The influence of genotype on the natural history of types 1 - 3 spinal muscular atrophy (Publications)
severity of spinal muscular atrophy (SMA) is inversely correlated with the number of survival of motor neuron 2 (SMN2) copies an individual has. This observational, retrospective analysis of natural history [...] ventilation, respiratory support, feeding support, scoliosis surgery, and achievement and loss of motor milestones. Of 134 individuals; 33 had two SMN2 copies and 101 had 3 or more copies. Survival was linked [...] scoliosis, as well as loss of motor milestones. SMA disease-related...
Diagnosis of soil-transmitted helminths using the Kato-Katz technique: what is the influence of stirring, storage time and storage temperature on... (Publications)
egg counts of A. lumbricoides and T. trichiura remained stable over time regardless of storage temperature of whole stool samples. Finally, we found a significant reduction of the variation of hookworm and [...] study aimed to study the effect of storage time, storage temperature and stirring of stool samples on fecal egg counts (FECs). METHODOLOGY/PRINCIPAL FINDINGS: In the framework of a clinical trial on Pemba Island [...] dropped close to zero, irrespective of the storage condition. Whole...
The influence of malaria control interventions and climate variability on changes in the geographical distribution of parasite prevalence in Kenya... (Publications)
predictors of parasitaemia risk by age groups (6-59 months and 5-14 years). Parasitaemia risk and the number of infected children were predicted over a 1 × 1 km(2) grid. The probability of the decline [...] BACKGROUND: The burden of malaria in Kenya was showing a declining trend, but appears to have reached a plateau in recent years. This study estimated changes in the geographical distribution of malaria parasite [...] parasite risk in the country between the years 2015 and 2020, and quantified...
The influence of roads on the fine-scale population genetic structure of the dengue vector <em>Aedes aegypti</em> (Linnaeus) (Publications)
roads that can act as a barrier. Roads can influence the population genetic structure of Ae. aegypti. We investigated the genetic structure and gene flow of Ae. aegypti as influenced by a primary road [...] barrier effect of the road. A total of 359 adults and 17 larvae Ae. aegypti were collected from June to September 2017 in 13 sites across EB. North (N1-N8) and South (S1-S5) comprised of 211 and 165 individuals
The influence of jittering DHS cluster locations on geostatistical model-based estimates of malaria risk in Cameroon (Publications)
(displacement) of the geographical coordinates of the clusters, shifting their original locations within a radius of 10 km. Our study assessed the influence of jittering on the estimates of the geographical [...] potential confounding effects of socio-economic factors. Bayesian kriging based on the selected models was used to estimate the geographical distribution of malaria risk. The influence of jittering was analysed [...] were able to capture the main spatial patterns of the disease risk,...
The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant <em>Plasmodium falciparum</em> (Publications)
y quantify which of these factors drive establishment and spread of drug resistance. Drug resistance was more likely to evolve in low transmission settings due to the lower levels of (i) immunity and (ii) [...] n between genotypes. Spread of parasites resistant to artemisinin partner drugs depended on the period of low drug concentration (known as the selection window). Spread of partial artemisinin resistance [...] The effectiveness of artemisinin-based combination therapies (ACTs) to treat...
Influence of testing modality on bioefficacy for the evaluation of Interceptor® G2 mosquito nets to combat malaria mosquitoes in Tanzania (Publications)
impact of bioassay modality, mosquito exposures of the alphacypermethrin ITN Interceptor((R)) and dual adulticide Interceptor((R)) G2 were investigated. METHODS: This study evaluated the performance of In [...] )) G2 compared to Interceptor((R)) against local strains of mosquitoes in Tanzania. Unwashed and 20x times washed nets were tested. Efficacy of ITNs was measured by four bioassay types: (1) World Health [...] resistant strains, superiority of Interceptor((R)) G2 over Interceptor((R)) was...
