<em>Mycobacterium tuberculosis</em> lineage 4 comprises globally distributed and geographically restricted sublineages (Publications)
specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage [...] common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration. [...] Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all...
Old and new selective pressures on <em>Mycobacterium tuberculosis</em> (Publications)
populations. Some of the most important drivers of MTBC evolution have been the host immune response and human demography. These old selective forces have shaped many of the features of human TB we see today [...] the use of anti-TB drugs. Here we discuss how the emergence of HIV/TB and drug resistance could impact the long-term balance between MTBC and its human host, and how these changes might influence the future [...] future evolutionary trajectory of MTBC
Old and new selective pressures on <em>Mycobacterium tuberculosis</em> (Publications)
populations. Some of the most important drivers of MTBC evolution have been the host immune response and human demography. These old selective forces have shaped many of the features of human TB we see today [...] the use of anti-TB drugs. Here we discuss how the emergence of HIV/TB and drug resistance could impact the long-term balance between MTBC and its human host, and how these changes might influence the future [...] future evolutionary trajectory of MTBC
A role for systems epidemiology in tuberculosis research (Publications)
been slow, and remains burdened by important gaps in our knowledge of the basic biology of Mycobacterium tuberculosis, the causative agent of TB, and its interaction with the human host. Fortunately, major [...] that will help fill some of these gaps. However, to fully comprehend TB and control this disease globally, current systems biological approaches will not suffice. The influence of host and pathogen diversity
A role for systems epidemiology in tuberculosis research (Publications)
been slow, and remains burdened by important gaps in our knowledge of the basic biology of Mycobacterium tuberculosis, the causative agent of TB, and its interaction with the human host. Fortunately, major [...] that will help fill some of these gaps. However, to fully comprehend TB and control this disease globally, current systems biological approaches will not suffice. The influence of host and pathogen diversity
Eating disorders and disordered eating in different cultures (Publications)
differentiation of eating disorders as independent categories of mental disorder. Shorter's historical analysis, however, suggests that it may be useful to reconsider the relationship of AN and BN to the [...] on the effect of Western esthetics rather than the sociology of health care institutions, and has important implications for policy and publicity about eating disorders, the question of how culture and [...] the broader class of somatoform disorders. Also, by conferring legitimacy on this...
New 2‑aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities (Publications)
formation of guanidines with suitable amines. The prepared compounds differ from each other by the substitutions of their amino group and of their phenyl ring. The 2-aminopyrimidines were tested by use of microplate [...] cells (rat skeletal myoblasts). Some of the compounds exhibited quite good antitrypanosomal activity, and others showed excellent antiplasmodial activity. The influence of the structural modifications on these [...] their in vitro activities against a causative organism of...
Eating disorders and disordered eating in different cultures (Publications)
differentiation of eating disorders as independent categories of mental disorder. Shorter's historical analysis, however, suggests that it may be useful to reconsider the relationship of AN and BN to the [...] on the effect of Western esthetics rather than the sociology of health care institutions, and has important implications for policy and publicity about eating disorders, the question of how culture and [...] the broader class of somatoform disorders. Also, by conferring legitimacy on this...
New 2‑aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities (Publications)
formation of guanidines with suitable amines. The prepared compounds differ from each other by the substitutions of their amino group and of their phenyl ring. The 2-aminopyrimidines were tested by use of microplate [...] cells (rat skeletal myoblasts). Some of the compounds exhibited quite good antitrypanosomal activity, and others showed excellent antiplasmodial activity. The influence of the structural modifications on these [...] their in vitro activities against a causative organism of...
Reasons for false-positive lipoarabinomannan ELISA results in a Tanzanian population [Short communication] (Publications)
Lipoarabinomannan (LAM), a cell wall component of mycobacteria, can be detected in the urine of tuberculosis (TB) patients. Advantages of this diagnostic include the ease of sample collection and test methods. However [...] false-positive results of the enzyme-linked immunosorbent assay (ELISA) for LAM; however, contamination with blood, as well as bacterial or fungal organisms, had no influence. The collection of urine for the detection [...] need assessment under real working conditions. Our...