High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds (Publications)
Rapidly spreading antibiotic resistance and the low discovery rate of new antimicrobial compounds demand more effective strategies for early drug discovery. One bottleneck in the drug discovery pipeli
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic... (Publications)
African trypanosomiasis is a neglected parasitic disease that is still of great public health relevance, and a severe impediment to agriculture in endemic areas. The pathogens possess certain unique m
Ecology and evolution of <em>Mycobacterium tuberculosis</em> (Publications)
Tuberculosis (TB) is the number one cause of human death due to an infectious disease. The causative agents of TB are a group of closely related bacteria known as the Mycobacterium tuberculosis comple
How elimination of lymphatic filariasis as a public health problem in the Kingdom of Cambodia was achieved (Publications)
BACKGROUND: Endemicity of lymphatic filariasis (LF) in Cambodia was proven in 1956 when microfilariae were detected in mosquitos in the Kratie province. In 2001, an extensive study confirmed the prese
Insufficient fruit and vegetable intake in a low- and middle-income setting: a population-based survey in semi-urban Tanzania (Publications)
A daily intake of 5 portions of fruit and vegetables (FV) is recommended for protection against non-communicable diseases (NCDs). Inadequate FV intake is a global problem but resource-poor countries l
Impact of diagnostic test Xpert MTB/RIF® on health outcomes for tuberculosis (Publications)
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: to assess the impact of Xpert MTB/RIF on important patient outcomes for people with tuberculosis.
On a mission to block transmission (Publications)
The controlled infection of volunteers with Plasmodium falciparum parasites could provide a platform to evaluate new drugs and vaccines aimed at blocking malaria transmission.