Coping with emerging public health problems (Page)
https://www.swisstph.ch/de/impact-stories/coping-with-emerging-public-health-problems
Around a quarter of the population in Switzerland suffers from chronic diseases. These are some of the most frequent causes of death and cause physical and mental stress as well as high healthcare costs [...] health impacts of air pollution, heatwaves, traffic noise or other harmful chemicals. In addition, biobanks are also the bedrock of medical progress in the early detection and diagnosis of chronic diseases [...] . Why is investment in the prevention of chronic diseases such a crucial issue?...
How does the knowledge environment shape procurement practices for orthopaedic medical devices in Mexico? (Publications)
related perspective (i) to analyse factors of managing knowledge of clinical procedures, (ii) to assess the role of this knowledge and in relation to procurement of orthopaedic medical devices, and (iii) to [...] insufficiently developed. CONCLUSIONS: The content of this manuscript is novel as it analyses knowledge-related factors that influence procurement of orthopaedic medical devices in Mexico. Based on our [...] RESULTS: The results of this study are primarily relevant for Mexico but may...
How does the knowledge environment shape procurement practices for orthopaedic medical devices in Mexico? (Publications)
related perspective (i) to analyse factors of managing knowledge of clinical procedures, (ii) to assess the role of this knowledge and in relation to procurement of orthopaedic medical devices, and (iii) to [...] insufficiently developed. CONCLUSIONS: The content of this manuscript is novel as it analyses knowledge-related factors that influence procurement of orthopaedic medical devices in Mexico. Based on our [...] RESULTS: The results of this study are primarily relevant for Mexico but may...
In Ivorian school-age children, infection with hookworm does not reduce dietary iron absorption or systemic iron utilization, whereas afebrile... (Publications)
treatment, respectively. Treatment of afebrile malaria reduced inflammation (P < 0.001) and serum hepcidin (P = 0.004) and improved iron absorption (P = 0.003). Treatment of hookworm infection neither affected [...] BACKGROUND: In sub-Saharan Africa, parasitic diseases and low bioavailable iron intake are major causes of anemia. Anemia results from inflammation, preventing iron recycling and decreasing dietary iron absorption [...] absorption. Hookworm, Plasmodium, and Schistosoma infections...
In Ivorian school-age children, infection with hookworm does not reduce dietary iron absorption or systemic iron utilization, whereas afebrile... (Publications)
treatment, respectively. Treatment of afebrile malaria reduced inflammation (P < 0.001) and serum hepcidin (P = 0.004) and improved iron absorption (P = 0.003). Treatment of hookworm infection neither affected [...] BACKGROUND: In sub-Saharan Africa, parasitic diseases and low bioavailable iron intake are major causes of anemia. Anemia results from inflammation, preventing iron recycling and decreasing dietary iron absorption [...] absorption. Hookworm, Plasmodium, and Schistosoma infections...
Tetrahydropyridinylidene ammonium salts with arylalkyl and diarylalkyl substitution and their antiprotozoal activity (Publications)
ions < 0.06 mu M. A series of compounds was active against Plasmodium falciparum NF54 in low nanomolar concentration and exhibited outstanding selectivity. The influence of substitution pattern and chain [...] benzyl and dibenzyl substitution showed good antiprotozoal activity. This paper reports the synthesis of analogues with longer side chains. They were investigated for their antiprotozoal activities as well
Improving translational power in antischistosomal drug discovery (Publications)
set-up across research groups and their potential influence on experimental results. We explore the pharmacokinetic/pharmacodynamic relationship of selected drug candidates, showcasing opportunities to [...] poverty-associated tropical disease caused by blood dwelling trematodes that threaten approximately 10% of the world population. Praziquantel, the sole drug currently available for treatment, is insufficient [...] the disease and the clinical drug development pipeline is empty. Here, we...
Improving translational power in antischistosomal drug discovery (Publications)
set-up across research groups and their potential influence on experimental results. We explore the pharmacokinetic/pharmacodynamic relationship of selected drug candidates, showcasing opportunities to [...] poverty-associated tropical disease caused by blood dwelling trematodes that threaten approximately 10% of the world population. Praziquantel, the sole drug currently available for treatment, is insufficient [...] the disease and the clinical drug development pipeline is empty. Here, we...
Tetrahydropyridinylidene ammonium salts with arylalkyl and diarylalkyl substitution and their antiprotozoal activity (Publications)
ions < 0.06 mu M. A series of compounds was active against Plasmodium falciparum NF54 in low nanomolar concentration and exhibited outstanding selectivity. The influence of substitution pattern and chain [...] benzyl and dibenzyl substitution showed good antiprotozoal activity. This paper reports the synthesis of analogues with longer side chains. They were investigated for their antiprotozoal activities as well
<em>Mycobacterium tuberculosis</em> lineage 4 comprises globally distributed and geographically restricted sublineages (Publications)
specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage [...] common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration. [...] Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all...