Determinants of patient delay in diagnosis of pulmonary tuberculosis in Somali pastoralist setting of Ethiopia: a matched case-control study (Publications)
Background: Healthcare-seeking behavior is the basis to ensure early diagnosis and treatment of tuberculosis (TB) in settings where most cases are diagnosed upon self-presentation to health facilities
Guide posts for investment in primary health care and projected resource needs in 67 low-income and middle-income countries: a modelling study (Publications)
BACKGROUND: Primary health care (PHC) is a driving force for advancing towards universal health coverage (UHC). PHC-oriented health systems bring enormous benefits but require substantial financial in
Multiplicity of asymptomatic <em>Plasmodium falciparum </em>infections and risk of clinical malaria: a systematic review and pooled analysis of... (Publications)
BACKGROUND: The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity, i.e. the number of co-infecting clones, in
Physiologically based pharmacokinetic modelling to identify pharmacokinetic parameters driving drug exposure changes in the elderly (Publications)
BACKGROUND: Medication use is highly prevalent with advanced age, but clinical studies are rarely conducted in the elderly, leading to limited knowledge regarding age-related pharmacokinetic changes.
Pulmonary cryptococcosis: report of the first confirmed autochthonous case in Nepal (Publications)
We report a case of cryptococcal pneumonia in a 53 years old female Nepali patient with uncontrolled diabetes mellitus type 2 who empirically received multiple broad-spectrum antibiotics and standard
Characterization of <em>Salmonella</em> enterica from invasive bloodstream infections and water sources in rural Ghana (Publications)
BACKGROUND: Non-typhoidal Salmonella (NTS) cause the majority of bloodstream infections in Ghana, however the mode of transmission and source of invasive NTS in Africa are poorly understood. This stud
Recovery of an environmental Chlamydia strain from activated sludge by co-cultivation with <em>Acanthamoeba</em> sp. (Publications)
Chlamydiae are a unique group of obligate intracellular bacteria comprising important pathogens of vertebrates as well as symbionts of free-living amoebae. Although there is ample molecular evidence f
Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? (Publications)
Brucellosis, Q fever and melioidosis are zoonoses, which can lead to pyrexia. These diseases are often under-ascertained and underreported because of their unspecific clinical signs and symptoms, insu
