On the origin of <em>Mycobacterium ulcerans</em>, the causative agent of Buruli ulcer (Publications)
ABSTRACT: BACKGROUND: Mycobacterium ulcerans is an unusual bacterial pathogen with elusive origins. While closelyrelated to the aquatic dwelling M. marinum, M. ulcerans has evolved the ability to prod
Implementing new health interventions in developing countries: why do we lose a decade or more? (Publications)
BACKGROUND: It is unclear how long it takes for health interventions to transition from research and development (R&D) to being used against diseases prevalent in resource-poor countries. We undertook
Do existing research summaries on health systems match immunisation managers' needs in middle- and low-income countries? Analysis of GAVI health... (Publications)
ABSTRACT: BACKGROUND: The GAVI Alliance was created in 2000 to increase access to vaccines. More recently, GAVI has supported evidence-based health systems strengthening to overcome barriers to vaccin
Paediatric referrals in rural Tanzania: the Kilombero District Study - a case series (Publications)
BACKGROUND: Referral is a critical part of appropriate primary care and of the Integrated Management of Childhood Illness (IMCI) strategy. We set out to study referrals from the aspect both of primary
Artesunate-mefloquine combination therapy in acute <em>Plasmodium falciparum</em> malaria in young children: a field study regarding neurological and... (Publications)
BACKGROUND: Mefloquine-artesunate combination therapy for uncomplicated falciparum malaria is one of the treatments used in African children. Data concerning neurological safety in adults and children
A tool box for operational mosquito larval control: preliminary results and early lessons from the Urban Malaria Control Programme in Dar es Salaam,... (Publications)
BACKGROUND: As the population of Africa rapidly urbanizes, large populations could be protected from malaria by controlling aquatic stages of mosquitoes if cost-effective and scalable implementation s
Global burden of human brucellosis: a systematic review of disease frequency (Publications)
BACKGROUND: This report presents a systematic review of scientific literature published between 1990-2010 relating to the frequency of human brucellosis, commissioned by WHO. The objectives were to id
Malaria chemoprophylaxis recommendations for immigrants to Europe, visiting relatives and friends: a Delphi method study (Publications)
BACKGROUND: Numbers of travellers visiting friends and relatives (VFRs) from Europe to malaria endemic countries are increasing and include long-term and second generation immigrants, who represent th
A major role for the <em>Plasmodium falciparum</em> ApiAP2 protein PfSIP2 in chromosome end biology (Publications)
The heterochromatic environment and physical clustering of chromosome ends at the nuclear periphery provide a functional and structural framework for antigenic variation and evolution of subtelomeric