Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity (Publications)
African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma bru
Metabolic profiling framework for discovery of candidate diagnostic markers of malaria (Publications)
Despite immense efforts to combat malaria in tropical and sub-tropical regions, the potency of this vector-borne disease and its status as a major driver of morbidity and mortality remain undisputed.
Association of long-term exposure to traffic-related air pollution with blood pressure and hypertension in an adult population-based cohort in Spain... (Publications)
BACKGROUND: Long-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension; however evidence is limited and this association may be confounded by traffic
Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical<em> Trypanosoma</em> <em>brucei... (Publications)
Aquaglyceroporin-2 is a known determinant of melarsoprol-pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2-AQP3 tandem locus was describ
Pregnancy-related mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites (Publications)
BACKGROUND: Women continue to die in unacceptably large numbers around the world as a result of pregnancy, particularly in sub-Saharan Africa and Asia. Part of the problem is a lack of accurate, popul
Annoyance caused by noise and air pollution during pregnancy: associated factors and correlation with outdoor NO2 and benzene estimations (Publications)
This study aimed to describe the degree of annoyance among pregnant women in a Spanish cohort and to examine associations with proximity to traffic, NO2 and benzene exposure. We included 2457 particip
High prevalence of <em>Ancylostoma ceylanicum</em> hookworm infections in humans, Cambodia, 2012 (Publications)
Ancylostoma ceylanicum, a hookworm of canids and felids in Asia, is becoming the second most common hookworm infecting humans. In 2012, we investigated the prevalence and infection dynamics of and ris
Space and time clustering of mortality in rural South Africa (Agincourt HDSS), 1992-2007 (Publications)
BACKGROUND: Detailed information regarding the spatial and/or spatial-temporal distribution of mortality is required for the efficient implementation and targeting of public health interventions. OBJE
Antiprotozoal activities of organic extracts from French marine seaweeds (Publications)
Marine macrophytes contain a variety of biologically active compounds, some reported to have antiprotozoal activity in vitro. As a part of a screening program to search for new natural antiprotozoals,
Risk stratification for 1-year mortality in acute heart failure: classification and regression tree analysis (Publications)
BACKGROUND: Simple tools for risk stratification of patients with acute heart failure (AHF) are an unmet clinical need, particularly regarding long-term mortality. METHODS: We prospectively enrolled 6
