The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant <em>Plasmodium falciparum</em> (Publications)
y quantify which of these factors drive establishment and spread of drug resistance. Drug resistance was more likely to evolve in low transmission settings due to the lower levels of (i) immunity and (ii) [...] n between genotypes. Spread of parasites resistant to artemisinin partner drugs depended on the period of low drug concentration (known as the selection window). Spread of partial artemisinin resistance [...] The effectiveness of artemisinin-based combination therapies (ACTs) to treat...
Influence of testing modality on bioefficacy for the evaluation of Interceptor® G2 mosquito nets to combat malaria mosquitoes in Tanzania (Publications)
impact of bioassay modality, mosquito exposures of the alphacypermethrin ITN Interceptor((R)) and dual adulticide Interceptor((R)) G2 were investigated. METHODS: This study evaluated the performance of In [...] )) G2 compared to Interceptor((R)) against local strains of mosquitoes in Tanzania. Unwashed and 20x times washed nets were tested. Efficacy of ITNs was measured by four bioassay types: (1) World Health [...] resistant strains, superiority of Interceptor((R)) G2 over Interceptor((R)) was...
Influence of exposure assessment methods on associations between long-term exposure to outdoor fine particulate matter and risk of cancer in the... (Publications)
consistent, possibly because of the diversity of methods used to assess exposure. OBJECTIVES: To investigate how using different PM2.5 exposure assessment methods influences risk estimates in the large [...] associations for all-sites cancer (3711 cases), with a first slope of HRs of 1.53 (1.24-1.88) and 1.43 (1.19-1.73) for one IQR increase of cumulative PM2.5 exposure for the LUR and the Gazel-Air models r [...] series > /=20-years annual concentrations. Spearman correlation coefficient...
The influence of roads on the fine-scale population genetic structure of the dengue vector <em>Aedes aegypti</em> (Linnaeus) (Publications)
roads that can act as a barrier. Roads can influence the population genetic structure of Ae. aegypti. We investigated the genetic structure and gene flow of Ae. aegypti as influenced by a primary road [...] barrier effect of the road. A total of 359 adults and 17 larvae Ae. aegypti were collected from June to September 2017 in 13 sites across EB. North (N1-N8) and South (S1-S5) comprised of 211 and 165 individuals
Diagnosis of soil-transmitted helminths using the Kato-Katz technique: what is the influence of stirring, storage time and storage temperature on... (Publications)
egg counts of A. lumbricoides and T. trichiura remained stable over time regardless of storage temperature of whole stool samples. Finally, we found a significant reduction of the variation of hookworm and [...] study aimed to study the effect of storage time, storage temperature and stirring of stool samples on fecal egg counts (FECs). METHODOLOGY/PRINCIPAL FINDINGS: In the framework of a clinical trial on Pemba Island [...] dropped close to zero, irrespective of the storage condition. Whole...