Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species (Publications)
Experience of its use in the treatment of rheumatoid arthritis indicates that it could be safe and efficacious for treating malaria. We sought to establish a murine malaria model to study the mechanism of action [...] receptor/transport to gain access to cells, their lack of efficacy against the four tested murine malaria species may be the result of inefficiency of drug transport [...] action and resistance of MTX and its analogue aminopterin (AMP). We used Plasmodium berghei, Plasmodium yoelii...
Reasons for false-positive lipoarabinomannan ELISA results in a Tanzanian population [Short communication] (Publications)
Lipoarabinomannan (LAM), a cell wall component of mycobacteria, can be detected in the urine of tuberculosis (TB) patients. Advantages of this diagnostic include the ease of sample collection and test methods. However [...] false-positive results of the enzyme-linked immunosorbent assay (ELISA) for LAM; however, contamination with blood, as well as bacterial or fungal organisms, had no influence. The collection of urine for the detection [...] need assessment under real working conditions. Our...
Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species (Publications)
Experience of its use in the treatment of rheumatoid arthritis indicates that it could be safe and efficacious for treating malaria. We sought to establish a murine malaria model to study the mechanism of action [...] receptor/transport to gain access to cells, their lack of efficacy against the four tested murine malaria species may be the result of inefficiency of drug transport [...] action and resistance of MTX and its analogue aminopterin (AMP). We used Plasmodium berghei, Plasmodium yoelii...
Early age at menarche, lung function and adult asthma (Publications)
RATIONALE: Hormonal and metabolic status appears to influence lung health in women, and there are findings suggesting that early menarche may be related to asthma, cardiovascular disease, diabetes and [...] and breast cancer. OBJECTIVES: This study investigates whether age of menarche was related to adult lung function and asthma. MEASUREMENTS: Among participants in the European Community Respiratory Health [...] questionnaire concerning women's health (1998-2002). 2873 had lung function...
Early age at menarche, lung function and adult asthma (Publications)
RATIONALE: Hormonal and metabolic status appears to influence lung health in women, and there are findings suggesting that early menarche may be related to asthma, cardiovascular disease, diabetes and [...] and breast cancer. OBJECTIVES: This study investigates whether age of menarche was related to adult lung function and asthma. MEASUREMENTS: Among participants in the European Community Respiratory Health [...] questionnaire concerning women's health (1998-2002). 2873 had lung function...
Informed choices for attaining the Millennium Development Goals: towards an international cooperative agenda for health-systems research (Publications)
Health systems constraints are impeding the implementation of major global initiatives for health and the attainment of the Millennium Development Goals (MDGs). Research could contribute to overcoming [...] financial and human resources, organisation and delivery of health services, governance, stewardship, knowledge management, and global influences. These topics should be viewed as tentative suggestions [...] is part of a wide-ranging consultation and comment is invited. The potential agenda...
Informed choices for attaining the Millennium Development Goals: towards an international cooperative agenda for health-systems research (Publications)
Health systems constraints are impeding the implementation of major global initiatives for health and the attainment of the Millennium Development Goals (MDGs). Research could contribute to overcoming [...] financial and human resources, organisation and delivery of health services, governance, stewardship, knowledge management, and global influences. These topics should be viewed as tentative suggestions [...] is part of a wide-ranging consultation and comment is invited. The potential agenda...
Infectious Diseases | Swiss TPH (Page)
https://www.swisstph.ch/de/topics/infectious-diseases
also socio-ecological influences to improve the health situation of affected people. Specialists at Swiss TPH pursue numerous projects to gain a deeper insight in the complexity of diseases such as sleeping [...] Infectious Diseases of Poverty Helminths HIV/AIDS Human African Tryponosomiasis (HAT) Malaria Neglected Tropical Diseases (NTDs) Tuberculosis Swiss TPH has a longstanding experience in research into p [...] develop new drugs, therapies and vaccines. Experts at Swiss TPH contribute to...
Measuring and validating physical activity and sedentary behavior comparing a parental questionnaire to accelerometer data and diaries (Publications)
markedly attenuated these associations, suggesting concomitant influences of biological and behavioral processes linked to age. The comparisons of general time indications in the questionnaire with 24h-diary [...] compared 189 parental responses to a questionnaire surveying physical activity and sedentary behavior of children aged 6-14 years, to accelerometer outputs and time activity diaries for the same group. Responses
Measuring and validating physical activity and sedentary behavior comparing a parental questionnaire to accelerometer data and diaries (Publications)
markedly attenuated these associations, suggesting concomitant influences of biological and behavioral processes linked to age. The comparisons of general time indications in the questionnaire with 24h-diary [...] compared 189 parental responses to a questionnaire surveying physical activity and sedentary behavior of children aged 6-14 years, to accelerometer outputs and time activity diaries for the same group. Responses