Reverse innovation in global health (Publications)
The term “reverse innovation”, also known as “trickle-up innovation” is being popularized since 2010 with an initial focus on corporate development and economics. In brief, reverse innovation refers t
Structure–activity relationship and<em> in vitro</em> absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies of <em>N</em>-aryl... (Publications)
We have previously reported on the antischistosomal activity of pyrido [1,2-a] benzimidazole (PBI) derivatives. As a follow-up, we designed and prosecuted further structure-activity relationship (SAR)
Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action (Publications)
A drug repositioning approach was leveraged to derivatize astemizole (AST), an antihistamine drug whose antimalarial activity was previously identified in a high-throughput screen. The multistage acti