Medium-ring keto bislactams with antischistosomal activity (Publications)
We discovered medium-ring keto bislactams as a new antischistosomal chemotype. The ketone functional group and isoindolinone substructure were required for high antischistosomal activity. Aryl substit
Rapid increase in the risk of heat-related mortality (Publications)
Heat-related mortality has been identified as one of the key climate extremes posing a risk to human health. Current research focuses largely on how heat mortality increases with mean global temperatu
Malaria rapid tests, febrile illness management, and child mortality across sub-Saharan African countries (Publications)
IMPORTANCE: A prompt malaria diagnosis is crucial for the management of children with febrile illness in sub-Saharan African countries, where malaria remains a leading cause of mortality among childre
<em>In vitro</em> antischistosomal activity of <em>Bridelia ferruginea, Clausena anisata, Khaya senegalensis, </em>and <em>Vernonia amygdalina</em> (Publications)
BACKGROUND: Schistosomiasis is caused by parasitic flatworms and the disease is endemic to most countries in sub-Saharan Africa including Ghana. The current therapeutic agent for managing this disease
Potential impact of climatic factors on malaria in Rwanda between 2012 and 2021: a time-series analysis (Publications)
BACKGROUND: Malaria remains an important public health problem, particularly in sub-Saharan Africa. In Rwanda, where malaria ranks among the leading causes of mortality and morbidity, disease transmis
Cryptic population structure and insecticide resistance in <em>Anopheles gambiae</em> from the southern Democratic Republic of Congo (Publications)
The Democratic Republic of Congo (DRC) suffers from one of the highest malaria burdens worldwide, but information on its Anopheles vector populations is relatively limited. Preventative malaria contro
Spatio-temporal dynamics of malaria in Rwanda between 2012 and 2022: a demography-specific analysis (Publications)
BACKGROUND: Despite global efforts to reduce and eventually interrupt malaria transmission, the disease remains a pressing public health problem, especially in sub-Saharan Africa. This study presents
3-Benzylmenadiones and their heteroaromatic analogues target the apicoplast of apicomplexa parasites: synthesis and bioimaging studies (Publications)
The apicoplast is an essential organelle for the viability of apicomplexan parasites Plasmodium falciparum or Toxoplasma gondii, which has been proposed as a suitable drug target for the development o
Waiting for surgery after hip fracture: health and/or economic risk? (Publications)
OBJECTIVES: Waiting for surgery is a disconcerting experience. It can have a negative impact on patients' outcomes and length of stay (LOS) as driver for treatment costs. Process-optimisation may be a
