Heteronuclear 19F-1H statistical total correlation spectroscopy as a tool in drug metabolism: study of flucloxacillin biotransformation (Publications)
We present a novel application of the heteronuclear statistical total correlation spectroscopy (HET-STOCSY) approach utilizing statistical correlation between one-dimensional 19F/1H NMR spectroscopic
Interactions of mefloquine with praziquantel in the <em>Schistosoma mansoni</em> mouse model and <em>in vitro</em> (Publications)
Objectives Mefloquine has interesting antischistosomal properties, hence it might be an attractive partner drug for combination treatment with praziquantel. The aim of this study was to evaluate activ
Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes (Publications)
Over 40 million people are infected with food-borne trematodes and 750 million are at risk of food-borne trematodiasis, and yet this tropical disease is neglected. The current arsenal for the treatmen
Trematocidal activity of praziquantel and artemisinin derivatives:<em> in vitro</em> and <em>in vivo</em> investigations with adult <em>Echinostoma... (Publications)
We examined the effects of praziquantel and the artemisinins on adult Echinostoma caproni. In vitro, both praziquantel and the artemisinins exhibited exposure-response relationships. In vivo, worm bur