<em>IL-33</em> polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort (Publications)
between IL-33 polymorphisms during development of childhood atopic diseases and underlying mechanisms including immune regulation of Tregs. METHODS: Genotyping of IL-33-polymorphisms (rs928413, rs1342326) was [...] BACKGROUND: IL-33 polymorphisms influence the susceptibility to asthma. IL-33 indirectly induces Th2-immune responses via dendritic cell activation, being important for development of atopic diseases. Furthermore [...] in 880 out of 1133 PASTURE/EFRAIM children. In 4.5 years old...
Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria... (Publications)
the rapid improvement of a child's condition after RAS administration may influence a caregiver's decision to follow this recommendation. Currently, the evidence on the effect of RAS on referral completion [...] limited. METHODS: An observational study accompanied the roll-out of RAS in three malaria endemic settings in the Democratic Republic of the Congo (DRC), Nigeria and Uganda. Community health workers and [...] pre-roll-out phase (aOR=1.81, 95% CI 1.17 to 2.79). CONCLUSIONS: The findings o...
Factors associated with health-related quality of life among home-dwelling older adults aged 75 or older in Switzerland: a cross-sectional study (Publications)
indicator of individuals' perception of their overall health, including social and environmental aspects. As a multidimensional concept, HRQoL can be influenced by a multitude of factors. Studies of HRQoL [...] provide a better understanding of the construct and the role of the environment on how they perceive their HRQoL. Thus, we aimed to assess the HRQoL and investigate the correlates of HRQOL among home-dwelling [...] factors beyond the individual level that impact the HRQoL of home-dwelling...
Legionnaires' disease: a qualitative study on Swiss physicians' approaches to the diagnosis and treatment of community-acquired pneumonia (Publications)
BACKGROUND: The number of reported cases of Legionnaires' disease has increased significantly over the last decade in Switzerland and abroad. Along with the number of cases, the volume of testing has increased [...] lower levels of awareness, reflecting the fact that they treat pneumonia cases empirically without identification of the causative agent, in accordance with current guidelines. The value of the diagnostic [...] been partially attributed to a change in awareness of the disease. Yet,...
The promotion and development of One Health at Swiss TPH and its greater potential (Publications)
thinking. The history of ideas and processes leading to the development of One Health research at the Swiss TPH were inspired by far-sighted and open ideas of the directors and heads of departments, without [...] mentions of One Health in the biomedical literature. Here, we summarise the history of ideas and processes that led to the development of One Health research and development at the Swiss TPH, clarify its [...] becoming part of reporting under the International Health Legislation (IHR...
Social-political and vaccine related determinants of COVID-19 vaccine hesitancy in Tanzania: a qualitative inquiry (Publications)
possessed a range of questions regarding COVID-19 vaccines that they wanted answered by the government. Social factors included preference for traditional and home remedies and influence from others. Political [...] and doubts about the existence of COVID-19 and the vaccine. Our findings suggest that the COVID-19 vaccine is beyond a medical intervention, it carries with it a variety of expectations and myths that need [...] doubts, and concerns over safety issues. An understanding of...
First insights into the phylogenetic diversity of <em>Mycobacterium tuberculosis</em> in Nepal (Publications)
Nepal. Strain variation in Mycobacterium tuberculosis may influence the outcome of TB infection and disease. To date, the phylogenetic diversity of M. tuberculosis in Nepal is unknown. METHODS AND FINDINGS: [...] evidence for an association of Lineage 2 with age or BCG vaccination status. CONCLUSIONS: We found a large genetic diversity of M. tuberculosis in Nepal with representation of all four major lineages. Lineages [...] (SNP) typing and spoligotyping. Drug resistance was determined by...
Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with <em>Fasciola hepatica</em> (Publications)
half-lives (t(1/2)) of artesunate and DHA were considerably altered in infected rats following oral and iv administration of artesunate. CONCLUSIONS: F. hepatica infections strongly influence the disposition [...] vein and blood samples were withdrawn at selected timepoints following 10 mg/kg of iv and a single 100 mg/kg oral dose of artesunate. Plasma was analysed for artesunate and DHA by liquid chromatography [...] infections revealed considerable changes in PK parameters of artesunate and...
Epidemiology of <em>Schistosoma japonicum</em> in China: morbidity and strategies for control in the Dongting Lake region (Publications)
Dongting Lake, covering a very large surface water area of 2691km(2), is located in Hunan Province in the southern part of the People's Republic of China. It is the second-largest freshwater lake in China [...] that the construction of the Three Gorges Super Dam, the largest engineering project ever undertaken, will substantially extend the range of the snail habitats and increase the number of new schistosomiasis [...] China and plays an important role in regulating the amount of water in the...
<em>IL-33</em> polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort (Publications)
between IL-33 polymorphisms during development of childhood atopic diseases and underlying mechanisms including immune regulation of Tregs. METHODS: Genotyping of IL-33-polymorphisms (rs928413, rs1342326) was [...] BACKGROUND: IL-33 polymorphisms influence the susceptibility to asthma. IL-33 indirectly induces Th2-immune responses via dendritic cell activation, being important for development of atopic diseases. Furthermore [...] in 880 out of 1133 PASTURE/EFRAIM children. In 4.5 years old...