Diagnostic genotyping of old and new world <em>Leishmania</em> species by PCR-RFLP (Publications)
We have designed a new genotyping scheme for molecular diagnosis of the different Leishmania species pathogenic to humans. This scheme is based on PCR amplified sequences from the gene for the spliced
Towards empirical description of malaria seasonality in southern Africa: the example of Zimbabwe (Publications)
BACKGROUND: Quantitative description and mapping of malaria seasonality is important for timely spatial targeting of interventions and for modelling malaria risk. There is a need for seasonality model
<em>Trichinella spiralis</em>: immunization of pigs with newborn larval antigens (Publications)
The potential of crude Trichinella spiralis newborn larval antigens for pig immunization was investigated. A preparation of whole newborn larvae killed by freezing and thawing, and combined with Freun
Combination of single nucleotide polymorphism and variable-number tandem repeats for genotyping a homogenous population of <em>Mycobacterium... (Publications)
The standard 15- and 24-locus variable-number tandem repeat (VNTR) genotyping methods have demonstrated adequate discriminatory power and a small homoplasy effect for tracing tuberculosis (TB) transmi
Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models (Publications)
There are currently only four clinical drugs available for treating human African trypanosomiasis (HAT), three of which were developed over 60years ago. Despite years of effort, there has been relativ
Pouched rats' detection of tuberculosis in human sputum: comparison to culturing and polymerase chain reaction (Publications)
Setting. Tanzania. Objective. To compare microscopy as conducted in direct observation of treatment, short course centers to pouched rats as detectors of Mycobacterium tuberculosis. Design. Ten pouche
The emergence of angiostrongyliasis in the People's Republic of China: the interplay between invasive snails, climate change and transmission... (Publications)
P> 1. Only few freshwater snail species transmit the rat lungworm Angiostrongylus cantonensis, which is partially explained by the low likelihood of contact between snails and infected rat faeces. The
An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from <em>Eupatorium perfoliatum</em> (Publications)
The CH(2)Cl(2) extract of aerial parts of Eupatorium perfoliatum L. exhibits antiprotozoal activity under in vitro conditions, especially against Plasmodium falciparum (IC(50)=2.7mug/ml). The search f
