Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies (Publications)
luteinizing hormone levels were assessed in a subsample. RESULTS: A quarter of the women were postmenopausal by age 50.8 years. Median age of natural menopause was 54 years. Hormone levels were within expected [...] Surgically induced menopause was highly prevalent (22%-47%), associated with earlier timing of menopause. Determinants of earlier menopause were current smoking (hazard ratio [HR], 1.59; 95% CI, 1.27-1.98), body [...] use yielded heterogeneous effects on timing of menopause. Later...
N-acetyltransferase 2 phenotype but not NAT1*10 genotype affects aminobiphenyl-hemoglobin adduct levels (Publications)
biomarkers of the internal dose of ABP to the bladder. We have also shown that NAT1 genotype (NAT1*10 allele) is associated with increased DNA adduct levels in urothelial tissue and higher risk of bladder [...] etiology in smokers. N-Acetylation of ABPs in the liver, predominantly by the N-acetyltransferase 2 (NAT2) isozyme, represents a detoxification pathway, whereas O-acetylation of N-hydroxy-ABPs in the bladder [...] smokers. It is not known whether NAT1*10 genotype influences ABP-hemoglobin...
Association between allergic sensitization and intestinal parasite infection in schoolchildren in Gqeberha, South Africa (Publications)
Inconsistent data exist regarding the influence of parasitic infection on the prevalence of allergic sensitization and disorders. OBJECTIVE: To investigate the impact of geohelminth and protozoan infections [...] when adjusted for false discovery. Geohelminth infection and intensity of geohelminth infection were both associated with reduced risk of polysensitization (OR 0.41, 95%CI 0.21-0.86), and this association [...] infections on sensitization patterns and allergic symptoms of children...
Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies (Publications)
luteinizing hormone levels were assessed in a subsample. RESULTS: A quarter of the women were postmenopausal by age 50.8 years. Median age of natural menopause was 54 years. Hormone levels were within expected [...] Surgically induced menopause was highly prevalent (22%-47%), associated with earlier timing of menopause. Determinants of earlier menopause were current smoking (hazard ratio [HR], 1.59; 95% CI, 1.27-1.98), body [...] use yielded heterogeneous effects on timing of menopause. Later...
N-acetyltransferase 2 phenotype but not NAT1*10 genotype affects aminobiphenyl-hemoglobin adduct levels (Publications)
biomarkers of the internal dose of ABP to the bladder. We have also shown that NAT1 genotype (NAT1*10 allele) is associated with increased DNA adduct levels in urothelial tissue and higher risk of bladder [...] etiology in smokers. N-Acetylation of ABPs in the liver, predominantly by the N-acetyltransferase 2 (NAT2) isozyme, represents a detoxification pathway, whereas O-acetylation of N-hydroxy-ABPs in the bladder [...] smokers. It is not known whether NAT1*10 genotype influences ABP-hemoglobin...
Association between allergic sensitization and intestinal parasite infection in schoolchildren in Gqeberha, South Africa (Publications)
Inconsistent data exist regarding the influence of parasitic infection on the prevalence of allergic sensitization and disorders. OBJECTIVE: To investigate the impact of geohelminth and protozoan infections [...] when adjusted for false discovery. Geohelminth infection and intensity of geohelminth infection were both associated with reduced risk of polysensitization (OR 0.41, 95%CI 0.21-0.86), and this association [...] infections on sensitization patterns and allergic symptoms of children...
Two new rapid SNP-typing methods for classifying <em>Mycobacterium tuberculosis</em> complex into the main phylogenetic lineages (Publications)
increasing evidence that strain variation in Mycobacterium tuberculosis complex (MTBC) might influence the outcome of tuberculosis infection and disease. To assess genotype-phenotype associations, phylogenetically [...] exhibit very low degrees of homoplasy. In this study, we developed two complementary SNP-based genotyping methods to classify strains into the six main human-associated lineages of MTBC, the "Beijing" sublineage [...] sensitivity in allele-calling was 98.6% and 98.8% for MOL-PCR...
Two new rapid SNP-typing methods for classifying <em>Mycobacterium tuberculosis</em> complex into the main phylogenetic lineages (Publications)
increasing evidence that strain variation in Mycobacterium tuberculosis complex (MTBC) might influence the outcome of tuberculosis infection and disease. To assess genotype-phenotype associations, phylogenetically [...] exhibit very low degrees of homoplasy. In this study, we developed two complementary SNP-based genotyping methods to classify strains into the six main human-associated lineages of MTBC, the "Beijing" sublineage [...] sensitivity in allele-calling was 98.6% and 98.8% for MOL-PCR...
Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome (Publications)
olonged symptoms after SARS-CoV-2 infection are well documented. However, which factors influence development of long-term symptoms, how symptoms vary across ethnic groups, and whether long-term symptoms [...] COVID-19 infections. In total, 40% of participants reported at least 1 symptom associated with COVID-19 six months after diagnosis. Median time from diagnosis to first resolution of all symptoms was 44 days; median [...] all disease severities had a similar risk of developing post-COVID-19...
Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome (Publications)
olonged symptoms after SARS-CoV-2 infection are well documented. However, which factors influence development of long-term symptoms, how symptoms vary across ethnic groups, and whether long-term symptoms [...] COVID-19 infections. In total, 40% of participants reported at least 1 symptom associated with COVID-19 six months after diagnosis. Median time from diagnosis to first resolution of all symptoms was 44 days; median [...] all disease severities had a similar risk of developing post-COVID-19...