Extrapulmonary tuberculosis in HIV-infected patients in rural Tanzania: the prospective Kilombero and Ulanga antiretroviral cohort (Publications)
BACKGROUND: In sub-Saharan Africa, diagnosis and management of extrapulmonary tuberculosis (EPTB) in people living with HIV (PLHIV) remains a major challenge. This study aimed to characterize the epid
Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in <em>Trypanosoma brucei</em> (Publications)
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. Due to its size and sixfold negative charge, uptake is mediated throug
Applied mathematical modelling to inform national malaria policies, strategies and operations in Tanzania (Publications)
BACKGROUND: More than ever, it is crucial to make the best use of existing country data, and analytical tools for developing malaria control strategies as the heterogeneity in malaria risk within coun
Effects of transportation noise and particulate matter on the cardiovascular system: what is the new evidence? (Publications)
SUMMARY: Several decades of research provides compelling evidence that exposure to air pollution causes various diseases. Time series studies in Europe and the USA examined the short term effects on m
Prospective assessment of loss to follow-up: incidence and associated factors in a cohort of HIV-positive adults in rural Tanzania (Publications)
INTRODUCTION: Lifelong antiretroviral therapy (ART) improves health outcomes for HIV-positive individuals, but is jeopardized by irregular clinic attendance and hence poor adherence. Loss to follow-up
Use of insecticides in agriculture and the prevention of vector-borne diseases: population knowledge, attitudes, practices and beliefs in Elibou,... (Publications)
People's knowledge, attitudes, practices and beliefs (KAPB) pertaining to malaria are generally well described. However, little is known about population knowledge and awareness of insecticide resista
The immunology of other mycobacteria:<em> M. ulcerans, M. leprae</em> (Publications)
Mycobacterial pathogens can be categorized into three broad groups: Mycobacterium tuberculosis complex causing tuberculosis, M. leprae and M. lepromatosis causing leprosy, and atypical mycobacteria, o
The role of HIV asymptomatic status when starting ART on adherence and treatment outcomes and implications for test and treat: the Swiss HIV Cohort... (Publications)
BACKGROUND: Since the advent of universal test and treat policies, a higher share of people living with HIV (PLHIV) initiating ART are asymptomatic with a preserved immune system. We explored the pote
Epitope mapping and fine specificity of human T and B cell responses for novel candidate blood-stage malaria vaccine P27A (Publications)
P27A is a novel synthetic malaria vaccine candidate derived from the blood stage Plasmodium falciparum protein Trophozoite Exported Protein 1 (TEX1/PFF0165c). In phase 1a/1b clinical trials in malaria