CONCLUSIONS: We could not observe a higher prevalence of S. aureus in CRS [...] suitable for detecting SASCV, real time PCR and fluorescence in situ...
Supervising community health workers in low-income countries: a review of impact and implementation issues (Publications)
gray literature. RESULTS: A total of 22 impact papers were identified. Papers were from a range of low- and middle-income countries addressing the supervision of a variety of health care providers. We classified [...] Community health workers (CHWs) are an increasingly important component of health systems and programs. Despite the recognized role of supervision in ensuring CHWs are effective, supervision is often weak [...] adequate supervision and how different supervision strategies influence...
Estimating prevalence and infection intensity of soil-transmitted helminths using quantitative polymerase chain reaction and kato-katz in school-age... (Publications)
may influence qPCR performance. We estimated STH prevalence and infection intensity by using qPCR in schoolchildren from Huambo, Uige, and Zaire, Angola, and compared its performance with that of the Kato-Katz [...] qPCR and Kato-Katz. DNA extraction and qPCR were repeated on 191 (of 278) samples that were initially qPCR negative but Kato-Katz positive, of which 112 (58.6%) became positive. Similar prevalence for Ascaris [...] Stool samples from 3,063 children (219 schools) were preserved in 96%...
Socioeconomic, cultural and behavioural features of prior and anticipated influenza vaccine uptake in urban and rural Pune district, India: a... (Publications)
committees of the Maharashtra Association of Anthropological Sciences and the WHO, and by the Ethics Commission of Basel, Switzerland. The proposed research will provide a better understanding of communication [...] major determinant of vaccine effectiveness, and the social, cultural and economic determinants of population acceptance require study for effective policy and action. Pune is a focus of pandemic influenza [...] the socioeconomic, cultural and behavioural determinants of anticipated...
Genetic similarity of hepatitis C virus and fibrosis progression in chronic and recurrent infection after liver transplantation (Publications)
The effect of hepatitis C virus (HCV) genetic heterogeneity on clinical features of post-transplantation hepatitis C is controversial. Different regions of the HCV genome have been associated with apoptosis [...] al severity of recurrent hepatitis C. We have compared nucleotide sequences of HCV Core, NS3 and NS5b regions in HCV-1b-infected patients 3 years post-transplantation (n = 22). A cohort of nontransplanted [...] nted patients (n = 22) was used as control of natural chronic HCV-1b...
Parental attitudes towards measles vaccination in the canton of Aargau, Switzerland: a latent class analysis (Publications)
patterns of attitudes towards or against measles vaccination through Latent Class Analysis (LCA) in a sub-sample of mothers living in the canton of Aargau in Switzerland. METHODS: Parents of young children [...] Despite the successes of routine national childhood vaccination programmes, measles remains a public health concern. The purpose of this paper is to investigate how patterns of parental attitudes are [...] identify groups of parents showing distinct patterns of attitudes and beliefs...
The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study (Publications)
may impact subsequent lung function and allergic disease risk. OBJECTIVES: To investigate the influence of childhood living environment and biodiversity indicators on atopy, asthma and lung function in [...] CONCLUSIONS: This is the first study to report beneficial effects of growing up on a farm on adult FEV1. Our study confirmed the beneficial effects of early farm life on sensitisation, asthma and rhinitis, and [...] approximately 10 201 participants aged 26-54 years from 14 countries,...
Caregiving can be costly: a qualitative study of barriers and facilitators to conducting kangaroo mother care in a US tertiary hospital neonatal... (Publications)
Massachusetts. A series of open-ended interview questions were designed to elicit all aspects of mothers' experiences and to understand how these experiences influence provision of KMC. All interviews were [...] investment of time and resources. This study sought to understand barriers and facilitators to provision of KMC in the NICU. METHODS: We conducted semi-structured in-depth interviews with mothers of preterm [...] transportation, lack of child care, and inadequate maternity leave policies...
Large-scale determinants of intestinal schistosomiasis and intermediate host snail distribution across Africa: does climate matter? (Publications)
determinants of the distribution of the African S. mansoni-Biomphalaria system and potential impacts of climatic changes. Snail species distribution models included several combinations of climatic and [...] warming will cause an expansion of the areas potentially suitable for infectious disease transmission. However, the transmission of infectious diseases is governed by a myriad of ecological, economic, evolutionary [...] habitat variables to measure anthropogenic influence. The predictive...