Influence of <em>M. tuberculosis</em> lineage variability within a clinical trial for pulmonary tuberculosis (Publications)
Recent studies suggest that M. tuberculosis lineage and host genetics interact to impact how active tuberculosis presents clinically. We determined the phylogenetic lineages of M. tuberculosis isolate
Comparative genomics of metabolic networks of free-living and parasitic eukaryotes (Publications)
BACKGROUND: Obligate endoparasites often lack particular metabolic pathways as compared to free-living organisms. This phenomenon comprises anabolic as well as catabolic reactions. Presumably, the cor
Molecular characterisation of <em>Mycobacterium bovis</em> isolated from cattle slaughtered at the Bamako abattoir in Mali (Publications)
Background: Mali is one of the most important livestock producers of the Sahel region of Africa. A high frequency of bovine tuberculosis (BTB) has been reported but surveillance and control schemes ar
Guidance for evidence-informed policies about health systems: assessing how much confidence to place in the research evidence (Publications)
In the third paper in a three-part series on health systems guidance, Simon Lewin and colleagues explore the challenge of assessing how much confidence to place in evidence on health systems intervent
Genome-wide identification of molecular mimicry candidates in parasites (Publications)
Among the many strategies employed by parasites for immune evasion and host manipulation, one of the most fascinating is molecular mimicry. With genome sequences available for host and parasite, mimic
Mefloquine - an aminoalcohol with promising antischistosomal properties in mice (Publications)
BACKGROUND: The treatment and control of schistosomiasis, an often neglected tropical disease that exacerbates poverty, depends on a single drug, praziquantel. The large-scale use of praziquantel migh
Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage rhodesiense sleeping sickness (Publications)
OBJECTIVE: Assessment of the safety and efficacy of a 10-day melarsoprol schedule in second stage T.b. rhodesiense patients and the effect of suramin-pretreatment on the incidence of encephalopathic s
Differential patterns of infection and disease with <em>P. falciparum</em> and <em>P. vivax</em> in young Papua New Guinean children (Publications)
BACKGROUND: Where P. vivax and P. falciparum occur in the same population, the peak burden of P. vivax infection and illness is often concentrated in younger age groups. Experiences from malaria thera
