Immunohistochemistry: a method to analyze<em> M. ulcerans </em>infected skin tissue (Publications)
Immunohistochemistry (IHC) is a combination of immunological, biochemical, and pathological methods to visualize the presence and distribution of specific epitopes in tissue sections. Selected antigen
Competitive ELISA for the detection and quantification of<em> Mycobacterium ulcerans </em>mycolactone (Publications)
Lipids and other hydrophobic analytes are difficult to quantify by routine immunoassays due to the need to use aqueous buffers. Here, we describe an ELISA protocol suitable for the detection of mycola
Overview: development of drugs against<em> Mycobacterium ulcerans</em> (Publications)
For many years, wide margin surgical excision of Buruli ulcer lesions has been the main approach for the treatment of Mycobacterium ulcerans disease. The WHO now recommends an eight-week course of ora
Overview: mycolactone, the macrolide toxin of <em>Mycobacterium ulcerans</em> (Publications)
The acquisition by a Mycobacterium marinum-like progenitor of a plasmid encoding enzymes for the biosynthesis of the highly potent macrolide toxin mycolactone has set off the evolution of M. ulcerans
Overview: <em>Mycobacterium ulcerans </em>disease (Buruli ulcer) (Publications)
Enhanced international research efforts since the establishment of the Global BU Initiative in 1998 by the WHO have helped to advance our understanding of the epidemiology, and pathogenesis of Mycobac
Clinical diversity and treatment results in tegumentary leishmaniasis: a European clinical report in 459 patients (Publications)
BACKGROUND: Cutaneous leishmaniasis (CL) is frequent in travellers and can involve oro-nasal mucosae. Clinical presentation impacts therapeutic management. METHODOLOGY: Demographic and clinical data f
Chronic wounds in Sierra Leone: searching for Buruli ulcer, a NTD caused b<em>y Mycobacterium ulcerans</em>, at Masanga Hospital (Publications)
BACKGROUND: Chronic wounds pose a significant healthcare burden in low- and middle-income countries. Buruli ulcer (BU), caused by Mycobacterium ulcerans infection, causes wounds with high morbidity an
Leprosy in wild chimpanzees (Publications)
Humans are considered as the main host for Mycobacterium leprae(1), the aetiological agent of leprosy, but spillover has occurred to other mammals that are now maintenance hosts, such as nine-banded a
Challenges and experiences in linking community level reported out-of-pocket health expenditures to health provider recorded health expenditures:... (Publications)
Out of pocket health payment (OOPs) has been identified by the System of Health Accounts (SHA) as the largest source of health care financing in most low and middle-income countries. This means that m